DOCK2 - dedicator of cytokinesis 2 Gene

Homo sapiens

Also known as IMD40

Gene ID: 1794 | Gene type: protein coding

About DOCK2

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:169,637,275-170,083,382 (from NCBI)

This gene has 18 transcripts (splice variants), 235 orthologues, 10 paralogues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 13.3), bone marrow (RPKM 11.2) and 15 other tissues.

Summary

The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin Cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018]

DOCK2 Products(1)

mRNA	Protein	Name
NM_004946.3	NP_004937.1	dedicator of cytokinesis protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables T cell receptor binding	IDA IDA: Inferred from direct assay	12176041	GOA
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	10559471	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12134158	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOCK2 Protein Structure

SH3_2

DOCK-C2

DHR-2

0
300
600
900
1200
1500
1830 a.a.

Protein Preferred Names

Protein Names

dedicator of cytokinesis protein 2

dedicator of cyto-kinesis 2

DOCK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DOCK2	Q92608	KRT40	Homo sapiens	Q6A162	Y2H Array	32296183
Intra	DOCK2	Q92608	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP10-8	Homo sapiens	P60410	Y2H Array	25416956
Intra	DOCK2	Q92608	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	25416956
Intra	DOCK2	Q92608	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	DOCK2	Q92608	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	DOCK2	Q92608	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	DOCK2	Q92608	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP4-2	Homo sapiens	Q9BYR5	Validated Y2H	25416956
Intra	DOCK2	Q92608	KRTAP4-2	Homo sapiens	Q9BYR5	Y2H Array	25416956
Intra	DOCK2	Q92608	KRTAP9-4	Homo sapiens	Q9BYQ2	Y2H Array	25416956
Intra	DOCK2	Q92608	KRTAP9-4	Homo sapiens	Q9BYQ2	Validated Y2H	25416956
Intra	DOCK2	Q92608	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Array	32296183
Intra	DOCK2	Q92608	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
Intra	DOCK2	Q92608	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	25416956
Intra	DOCK2	Q92608	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	DOCK2	Q92608	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	DOCK2	Q92608	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	DOCK2	Q92608	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	DOCK2	Q92608	PCSK5	Homo sapiens	Q92824-2	Y2H Array	32296183
Intra	DOCK2	Q92608	PCSK5	Homo sapiens	Q92824-2	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	PCSK5	Homo sapiens	Q92824-2	Validated Y2H	32296183
Intra	DOCK2	Q92608	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	DOCK2	Q92608	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	DOCK2	Q92608	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP17-1	Homo sapiens	Q9BYP8	Validated Y2H	32296183
Intra	DOCK2	Q92608	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Array	32296183
Intra	DOCK2	Q92608	TENM4	Homo sapiens	Q6N022	Y2H Array	32296183
Intra	DOCK2	Q92608	TENM4	Homo sapiens	Q6N022	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	DOCK2	Q92608	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	TGM1	Homo sapiens	P22735	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	TGM1	Homo sapiens	P22735	Y2H Array	32296183
Intra	DOCK2	Q92608	HNRNPK	Homo sapiens	P61978	Y2H Prey Pooling	25416956
Intra	DOCK2	Q92608	HNRNPK	Homo sapiens	P61978	Y2H Array	25416956
Intra	DOCK2	Q92608	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	DOCK2	Q92608	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	DOCK2	Q92608	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	DOCK2	Q92608	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP3-3	Homo sapiens	Q9BYR6	Validated Y2H	32296183
Intra	DOCK2	Q92608	KRTAP3-3	Homo sapiens	Q9BYR6	Y2H Array	32296183
Intra	DOCK2	Q92608	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	DOCK2	Q92608	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	RAC1	Homo sapiens	P63000	Pull Down	15723800
Intra	DOCK2	Q92608	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	DOCK2	Q92608	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	DOCK2	Q92608	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KHDRBS3	Homo sapiens	O75525	Y2H Array	32296183
Intra	DOCK2	Q92608	KHDRBS3	Homo sapiens	O75525	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	DOCK2	Q92608	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	DOCK2	Q92608	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	DOCK2	Q92608	CALCOCO2	Homo sapiens	Q13137	Y2H Prey Pooling	25416956
Intra	DOCK2	Q92608	PLSCR1	Homo sapiens	O15162	Validated Y2H	25416956
Intra	DOCK2	Q92608	PLSCR1	Homo sapiens	O15162	Y2H Array	25416956
Intra	DOCK2	Q92608	TRIM23	Homo sapiens	P36406	Validated Y2H	25416956
Intra	DOCK2	Q92608	TRIM23	Homo sapiens	P36406	Y2H Prey Pooling	25416956
Intra	DOCK2	Q92608	HOXA1	Homo sapiens	P49639	Y2H Array	32296183
Intra	DOCK2	Q92608	HOXA1	Homo sapiens	P49639	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	PLEKHF2	Homo sapiens	Q9H8W4	Validated Y2H	32296183
Intra	DOCK2	Q92608	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	25416956
Intra	DOCK2	Q92608	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	32296183
Intra	DOCK2	Q92608	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	25416956
Intra	DOCK2	Q92608	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	25416956
Intra	DOCK2	Q92608	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	25416956
Intra	DOCK2	Q92608	CCNDBP1	Homo sapiens	O95273	Validated Y2H	25416956
Intra	DOCK2	Q92608	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	DOCK2	Q92608	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Prey Pooling	32296183
Intra	DOCK2	Q92608	KRTAP3-1	Homo sapiens	Q9BYR8	Validated Y2H	32296183
Intra	DOCK2	Q92608	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

DOCK2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82965	DOCK2 Antibody (YA2710)	WB, IHC-P	Human

Related Diseases

Diseases

Alias

Immunodeficiency 40

Dock2 Deficiency	IMD40
Immunodeficiency, Type 40

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Lymphopenia

Lymphocytopenia

Skeletal Tuberculosis

Tuberculosis, Osteoarticular

Osteoarticular Tuberculosis

Coronin-1a Deficiency

Brachydactyly, Type C

Brachydactyly Type C	BDC
Brachydactyly Haws Type	Brachydactyly, Haws Type
Brachydactyly C

Omenn Syndrome

Histiocytic Medullary Reticulosis	Severe Combined Immunodeficiency With Hypereosinophilia
Combined Immunodeficiency With Hypereosinophilia	Reticuloendotheliosis, Familial, With Eosinophilia
Reticuloendotheliosis Familial With Eosinophilia	Familial Reticuloendotheliosis
Omenn'S Syndrome	OS
Malignant Histiocytosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153128	DOCK2-IN-1	Inhibitor	96.20%	Unkown
HY-111355	Cholesterol sulfate	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DOCK2	MGD	MGI:2149010
Bos taurus	DOCK2	VGNC	VGNC:28157
Felis catus	DOCK2	VGNC	VGNC:61571
Canis familiaris	DOCK2	VGNC	VGNC:40046
Rattus norvegicus	DOCK2	RGD	RGD:1564189
Macaca mulatta	DOCK2	VGNC	VGNC:71966

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