ULK3 - unc-51 like kinase 3 Gene

Homo sapiens

Gene ID: 25989 | Gene type: protein coding

About ULK3

Cytogenetic location: 15q24.1 Genomic coordinates (GRCh38): 15:74,836,118-74,843,156 (from NCBI)

This gene has 24 transcripts (splice variants), 204 orthologues and 2 paralogues. Ubiquitous expression in skin (RPKM 31.2), small intestine (RPKM 22.9) and 25 other tissues.

Summary

Enables protein serine/threonine kinase activity. Involved in several processes, including fibroblast activation; protein autophosphorylation; and regulation of smoothened signaling pathway. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ULK3 Products(4)

mRNA	Protein	Name
NM_001099436.4	NP_001092906.3	serine/threonine-protein kinase ULK3 isoform a
NM_001284364.3	NP_001271293.2	serine/threonine-protein kinase ULK3 isoform b
NM_001284365.3	NP_001271294.1	serine/threonine-protein kinase ULK3 isoform c
NM_001411082.1	NP_001398011.1	serine/threonine-protein kinase ULK3 isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20643644	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	19878745	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fibroblast activation	IMP IMP: Inferred from mutant phenotype	28877478	GOA
involved in negative regulation of smoothened signaling pathway	IDA IDA: Inferred from direct assay	20643644	GOA
involved in positive regulation of smoothened signaling pathway	IDA IDA: Inferred from direct assay	19878745	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	19878745	GOA
involved in smoothened signaling pathway	IDA IDA: Inferred from direct assay	31279575	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	19878745	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ULK3 Protein Structure

Pkinase

MIT

0
100
200
300
400
472 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase ULK3

ULK3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ULK3	Q6PHR2	CDC37	Homo sapiens	Q16543	Pull Down	32707033
Intra	ULK3	Q6PHR2	FKBP5	Homo sapiens	Q13451	Pull Down	32707033
Intra	ULK3	Q6PHR2	FKBP5	Homo sapiens	Q13451	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Non-Syndromic X-Linked Intellectual Disability 97

Mrx65	Mrx97
Mrxz	X-Linked Mental Retardation 65
X-Linked Mental Retardation 97

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15457	ULK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ULK3	VGNC	VGNC:48130
Bos taurus	ULK3	VGNC	VGNC:36660
Felis catus	ULK3	VGNC	VGNC:66816
Macaca mulatta	ULK3	VGNC	VGNC:99339
Mus musculus	ULK3	MGD	MGI:1918992
Rattus norvegicus	ULK3	RGD	RGD:1587417
Others	ULK3	NCBI

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