1. Gene
  2. WSB1 - WD repeat and SOCS box containing 1 Gene

WSB1 - WD repeat and SOCS box containing 1 Gene

Homo sapiens

Also known as SWIP1; WSB-1

Gene ID: 26118 | Gene type: protein coding

About WSB1

Cytogenetic location: 17q11.1 Genomic coordinates (GRCh38): 17:27,294,114-27,315,926 (from NCBI)

This gene has 17 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 64.5), lung (RPKM 63.6) and 25 other tissues.

Summary

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

WSB1 Products(3)

mRNA Protein Name
NM_001348350.2 NP_001335279.1 WD repeat and SOCS box-containing protein 1 isoform 3
NM_015626.10 NP_056441.6 WD repeat and SOCS box-containing protein 1 isoform 1
NM_134265.4 NP_599027.1 WD repeat and SOCS box-containing protein 1 isoform 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18093972 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WSB1 Protein Structure

WD40

WD40: WD domain, G-beta repeat (161 - 199)

WD40

WD40: WD domain, G-beta repeat (207 - 242)

WD40

WD40: WD domain, G-beta repeat (249 - 284)

WD40

WD40: WD domain, G-beta repeat (308 - 338)

WD40

WD40: WD domain, G-beta repeat (356 - 378)

SOCS_box

SOCS_box: SOCS box (384 - 420)

  • 0
  • 100
  • 200
  • 300
  • 421 a.a.
Protein Preferred Names Protein Names

WD repeat and SOCS box-containing protein 1

SOCS box-containing WD protein SWiP-1

WSB1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
WSB1 Q9Y6I7 VHL Homo sapiens P40337-2 32814053
Intra
WSB1 Q9Y6I7 VHL Homo sapiens P40337-2 32814053
Intra
WSB1 Q9Y6I7 VHL Homo sapiens P40337-2 32814053
Cross
WSB1 Q9Y6I7 Hipk2 Mus musculus Q9QZR5 18093972
Cross
WSB1 Q9Y6I7 Hipk2 Mus musculus Q9QZR5 18093972
Intra
WSB1 Q9Y6I7 LRRK2 Homo sapiens Q5S007 27273569
Cross: Cross-species interaction Intra: Intraspecies interaction

Orthologs Information

Species Symbol Source ID
Mus musculus WSB1 MGD MGI:1926139
Macaca mulatta WSB1 VGNC VGNC:79186
Felis catus WSB1 VGNC VGNC:67091
Canis familiaris WSB1 VGNC VGNC:48435
Bos taurus WSB1 VGNC VGNC:36971
Rattus norvegicus WSB1 RGD RGD:1307835