1. Gene
  2. ERBB3 - erb-b2 receptor tyrosine kinase 3 Gene

ERBB3 - erb-b2 receptor tyrosine kinase 3 Gene

Homo sapiens

Also known as HER3; FERLK; LCCS2; VSCN1; ErbB-3; c-erbB3; erbB3-S; MDA-BF-1; c-erbB-3; p180-ErbB3; p45-sErbB3; p85-sErbB3

Gene ID: 2065 | Gene type: protein coding

About ERBB3

Cytogenetic location: 12q13.2 Genomic coordinates (GRCh38): 12:56,080,108-56,103,505 (from NCBI)

This gene has 33 transcripts (splice variants), 280 orthologues, 53 paralogues and is associated with 134 phenotypes. Broad expression in small intestine (RPKM 41.0), duodenum (RPKM 39.7) and 17 other tissues.

Summary

This gene encodes a member of the epidermal growth factor receptor (EGFR) family of Receptor Tyrosine Kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with Other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

ERBB3 Products(4)

mRNA Protein Name
NM_001005915.1 NP_001005915.1 receptor tyrosine-protein kinase erbB-3 isoform s precursor
XM_047428500.1 XP_047284456.1 receptor tyrosine-protein kinase erbB-3 isoform X1
NM_001982.4 NP_001973.2 receptor tyrosine-protein kinase erbB-3 isoform 1 precursor
XM_047428501.1 XP_047284457.1 receptor tyrosine-protein kinase erbB-3 isoform X1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ErbB-3 class receptor binding IPI
IPI: Inferred from physical interaction
12000754 GOA
enables growth factor binding IPI
IPI: Inferred from physical interaction
11389077 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
21575594 GOA
enables neuregulin binding IDA
IDA: Inferred from direct assay
20682778 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
7556068 GOA
enables protein heterodimerization activity IPI
IPI: Inferred from physical interaction
7556068 GOA
enables protein tyrosine kinase activator activity IDA
IDA: Inferred from direct assay
7556068 GOA
NOT enables protein tyrosine kinase activity IDA
IDA: Inferred from direct assay
7556068 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
27353365 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cell surface receptor protein tyrosine kinase signaling pathway IDA
IDA: Inferred from direct assay
7556068 GOA
involved in extrinsic apoptotic signaling pathway in absence of ligand IMP
IMP: Inferred from mutant phenotype
17701904 GOA
involved in negative regulation of cell adhesion IDA
IDA: Inferred from direct assay
7556068 GOA
involved in negative regulation of secretion IDA
IDA: Inferred from direct assay
10559227 GOA
involved in negative regulation of signal transduction IDA
IDA: Inferred from direct assay
11389077 GOA
involved in neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
17701904 GOA
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
7556068 GOA
involved in regulation of cell population proliferation IDA
IDA: Inferred from direct assay
11389077 GOA
involved in signal transduction IDA
IDA: Inferred from direct assay
10572067 GOA
Cellular Component GO Annotation Evidence Reference Source
part of ERBB3:ERBB2 complex IDA
IDA: Inferred from direct assay
12000754 GOA
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
12646923 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
11389077 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ERBB3 Protein Structure

Recep_L_domain

Recep_L_domain: Receptor L domain (56 - 166)

Furin-like

Furin-like: Furin-like cysteine rich region (182 - 332)

Recep_L_domain

Recep_L_domain: Receptor L domain (353 - 472)

GF_recep_IV

GF_recep_IV: Growth factor receptor domain IV (499 - 629)

Pkinase_Tyr

Pkinase_Tyr: Protein tyrosine kinase (710 - 964)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1342 a.a.
Protein Preferred Names Protein Names

