2. Gene
  3. DOCK2 - dedicator of cytokinesis 2 Gene

DOCK2 - dedicator of cytokinesis 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IMD40

Gene ID: 1794 | Gene type: protein coding

About DOCK2

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:169,637,275-170,083,382 (from NCBI)

This gene has 18 transcripts (splice variants), 235 orthologues, 10 paralogues and is associated with 2 phenotypes. Broad expression in lymph node (RPKM 13.3), bone marrow (RPKM 11.2) and 15 other tissues.

Summary

The protein encoded by this gene belongs to the CDM protein family. It is specifically expressed in hematopoietic cells and is predominantly expressed in peripheral blood leukocytes. The protein is involved in remodeling of the actin Cytoskeleton required for lymphocyte migration in response to chemokine signaling. It activates members of the Rho family of GTPases, for example RAC1 and RAC2, by acting as a guanine nucleotide exchange factor (GEF) to exchange bound GDP for free GTP. Mutations in this gene result in immunodeficiency 40 (IMD40), a combined form of immunodeficiency that affects T cell number and function, also with variable defects in B cell and NK cell function. [provided by RefSeq, May 2018]

DOCK2 Products(1)

mRNA Protein Name
NM_004946.3 NP_004937.1 dedicator of cytokinesis protein 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables T cell receptor binding IDA
IDA: Inferred from direct assay
12176041 GOA
enables guanyl-nucleotide exchange factor activity IDA
IDA: Inferred from direct assay
10559471 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12134158 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DOCK2 Protein Structure

SH3_2

SH3_2: Variant SH3 domain (12 - 63)

DOCK-C2

DOCK-C2: C2 domain in Dock180 and Zizimin proteins (418 - 616)

DHR-2

DHR-2: Dock homology region 2 (1432 - 1614)

  • 0
  • 300
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  • 1200
  • 1500
  • 1830 a.a.
Protein Preferred Names Protein Names

