2. Gene
  3. LRIG1 - leucine rich repeats and immunoglobulin like domains 1 Gene

LRIG1 - leucine rich repeats and immunoglobulin like domains 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LIG1; LIG-1

Gene ID: 26018 | Gene type: protein coding

About LRIG1

Cytogenetic location: 3p14.1 Genomic coordinates (GRCh38): 3:66,378,797-66,501,121 (from NCBI)

This gene has 9 transcripts (splice variants), 203 orthologues and 22 paralogues. Ubiquitous expression in brain (RPKM 61.1), fat (RPKM 28.0) and 23 other tissues.

Summary

Predicted to act upstream of or within several processes, including innervation; otolith morphogenesis; and sensory perception of sound. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

LRIG1 Products(7)

mRNA Protein Name
NM_001377344.1 NP_001364273.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 2 precursor
NM_001377345.1 NP_001364274.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3
NM_001377346.1 NP_001364275.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 3
NM_001377347.1 NP_001364276.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 4
NM_001377348.1 NP_001364277.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 5
NM_001377349.1 NP_001364278.1 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 6
NM_015541.3 NP_056356.2 leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 1 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15282549 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRIG1 Protein Structure

LRR_8

LRR_8: Leucine rich repeat (71 - 104)

LRR_8

LRR_8: Leucine rich repeat (116 - 175)

LRR_8

LRR_8: Leucine rich repeat (189 - 247)

LRR_8

LRR_8: Leucine rich repeat (308 - 367)

LRR_8

LRR_8: Leucine rich repeat (383 - 441)

LRRCT

LRRCT: Leucine rich repeat C-terminal domain (466 - 490)

I-set

I-set: Immunoglobulin I-set domain (495 - 595)

I-set

I-set: Immunoglobulin I-set domain (599 - 689)

I-set

I-set: Immunoglobulin I-set domain (694 - 780)

  • 0
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  • 800
  • 1000
  • 1093 a.a.
Protein Preferred Names Protein Names

leucine-rich repeats and immunoglobulin-like domains protein 1

leucine-rich repeat protein LRIG1

LRIG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
LRIG1 Q96JA1 EGFR Homo sapiens P00533
Anti Tag CoIP
15282549
Intra
LRIG1 Q96JA1 EGFR Homo sapiens P00533
Anti Bait CoIP
18542056
Intra
LRIG1 Q96JA1 EGFR Homo sapiens P00533
Anti Bait CoIP
15282549
Intra
LRIG1 Q96JA1 EGFR Homo sapiens P00533
Anti Tag CoIP
15345710
Intra
LRIG1 Q96JA1 CBL Homo sapiens P22681
Pull Down
15282549
Intra
LRIG1 Q96JA1 CBL Homo sapiens P22681
Anti Tag CoIP
15282549
Intra
LRIG1 Q96JA1 ERBB2 Homo sapiens P04626
Anti Tag CoIP
15282549
Intra
LRIG1 Q96JA1 ERBB2 Homo sapiens P04626
Anti Tag CoIP
15345710
Intra
LRIG1 Q96JA1 ERBB2 Homo sapiens P04626
Anti Bait CoIP
23723069
Intra
LRIG1 Q96JA1 ERBB2 Homo sapiens P04626
IF
15345710
Intra
LRIG1 Q96JA1 ERBB3 Homo sapiens P21860
Anti Tag CoIP
15282549
Intra
LRIG1 Q96JA1 ERBB4 Homo sapiens Q15303
Anti Tag CoIP
15345710
Intra
LRIG1 Q96JA1 ERBB4 Homo sapiens Q15303
Anti Tag CoIP
15282549
Intra
LRIG1 Q96JA1 LRIG3 Homo sapiens Q6UXM1
Anti Bait CoIP
23723069
Intra
LRIG1 Q96JA1 LRIG3 Homo sapiens Q6UXM1
Anti Tag CoIP
33961781
Intra
LRIG1 Q96JA1 LRIG3 Homo sapiens Q6UXM1
Anti Tag CoIP
23723069
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRIG1 Proteins

Cat. No. Product Name Accession Purity
HY-P77988 LRIG1 Protein, Human (HEK293, His) Q96JA1-1 (A35-S779) ≥95%

Related Diseases

Diseases Alias
Urofacial Syndrome 1

Urofacial Syndrome

Ochoa Syndrome

Hydronephrosis With Peculiar Facial Expression

Ufs

Inverted Smile And Occult Neuropathic Bladder

Partial Facial Palsy With Urinary Abnormalities

UFS1

Urofacial Ochoa'S Syndrome

Urofacial Syndrome Type 1

Facial Palsy, Partial, With Urinary Abnormalities

Hydronephrosis-Inverted Smile

Inverted Smile-Neurogenic Bladder

Hydronephrosis-Inverted Smile Syndrome

Inverted Smile-Neurogenic Bladder Syndrome

Partial Facial Palsy Partial With Urinary Abnormalities

Urologic Diseases
Sebaceous Adenoma

Adenoma Of The Sebaceous Gland

Skin Appendage Sebaceous Adenoma
Sebaceous Gland Neoplasm

Sebaceous Gland Neoplasms

Sebaceous Neoplasm
Hair Follicle Neoplasm

Hair Matrix Neoplasm

Hair Matrix Tumour
Colonic Benign Neoplasm

Colon Neoplasm

Colonic Mass

Colonic Tumor

Neoplasm Of Colon

Neoplasm Of The Colon

Colonic Neoplasms

Colon Cancer

Colon Carcinoma Nos

Colonic Cancer

Metastatic Colon Cancer Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07787 LRIG1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus LRIG1 RGD RGD:1306788
Macaca mulatta LRIG1 VGNC VGNC:84156
Canis familiaris LRIG1 VGNC VGNC:42767
Bos taurus LRIG1 VGNC VGNC:30982
Felis catus LRIG1 VGNC VGNC:80612
Mus musculus LRIG1 MGD MGI:107935
Macaca fascicularis LRIG1 NCBI NCBI:102140736
Others LRIG1 NCBI