receptor tyrosine-protein kinase erbB-3

human epidermal growth factor receptor 3

proto-oncogene-like protein c-ErbB-3

tyrosine kinase-type cell surface receptor HER3

v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3

ERBB3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ERBB3 P21860 RASA1 Homo sapiens P20936
Protein Array
16273093
Intra
ERBB3 P21860 ABL2 Homo sapiens P42684
Protein Array
16273093
Intra
ERBB3 P21860 TNS3 Homo sapiens Q68CZ2
Protein Array
16273093
Intra
ERBB3 P21860 PIK3CA Homo sapiens P42336
TAP
24189400
Intra
ERBB3 P21860 PIK3CA Homo sapiens P42336
Anti Bait CoIP
19411071
Intra
ERBB3 P21860 NRG1 Homo sapiens Q02297-7
Comig Non-Denat Gel
7592681
Intra
ERBB3 P21860 NRG1 Homo sapiens Q02297-7
Solution Sedimentation
7592681
Intra
ERBB3 P21860 EGFR Homo sapiens P00533
Anti Bait CoIP
23866081
Intra
ERBB3 P21860 EGFR Homo sapiens P00533
Anti Bait CoIP
10572067
Intra
ERBB3 P21860 EGFR Homo sapiens P00533
TAP
24189400
Intra
ERBB3 P21860 EGFR Homo sapiens P00533
Anti Bait CoIP
31862538
Intra
ERBB3 P21860 HCK Homo sapiens P08631
Protein Array
16273093
Intra
ERBB3 P21860 PIK3R2 Homo sapiens O00459
Protein Array
16273093
Intra
ERBB3 P21860 PIK3R2 Homo sapiens O00459
TAP
24189400
Intra
ERBB3 P21860 PIK3R2 Homo sapiens O00459
Pull Down
16729043
Intra
ERBB3 P21860 HSP90AB1 Homo sapiens P08238
TAP
24189400
Intra
ERBB3 P21860 RIN1 Homo sapiens Q13671
Ub Reconstruction
31980649
Intra
ERBB3 P21860 RIN1 Homo sapiens Q13671
Protein Array
16273093
Intra
ERBB3 P21860 GRB2 Homo sapiens P62993
Pull Down
16729043
Intra
ERBB3 P21860 GRB2 Homo sapiens P62993
TAP
24189400
Intra
ERBB3 P21860 GRB2 Homo sapiens P62993
Ub Reconstruction
24658140
Intra
ERBB3 P21860 SRC Homo sapiens P12931
Protein Array
16273093
Intra
ERBB3 P21860 ERBB2 Homo sapiens P04626
PLA
23436906
Intra
ERBB3 P21860 ERBB2 Homo sapiens P04626
Beta Galactosidase
17148612
Intra
ERBB3 P21860 ERBB2 Homo sapiens P04626
PLA
23688700
Intra
ERBB3 P21860 ERBB2 Homo sapiens P04626
Anti Bait CoIP
21075308
Intra
ERBB3 P21860 ERBB2 Homo sapiens P04626
Anti Bait CoIP
10572067
Intra
ERBB3 P21860 ERBB2 Homo sapiens P04626
Crosslink
19411071
Intra
ERBB3 P21860 ERBB2 Homo sapiens P04626
Anti Bait CoIP
19411071
Intra
ERBB3 P21860 ERBB2 Homo sapiens P04626
Photoaffinity Labelling
21278786
Intra
ERBB3 P21860 SYK Homo sapiens P43405
Protein Array
16273093
Intra
ERBB3 P21860 SH2B3 Homo sapiens Q9UQQ2
Protein Array
16273093
Intra
ERBB3 P21860 SHC1 Homo sapiens P29353
BioID
35384245
Intra
ERBB3 P21860 SHC1 Homo sapiens P29353
TAP
24189400
Intra
ERBB3 P21860 SHC1 Homo sapiens P29353
Pull Down
16729043
Intra
ERBB3 P21860 SHC1 Homo sapiens P29353
Protein Array
16273093
Intra
ERBB3 P21860 SHC3 Homo sapiens Q92529
Protein Array
16273093
Intra
ERBB3 P21860 PLCG1 Homo sapiens P19174
Protein Array
16273093
Intra
ERBB3 P21860 PIK3R1 Homo sapiens P27986
Anti Bait CoIP
21075308
Intra
ERBB3 P21860 PIK3R1 Homo sapiens P27986
Anti Bait CoIP
20227043
Intra
ERBB3 P21860 PIK3R1 Homo sapiens P27986
Anti Bait CoIP
21278786
Intra
ERBB3 P21860 PIK3R1 Homo sapiens P27986
Anti Bait CoIP
10572067
Intra
ERBB3 P21860 PIK3R1 Homo sapiens P27986
Protein Array
16273093
Intra
ERBB3 P21860 PIK3R1 Homo sapiens P27986
TAP
24189400
Intra
ERBB3 P21860 PIK3R3 Homo sapiens Q92569
Protein Array
16273093
Intra
ERBB3 P21860 PIK3R3 Homo sapiens Q92569
TAP
24189400
Intra
ERBB3 P21860 ERBB4 Homo sapiens Q15303
Anti Bait CoIP
10572067
Intra
ERBB3 P21860 ERBB4 Homo sapiens Q15303
Anti Bait CoIP
20227043
Intra
ERBB3 P21860 CRKL Homo sapiens P46109
Protein Array
16273093
Intra
ERBB3 P21860 TNS2 Homo sapiens Q63HR2
Protein Array
16273093
Intra
ERBB3 P21860 GRB7 Homo sapiens Q14451
TAP
24189400
Intra
ERBB3 P21860 GRB7 Homo sapiens Q14451
Competition Binding
9516479
Intra
ERBB3 P21860 GRB7 Homo sapiens Q14451
Protein Array
16273093
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ERBB3 Proteins

