2. Gene
  3. PLSCR4 - phospholipid scramblase 4 Gene

PLSCR4 - phospholipid scramblase 4 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TRA1

Gene ID: 57088 | Gene type: protein coding

About PLSCR4

Cytogenetic location: 3q24 Genomic coordinates (GRCh38): 3:146,192,335-146,251,105 (from NCBI)

This gene has 11 transcripts (splice variants), 408 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 22.0), gall bladder (RPKM 21.1) and 24 other tissues.

Summary

Enables CD4 receptor binding activity and Enzyme binding activity. Predicted to be involved in plasma membrane phospholipid scrambling. Predicted to act upstream of or within cellular response to lipopolysaccharide. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

PLSCR4 Products(5)

mRNA Protein Name
NM_001128304.2 NP_001121776.1 phospholipid scramblase 4 isoform a
NM_001128305.2 NP_001121777.1 phospholipid scramblase 4 isoform a
NM_001128306.2 NP_001121778.1 phospholipid scramblase 4 isoform b
NM_001177304.2 NP_001170775.1 phospholipid scramblase 4 isoform c
NM_020353.3 NP_065086.2 phospholipid scramblase 4 isoform a
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables CD4 receptor binding IPI
IPI: Inferred from physical interaction
19333378 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
19333378 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
19333378 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLSCR4 Protein Structure

Scramblase

Scramblase: Scramblase (100 - 322)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
Protein Preferred Names Protein Names

phospholipid scramblase 4

Ca(2+)-dependent phospholipid scramblase 4

PLSCR4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
PLSCR4 Q9NRQ2 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 TEKT5 Homo sapiens Q96M29
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 TEKT5 Homo sapiens Q96M29
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 NID2 Homo sapiens Q8IV28
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 NID2 Homo sapiens Q8IV28
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 KRT82 Homo sapiens Q9NSB4
Validated Y2H
32296183
Intra
PLSCR4 Q9NRQ2 KRT82 Homo sapiens Q9NSB4
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRT82 Homo sapiens Q9NSB4
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 CLPP Homo sapiens Q16740
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 CLPP Homo sapiens Q16740
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 KPRP Homo sapiens Q5T749
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 KPRP Homo sapiens Q5T749
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 LCE2B Homo sapiens O14633
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 LCE2B Homo sapiens O14633
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP1-5 Homo sapiens Q9BYS1
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP1-5 Homo sapiens Q9BYS1
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 LCE5A Homo sapiens Q5TCM9
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 LCE5A Homo sapiens Q5TCM9
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 PCSK5 Homo sapiens Q92824-2
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 PCSK5 Homo sapiens Q92824-2
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 LCE1A Homo sapiens Q5T7P2
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 LCE1A Homo sapiens Q5T7P2
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 FCHO1 Homo sapiens A0A0C3SFZ9
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP6-1 Homo sapiens Q3LI64
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP6-1 Homo sapiens Q3LI64
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 CES1 Homo sapiens P23141-3
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 CES1 Homo sapiens P23141-3
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP19-6 Homo sapiens Q3LI70
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP19-6 Homo sapiens Q3LI70
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 SLC15A2 Homo sapiens Q16348
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 SLC15A2 Homo sapiens Q16348
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 RBP3 Homo sapiens P10745
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 RBP3 Homo sapiens P10745
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 ATP23 Homo sapiens Q9Y6H3
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 ATP23 Homo sapiens Q9Y6H3
Validated Y2H
32296183
Intra
PLSCR4 Q9NRQ2 ATP23 Homo sapiens Q9Y6H3
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 OXER1 Homo sapiens Q8TDS5
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 OXER1 Homo sapiens Q8TDS5
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 TENM4 Homo sapiens Q6N022
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 TENM4 Homo sapiens Q6N022
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP21-2 Homo sapiens Q3LI59
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP21-2 Homo sapiens Q3LI59
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 UBC Homo sapiens P0CG48
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 UBC Homo sapiens P0CG48
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 UBA52 Homo sapiens P62987
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 UBA52 Homo sapiens P62987
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 RPS27A Homo sapiens P62979
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 RPS27A Homo sapiens P62979
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 TRIP13 Homo sapiens Q15645
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 TRIP13 Homo sapiens Q15645
Y2H Prey Pooling
32296183
Cross
PLSCR4 Q9NRQ2 Hoxa1 Mus musculus P09022
Y2H
23088713
Intra
PLSCR4 Q9NRQ2 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 UBB Homo sapiens P0CG47
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 UBB Homo sapiens P0CG47
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 CRCT1 Homo sapiens Q9UGL9
Validated Y2H
32296183
Intra
PLSCR4 Q9NRQ2 CRCT1 Homo sapiens Q9UGL9
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 CRCT1 Homo sapiens Q9UGL9
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 CFAP68 Homo sapiens Q9H5F2
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 CFAP68 Homo sapiens Q9H5F2
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 RBPMS Homo sapiens Q93062-3
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 RBPMS Homo sapiens Q93062-3
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 DDIT4L Homo sapiens Q96D03
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 DDIT4L Homo sapiens Q96D03
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 MTUS2 Homo sapiens Q5JR59
Validated Y2H
25416956
Intra
PLSCR4 Q9NRQ2 MTUS2 Homo sapiens Q5JR59
Y2H
21516116
Intra
PLSCR4 Q9NRQ2 RAMAC Homo sapiens Q9BTL3
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 RAMAC Homo sapiens Q9BTL3
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 HDHD3 Homo sapiens Q9BSH5
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 HDHD3 Homo sapiens Q9BSH5
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 INTS11 Homo sapiens Q5TA45
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 INTS11 Homo sapiens Q5TA45
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 TSPAN4 Homo sapiens O14817
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 TSPAN4 Homo sapiens O14817
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 GATA1 Homo sapiens P15976-2
Y2H Array
32296183
Intra
PLSCR4 Q9NRQ2 GATA1 Homo sapiens P15976-2
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Intra
PLSCR4 Q9NRQ2 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
PLSCR4 Q9NRQ2 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Intra
PLSCR4 Q9NRQ2 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
PLSCR4 Q9NRQ2 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Intra
PLSCR4 Q9NRQ2 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Atypical Choroid Plexus Papilloma

Atypical Papilloma Of Choroid Plexus

Atypical Cpp
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10743 PLSCR4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PLSCR4 VGNC VGNC:33053
Mus musculus PLSCR4 MGD MGI:2143267
Canis familiaris PLSCR4 VGNC VGNC:44713
Macaca mulatta PLSCR4 VGNC VGNC:76036
Rattus norvegicus PLSCR4 RGD RGD:1311693