dedicator of cytokinesis protein 2

dedicator of cyto-kinesis 2

DOCK2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra DOCK2 Q92608 KRT40 Homo sapiens Q6A162
Y2H Array
32296183
Intra DOCK2 Q92608 KRT40 Homo sapiens Q6A162
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP10-8 Homo sapiens P60410
Y2H Array
25416956
Intra DOCK2 Q92608 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra DOCK2 Q92608 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra DOCK2 Q92608 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra DOCK2 Q92608 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra DOCK2 Q92608 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
25416956
Intra DOCK2 Q92608 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Array
25416956
Intra DOCK2 Q92608 KRTAP9-4 Homo sapiens Q9BYQ2
Y2H Array
25416956
Intra DOCK2 Q92608 KRTAP9-4 Homo sapiens Q9BYQ2
Validated Y2H
25416956
Intra DOCK2 Q92608 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra DOCK2 Q92608 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP9-3 Homo sapiens Q9BYQ3
Validated Y2H
32296183
Intra DOCK2 Q92608 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
25416956
Intra DOCK2 Q92608 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra DOCK2 Q92608 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra DOCK2 Q92608 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra DOCK2 Q92608 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra DOCK2 Q92608 PCSK5 Homo sapiens Q92824-2
Y2H Array
32296183
Intra DOCK2 Q92608 PCSK5 Homo sapiens Q92824-2
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 PCSK5 Homo sapiens Q92824-2
Validated Y2H
32296183
Intra DOCK2 Q92608 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra DOCK2 Q92608 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Array
32296183
Intra DOCK2 Q92608 KRTAP5-7 Homo sapiens Q6L8G8
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP17-1 Homo sapiens Q9BYP8
Validated Y2H
32296183
Intra DOCK2 Q92608 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
Intra DOCK2 Q92608 TENM4 Homo sapiens Q6N022
Y2H Array
32296183
Intra DOCK2 Q92608 TENM4 Homo sapiens Q6N022
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra DOCK2 Q92608 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 TGM1 Homo sapiens P22735
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 TGM1 Homo sapiens P22735
Y2H Array
32296183
Intra DOCK2 Q92608 HNRNPK Homo sapiens P61978
Y2H Prey Pooling
25416956
Intra DOCK2 Q92608 HNRNPK Homo sapiens P61978
Y2H Array
25416956
Intra DOCK2 Q92608 CARD10 Homo sapiens Q9BWT7
Validated Y2H
32296183
Intra DOCK2 Q92608 CARD10 Homo sapiens Q9BWT7
Y2H Array
32296183
Intra DOCK2 Q92608 CARD10 Homo sapiens Q9BWT7
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra DOCK2 Q92608 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP3-3 Homo sapiens Q9BYR6
Validated Y2H
32296183
Intra DOCK2 Q92608 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra DOCK2 Q92608 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra DOCK2 Q92608 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 RAC1 Homo sapiens P63000
Pull Down
15723800
Intra DOCK2 Q92608 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
Intra DOCK2 Q92608 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 HNRNPK Homo sapiens P61978-2
Y2H Array
32296183
Intra DOCK2 Q92608 HNRNPK Homo sapiens P61978-2
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KHDRBS3 Homo sapiens O75525
Y2H Array
32296183
Intra DOCK2 Q92608 KHDRBS3 Homo sapiens O75525
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra DOCK2 Q92608 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra DOCK2 Q92608 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
Intra DOCK2 Q92608 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
Intra DOCK2 Q92608 PLSCR1 Homo sapiens O15162
Validated Y2H
25416956
Intra DOCK2 Q92608 PLSCR1 Homo sapiens O15162
Y2H Array
25416956
Intra DOCK2 Q92608 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
Intra DOCK2 Q92608 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
Intra DOCK2 Q92608 HOXA1 Homo sapiens P49639
Y2H Array
32296183
Intra DOCK2 Q92608 HOXA1 Homo sapiens P49639
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra DOCK2 Q92608 KHDRBS2 Homo sapiens Q5VWX1
Validated Y2H
25416956
Intra DOCK2 Q92608 KHDRBS2 Homo sapiens Q5VWX1
Y2H Array
32296183
Intra DOCK2 Q92608 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
25416956
Intra DOCK2 Q92608 KHDRBS2 Homo sapiens Q5VWX1
Y2H Array
25416956
Intra DOCK2 Q92608 KHDRBS2 Homo sapiens Q5VWX1
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 CCNDBP1 Homo sapiens O95273
Y2H Prey Pooling
25416956
Intra DOCK2 Q92608 CCNDBP1 Homo sapiens O95273
Validated Y2H
25416956
Intra DOCK2 Q92608 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra DOCK2 Q92608 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Intra DOCK2 Q92608 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
Intra DOCK2 Q92608 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Immunodeficiency 40

Dock2 Deficiency

IMD40

Immunodeficiency, Type 40
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
Lymphopenia

Lymphocytopenia
Skeletal Tuberculosis

Tuberculosis, Osteoarticular

Osteoarticular Tuberculosis
Coronin-1a Deficiency
Brachydactyly, Type C

Brachydactyly Type C

BDC

Brachydactyly Haws Type

Brachydactyly, Haws Type

Brachydactyly C
Omenn Syndrome

Histiocytic Medullary Reticulosis

Severe Combined Immunodeficiency With Hypereosinophilia

Combined Immunodeficiency With Hypereosinophilia

Reticuloendotheliosis, Familial, With Eosinophilia

Reticuloendotheliosis Familial With Eosinophilia

Familial Reticuloendotheliosis

Omenn'S Syndrome

OS

Malignant Histiocytosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153128 DOCK2-IN-1 Inhibitor 96.20% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus DOCK2 MGD MGI:2149010
Bos taurus DOCK2 VGNC VGNC:28157
Felis catus DOCK2 VGNC VGNC:61571
Canis familiaris DOCK2 VGNC VGNC:40046
Rattus norvegicus DOCK2 RGD RGD:1564189
Macaca mulatta DOCK2 VGNC VGNC:71966