Cat. No. Product Name Accession Purity
HY-P70322 HER3 Protein, Human (HEK293, Fc) P21860-1 (S20-T643) ≥95%
HY-P70323 HER3 Protein, Human (312a.a, HEK293, Fc) P21860-3 (S20-F331) ≥95%
HY-P72375 HER3 Protein, Human (Biotinylated, HEK293, His-Avi) P21860-1 (S20-T643) ≥95%
HY-P72625 HER3 Protein, Human (HEK293, His) P21860-1 (S20-T643) ≥95%
HY-P74893 HER3 Protein, Human (sf9, His-GST) P21860-1/NP_001973.2 (P730-S1065) ≥95%
HY-P77554 HER3 Protein, Human (Biotinylated, HEK293, His) P21860-1/NP_001973.2 (S20-T643) ≥95%
HY-P78452 HER3 Protein, Human (HEK293, His-Avi) P21860-1 (S20-T643) ≥95%
HY-P72625A HER3 Protein, Human (HEK293, His, solution) P21860-1 (S20-T643) ≥95%

Related Diseases

Diseases Alias
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Protection Against

Lung Cancer, Susceptibility To

Adenocarcinoma Of Lung, Somatic

Nonsmall Cell Lung Cancer

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Male Breast Cancer

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Lethal Congenital Contracture Syndrome

