WSB1 - WD repeat and SOCS box containing 1 Gene

Homo sapiens

Also known as SWIP1; WSB-1

Gene ID: 26118 | Gene type: protein coding

About WSB1

Cytogenetic location: 17q11.1 Genomic coordinates (GRCh38): 17:27,294,114-27,315,926 (from NCBI)

This gene has 17 transcripts (splice variants), 214 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 64.5), lung (RPKM 63.6) and 25 other tissues.

Summary

This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

WSB1 Products(3)

mRNA	Protein	Name
NM_001348350.2	NP_001335279.1	WD repeat and SOCS box-containing protein 1 isoform 3
NM_015626.10	NP_056441.6	WD repeat and SOCS box-containing protein 1 isoform 1
NM_134265.4	NP_599027.1	WD repeat and SOCS box-containing protein 1 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18093972	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WSB1 Protein Structure

WD40

SOCS_box

0
100
200
300
421 a.a.

Protein Preferred Names

Protein Names

WD repeat and SOCS box-containing protein 1

SOCS box-containing WD protein SWiP-1

WSB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WSB1	Q9Y6I7	VHL	Homo sapiens	P40337-2	Validated Y2H	32814053
Intra	WSB1	Q9Y6I7	VHL	Homo sapiens	P40337-2	Y2H Array	32814053
Intra	WSB1	Q9Y6I7	VHL	Homo sapiens	P40337-2	Y2H Pooling	32814053
Cross	WSB1	Q9Y6I7	Hipk2	Mus musculus	Q9QZR5	Anti Tag CoIP	18093972
Cross	WSB1	Q9Y6I7	Hipk2	Mus musculus	Q9QZR5	Pull Down	18093972
Intra	WSB1	Q9Y6I7	LRRK2	Homo sapiens	Q5S007	Confocal	27273569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141482	WSB1 Degrader 1	Inhibitor	99.81%	Unkown
HY-RS15849	WSB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WSB1	MGD	MGI:1926139
Macaca mulatta	WSB1	VGNC	VGNC:79186
Felis catus	WSB1	VGNC	VGNC:67091
Canis familiaris	WSB1	VGNC	VGNC:48435
Bos taurus	WSB1	VGNC	VGNC:36971
Rattus norvegicus	WSB1	RGD	RGD:1307835

Name
Email *

	Sorry, but the email address you supplied was invalid.