NOC2L - NOC2 like nucleolar associated transcriptional repressor Gene

Homo sapiens

Also known as NIR; NET7; NET15; PPP1R112

Gene ID: 26155 | Gene type: protein coding

About NOC2L

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:944,203-959,256 (from NCBI)

This gene has 6 transcripts (splice variants) and 193 orthologues. Ubiquitous expression in testis (RPKM 23.1), skin (RPKM 20.4) and 25 other tissues.

Summary

Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of Histone Acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]

NOC2L Products(1)

mRNA	Protein	Name
NM_015658.4	NP_056473.3	nucleolar complex protein 2 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	16322561	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	16322561	GOA
enables histone binding	IDA IDA: Inferred from direct assay	16322561	GOA
enables nucleosome binding	IDA IDA: Inferred from direct assay	16322561	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16322561	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	16322561	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to UV	IDA IDA: Inferred from direct assay	20959462	GOA
involved in negative regulation of B cell apoptotic process	IMP IMP: Inferred from mutant phenotype	20959462	GOA
involved in negative regulation of intrinsic apoptotic signaling pathway	IMP IMP: Inferred from mutant phenotype	16322561	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20123734	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	16322561	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	20123734	GOA
located in nucleoplasm	IDA IDA: Inferred from direct assay	20123734	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16322561	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOC2L Protein Structure

Noc2

0
200
400
600
749 a.a.

Protein Preferred Names

Protein Names

nucleolar complex protein 2 homolog

NOC2-like protein

NOC2L Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NOC2L	Q9Y3T9	TP53	Homo sapiens	P04637	Anti Bait CoIP	16322561
Intra	NOC2L	Q9Y3T9	TP53	Homo sapiens	P04637	Anti Tag CoIP	16322561
Intra	NOC2L	Q9Y3T9	TP53	Homo sapiens	P04637	Pull Down	16322561

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Epiphyseal Chondrodysplasia, Miura Type

ECDM	Tall Stature-Scoliosis-Macrodactyly Of The Great Toes Syndrome
Miura Type Epiphyseal Chondrodysplasia	Tall Stature-Scoliosis-Macrodactyly Of The Halluces Syndrome
Tall Stature-Long Halluces-Multiple Extra-Epiphyses Syndrome	Chondrodysplasia, Epiphyseal, Miura Type

Interstitial Nephritis, Karyomegalic

Karyomegalic Interstitial Nephritis	KMIN
Kin	Systemic Karyomegaly
Karyomegalic Tubulointerstitial Nephritis	Ktn

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09400	NOC2L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NOC2L	VGNC	VGNC:63845
Bos taurus	NOC2L	VGNC	VGNC:32146
Canis familiaris	NOC2L	VGNC	VGNC:43873
Rattus norvegicus	NOC2L	RGD	RGD:1309387
Mus musculus	NOC2L	MGD	MGI:1931051
Macaca mulatta	NOC2L	VGNC	VGNC:75245

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