Lccs

Lethal Congenital Contracture Syndrome 1

Esophageal Cancer

Esophageal Carcinoma

Carcinoma Of Esophagus

Esophageal Squamous Cell Carcinoma, Somatic

Esophageal Carcinoma, Somatic

Esophagus Cancer

Gastric Cardia Adenocarcinoma

Esophageal Neoplasms

Esophageal Cancer, Somatic

Cancer Of Esophagus

Cancer Of Oesophagus

Carcinoma Of Oesophagus

Ca Lower Third Oesophagus

Ca Middle Third Oesophagus

Malignant Neoplasm Of Distal Third Of Esophagus

Malignant Neoplasm Of Lower Third Of Oesophagus

Malignant Neoplasm Of Middle Third Of Oesophagus

Malignant Neoplasm Of Proximal Third Of Esophagus

Malignant Neoplasm Of Upper Third Esophagus

Malignant Tumor Of Abdominal Esophagus

Malignant Tumor Of Distal Third Of Esophagus

Malignant Tumor Of Proximal Third Of Esophagus

Malignant Tumor Of The Middle Third Of The Esophagus

ESCR

Aerodigestive Tract Cancer

Escc

Esophageal Squamous Cell Carcinoma

Cancer, Esophageal

Malignant Neoplasm Of Esophagus

Squamous Cell Carcinoma Of Esophagus

Malignant Neoplasm Of Middle Third Of Esophagus

Gastrointestinal Stromal Tumor

GIST

Gastrointestinal Stromal Tumors

Gastrointestinal Stromal Sarcoma

Gastrointestinal Stromal Tumor, Familial

Gant

Gastrointestinal Stromal Tumour

Stromal Tumor Of Gastrointestinal Tract

Stromal Tumour Of Gastrointestinal Tract

Gastrointestinal Stromal Neoplasm

Paraganglioma And Gastric Stromal Sarcoma

Plexosarcoma

Bladder Urothelial Carcinoma

Bladder Transitional Cell Carcinoma

Transitional Cell Carcinoma Of Bladder

Transitional Cell Carcinoma Of The Bladder

Urinary Bladder Urothelial Carcinoma

Urothelial Bladder Carcinoma

Carcinoma Transitional Cell Bladder

Tcc - [Transitional Cell Carcinoma] Of Bladder

Adenocarcinoma

Adenocarcinomas

Adenoacanthoma Of Unspecified Site

Adenocarcinoid Of Unspecified Site

Adenocarcinoid Tumour Of Unspecified Site

Adenocarcinoma And Carcinoid Combined Of Unspecified Site

Adenocarcinoma Nos

Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies

Vallecula Cancer

Malignant Tumor Of Vallecula

Gallbladder Signet Ring Cell Adenocarcinoma

Signet Ring Cell Carcinoma Of The Gallbladder

Acoustic Neuroma

Neurofibromatosis Type 2

Vestibular Schwannoma

Bilateral Acoustic Neurofibromatosis

Nf2

Acoustic Neurilemoma

Acoustic Neurinoma

Cerebellopontine Angle Tumor

Neurofibromatosis Central Type

Neurofibromatosis Type Ii

Vestibular Neurilemmoma

Acoustic Tumor

Neurinoma Of The Acoustic Nerve

Acoustic Neurinoma Bilateral

Acoustic Schwannomas Bilateral

Banf

Central Neurofibromatosis

Familial Acoustic Neuromas

Neurofibromatosis 2

Neurofibromatosis Type 2 Merlin

Schwannoma, Acoustic, Bilateral

Neuroma Acoustic

Neuroma, Acoustic

Familial Acoustic Neuroma

Familial Vestibular Schwannoma

Neurofibromatosis, Central Type

Nf2 - [Neurofibromatosis Type 2]

Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Pancreatic Adenocarcinoma

Adenocarcinoma Of Pancreas

Adenocarcinoma Of The Pancreas

Pancreas Adenocarcinoma

Malignant Exocrine Neoplasm

Primary Pancreatic Adenocarcinoma

Adenocarcinoma Of Islet Cell Of Pancreas

Islet Cell Adenocarcinoma Of Unspecified Site

Mixed Adenocarcinoma Islet Cell With Exocrine Of Unspecified Site

Clivus Chondroid Chordoma

Chondroid Chordoma Of The Clivus

Erythroleukemia
Cervical Cancer

Cervical Cancer, Somatic

Neoplasm Of Uterine Cervix

Cervix Cancer

Uterine Cervical Neoplasm

Cervical Neoplasm

Cervix Uteri Cancer

Tumor Of The Cervix Uteri

CERCA

Uterine Cervical Cancer

Neoplasms Cervical

Uterine Cervical Neoplasms

Cervical Cancers

Cancer, Cervical, Somatic

Malignant Tumor Of Cervix

Cervix Carcinoma

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck

HNSCC

Head And Neck Squamous Cell Carcinoma

Head And Neck Cancer

Squamous Cell Carcinoma Of Lip

Squamous Cell Carcinoma, Head And Neck, Somatic

Carcinoma Of The Head And Neck

Squamous Cell Carcinomas Of Head And Neck

Scchn

Squamous Cell Carcinoma Of The Hypopharynx

Squamous Cell Carcinoma Of The Oropharynx

Squamous Cell Carcinoma Of Salivary Glands

Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses

Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses

Squamous Cell Carcinoma Of The Oral Cavity

Squamous Cell Carcinoma Of The Lip

Carcinoma, Squamous Cell Of Head And Neck

Lip Squamous Cell Carcinoma

Cancer, Head/Neck

Carcinoma, Squamous Cell, Head And Neck

Salivary Gland Squamous Cell Carcinoma

Cancer Of Head And Neck

Squamous Cell Carcinoma Of Oropharynx Nos

Keratoconjunctivitis Sicca

Kcs

Dry Eye Syndromes

Keratitis Sicca

Xerophthalmia

Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Uterine Carcinosarcoma

Carcinosarcoma Of The Corpus Uteri

Mixed Mullerian Sarcoma Of Uterus

Malignant Mixed Müllerian Tumor Of The Corpus Uteri

Malignant Mixed Müllerian Tumor Of Corpus Uteri

Mixed Müllerian Cancer Of Corpus Uteri

Malignant Mixed Mullerian Tumor Of The Corpus Uteri

Mixed Mullerian Cancer Of Corpus Uteri

Uterine Corpus Carcinosarcoma

Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder

Clear Cell Sarcoma

Sarcoma, Clear Cell

Adult Soft Part Clear Cell Sarcoma

Clear Cell Sarcoma Of Soft Parts

Malignant Melanoma Of Soft Parts

Malignant Melanoma Of Soft Tissues

Melanoma, Malignant, Of Soft Parts

Sarcoma Clear Cell

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Ganglioneuroma
Gastroesophageal Adenocarcinoma

