2. Gene
  3. TENM4 - teneurin transmembrane protein 4 Gene

TENM4 - teneurin transmembrane protein 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as Doc4; ETM5; ODZ4; TEN4; TNM4; ten-4; Ten-M4

Gene ID: 26011 | Gene type: protein coding

About TENM4

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:78,652,829-79,441,030 (from NCBI)

This gene has 11 transcripts (splice variants), 204 orthologues, 4 paralogues and is associated with 2 phenotypes. Biased expression in ovary (RPKM 7.7), thyroid (RPKM 3.2) and 8 other tissues.

Summary

The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]

TENM4 Products(1)

mRNA Protein Name
NM_001098816.3 NP_001092286.2 teneurin-4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in central nervous system myelin formation IMP
IMP: Inferred from mutant phenotype
26188006 GOA
involved in neuron development IMP
IMP: Inferred from mutant phenotype
26188006 GOA
involved in regulation of myelination IMP
IMP: Inferred from mutant phenotype
26188006 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
26188006 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TENM4 Protein Structure

Ten_N

Ten_N: Teneurin Intracellular Region (10 - 167)

Ten_N

Ten_N: Teneurin Intracellular Region (165 - 340)

EGF_2

EGF_2: EGF-like domain (729 - 755)

hEGF

hEGF: Human growth factor-like EGF (774 - 786)

RHS_repeat

RHS_repeat: RHS Repeat (2271 - 2302)

Tox-GHH

Tox-GHH: GHH signature containing HNH/Endo VII superfamily nuclease toxin (2684 - 2762)

  • 0
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  • 2500
  • 2769 a.a.
Protein Preferred Names Protein Names

teneurin-4

downstream of CHOP 4

TENM4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra TENM4 Q6N022 ZNF696 Homo sapiens Q9H7X3
Validated Y2H
32296183
Intra TENM4 Q6N022 SHFL Homo sapiens Q9NUL5-4
Validated Y2H
32296183
Intra TENM4 Q6N022 DOCK2 Homo sapiens Q92608
Validated Y2H
32296183
Intra TENM4 Q6N022 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra TENM4 Q6N022 LCE3D Homo sapiens Q9BYE3
Validated Y2H
32296183
Intra TENM4 Q6N022 PLSCR4 Homo sapiens Q9NRQ2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Tremor, Hereditary Essential, 5

ETM5

Essential Tremor 5

Essential Tremor, Hereditary, 5

Hereditary Essential Tremor 5

Tremor, Hereditary Essential 5

Tremor, Essential Hereditary, Type 5
Tremor

Medicament-Induced Tremor

Medication-Induced Postural Tremor
Essential Tremor

Benign Essential Tremor

Familial Tremor

Hereditary Essential Tremor

Essential Hereditary Tremor

Shaky Hand Syndrome

Benign Essential Tremor Syndrome

Tremor Hereditary Essential

Essential Tremor, Susceptibility To

Tremor, Hereditary Essential
Cleft Palate, Proliferative Retinopathy, And Developmental Delay

CPPRDD
Tremor, Hereditary Essential, 1

ETM1

Fet1

Essential Tremor 1

Tremor, Familial Essential, 1

Essential Tremor, Hereditary, 1

Hereditary Essential Tremor 1

Tremor Hereditary Essential, 1

Tremor Familial Essential, 1

Tremor, Hereditary Essential 1

Tremor, Essential Hereditary, Type 1
Bardet-Biedl Syndrome 2

BBS2

Bardet-Biedl Syndrome

Bardet-Biedl Syndrome, Type 2

Bbs
Tremor, Hereditary Essential, 4

ETM4

Essential Tremor 4

Essential Tremor, Hereditary, 4

Hereditary Essential Tremor 4

Tremor, Hereditary Essential 4

Tremor, Hereditary Essential, Type 4
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14365 TENM4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TENM4 VGNC VGNC:66072
Macaca mulatta TENM4 VGNC VGNC:107649
Canis familiaris TENM4 VGNC VGNC:54999
Mus musculus TENM4 MGD MGI:2447063
Rattus norvegicus TENM4 RGD RGD:1304658
Bos taurus TENM4 VGNC VGNC:35744