Gastric And Esophageal Adenocarcinoma

Gastro-Esophageal Adenocarcinoma

Ovarian Cancer

Ovarian Carcinoma

Ovarian Neoplasm

Malignant Tumour Of Ovary

Epithelial Ovarian Cancer

Neoplasm Of Ovary

Ovarian Neoplasms

Ovarian Cancers

Malignant Neoplasm Of Ovary

Primary Malignant Neoplasm Of Ovary

Ovarian Cancer, Somatic

Malignant Ovarian Tumor

Ovary Neoplasm

Primary Ovarian Cancer

Tumor Of The Ovary

Cancer Of The Ovary

Malignant Neoplasm Of The Ovary

Malignant Tumor Of The Ovary

Ovarian Malignant Tumor

OC

Ovarian Carcinomas

Cancer, Ovarian

Cancer Of Ovary

Ovary Cancer

Ca Ovary

Gastroesophageal Junction Adenocarcinoma

Adenocarcinoma Of Cardioesophageal Junction

Adenocarcinoma Of Gastroesophageal Junction

Adenocarcinoma Of The Gastroesophageal Junction

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Hypoganglionosis

Intestinal Hypoganglionosis

Acneiform Dermatitis

Dermatitis Acneiform

Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma

Ovary Transitional Cell Carcinoma

Malignant Ovarian Transitional Cell Neoplasm

Ovarian Transitional Cell Cancer

Ovarian Transitional Cell Neoplasm

Transitional Cell Carcinoma Of Ovary

Ovarian Transitional Cell Carcinoma

Malignant Ovarian Transitional Cell Tumor

Ovarian Transitional Cell Tumor

Gastric Adenocarcinoma

Adenocarcinoma Of Stomach

Stomach Adenocarcinoma

Adenocarcinoma Gastric

Intestinal Type Adenocarcinoma Of Unspecified Site

Diffuse Type Adenocarcinoma Of Unspecified Site

Neurogenic Bladder

Neurogenic Dysfunction Of The Urinary Bladder

Neurogenic Urinary Bladder Disorder

Neuropathic Bladder

Bladder Neurogenic

Urinary Bladder, Neurogenic

Neurogenic Urinary Bladder

Lethal Congenital Contracture Syndrome 2

LCCS2

Lethal Congenital Contractural Syndrome 2

Multiple Contracture Syndrome, Israeli-Bedouin Type

Multiple Contracture Syndrome, Israeli Bedouin Type A

Multiple Contracture Syndrome, Israeli Bedouin Type

Lethal Congenital Contracture Syndrome Type 2

Israeli Bedouin Multiple Contracture Syndrome Type A

Contracture Syndrome, Lethal, Congenital, Type 2

Squamous Blepharitis
Ganglioneuroblastoma
Gastric Cancer

Stomach Cancer

Stomach Carcinoma

Gastric Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach

Schizophrenia

SCZD

Schizophrenia With Or Without An Affective Disorder

Schizophrenia 12

Schizophrenia, Susceptibility To

Schizophrenia-1

Dementia Praecox

Schizophrenia 1

Colonic Benign Neoplasm

Colon Neoplasm

Colonic Mass

Colonic Tumor

Neoplasm Of Colon

Neoplasm Of The Colon

Colonic Neoplasms

Colon Cancer

Colon Carcinoma Nos

Colonic Cancer

Metastatic Colon Cancer Nos

Erythroleukemia, Familial

FERLK

Erythroleukemia, Familial, Susceptibility To

Di Guglielmo Disease, Familial

Leukemia, Acute Myelogenous, M6

{Erythroleukemia, Familial, Susceptibility To}

Acute Erythroblastic Leukemia

Mucinous Lung Adenocarcinoma
Lung Cancer Susceptibility 3

Lung Adenocarcinoma

Adenocarcinoma Of Lung

LNCR3

Adenocarcinoma Of Lung, Susceptibility To

Bronchogenic Lung Adenocarcinoma

Nonsmall Cell Adenocarcinoma

Adenocarcinoma Lung

Lung Adenocarcinomas

Non-Small Cell Adenocarcinoma

Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Congenital Megacolon

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

Hirschsprung'S Disease

Congenital Intestinal Aganglionosis

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon

Visceral Neuropathy, Familial, 1, Autosomal Recessive

VSCN1

Intestinal Pseudoobstruction Due To Neuronal Disease

Argyrophil Myenteric Plexus, Deficiency Of

Pseudoobstruction, Chronic Idiopathic Intestinal, Neuronal Type

Parkinson Disease 2, Autosomal Recessive Juvenile

Young-Onset Parkinson Disease

PARK2

Pdj

Autosomal Recessive Juvenile Parkinson Disease 2

Epdf

Parkinson Disease, Juvenile, Type 2

Parkinson'S Disease 2

Autosomal Recessive Juvenile Parkinson Disease

Early-Onset Parkinson Disease

Parkinson Disease 2

Parkinson Disease, Juvenile, Autosomal Recessive

Parkinsonism, Early-Onset, With Diurnal Fluctuation

Autosomal Recessive Juvenile Parkinson'S Disease 2

Jp

Juvenile Parkinsonism

Parkinson Disease Autosomal Recessive, Early Onset

Parkinsonism, Early Onset, With Diurnal Fluctuation

Yopd

Autosomal Recessive Early-Onset Parkinson Disease Type 2

Chromosome 6-Linked Autosomal Recessive Parkinsonism

Early-Onset Parkinsonism With Diurnal Fluctuation

Parkinsonism Young Adult Onset

Parkinson Disease, Type 2

Parkinsonism, Juvenile

Diarrhea

Diarrhoea

Diarrhea Of Presumed Infectious Origin

Female Breast Cancer

Female Breast Carcinoma

Carcinoma Of Female Breast

Mammary Carcinoma Of Female Breast

Malignant Neoplasm Of Female Breast

Gallbladder Cancer

Gallbladder Carcinoma

Gallbladder Neoplasm

Malignant Neoplasm Of Gallbladder

Malignant Tumour Of Gallbladder

Gallbladder Ca

Localized Malignant Gallbladder Neoplasm

Malignant Tumor Of The Gallbladder

Tumor Of The Gallbladder

Cancer Of The Gallbladder

Carcinoma Gallbladder

Carcinoma Of Gallbladder

Gallbladder Neoplasms

Malignant Neoplasm Of Gallbladder Localized

Cancer Of Gallbladder

Primary Malignant Neoplasm Of Gallbladder

Transitional Cell Carcinoma

Transitional Cell Neoplasm

Carcinoma, Transitional Cell

Transitional Carcinoma

Transitional Cell Tumor

Urothelial Cell Carcinoma

Carcinoma Transitional Cell

Transitional Cell Carcinoma Of Bladder

Combined Oxidative Phosphorylation Deficiency 13

COXPD13

Combined Oxidative Phosphorylation Defect Type 13

Combined Oxidative Phosphorylation Deficiency, Type 13

Breast Ductal Carcinoma

Ductal Breast Carcinoma

Duct Carcinoma

Carcinoma, Ductal

Mammary Ductal Carcinoma

Ductal Carcinoma

Bronchiectasis 2
Childhood Medulloblastoma

Medulloblastoma, Childhood

Pediatric Medulloblastoma

Medulloblastoma Childhood

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ERBB3 RGD RGD:69323
Felis catus ERBB3 VGNC VGNC:83875
Mus musculus ERBB3 MGD MGI:95411
Bos taurus ERBB3 VGNC VGNC:28564
Canis familiaris ERBB3 VGNC VGNC:54147
Macaca mulatta ERBB3 VGNC VGNC:108514
Others ERBB3 NCBI