2. Gene
  3. FBXO2 - F-box protein 2 Gene

FBXO2 - F-box protein 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as FBG1; FBX2; Fbs1; OCP1; NFB42

Gene ID: 26232 | Gene type: protein coding

About FBXO2

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,648,387-11,654,429 (from NCBI)

This gene has 6 transcripts (splice variants), 186 orthologues and 5 paralogues. Biased expression in brain (RPKM 27.1), adrenal (RPKM 10.3) and 11 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is highly similar to the rat NFB42 (neural F Box 42 kDa) protein which is enriched in the nervous system and may play a role in maintaining neurons in a postmitotic state. [provided by RefSeq, Jul 2008]

FBXO2 Products(1)

mRNA Protein Name
NM_012168.6 NP_036300.2 F-box only protein 2
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
21378169 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO2 Protein Structure

F-box-like

F-box-like: F-box-like (48 - 88)

FBA

FBA: F-box associated region (110 - 295)

  • 0
  • 100
  • 200
  • 296 a.a.
Protein Preferred Names Protein Names

F-box only protein 2

F-box gene 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04797 FBXO2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FBXO2 VGNC VGNC:49675
Rattus norvegicus FBXO2 RGD RGD:621751
Bos taurus FBXO2 VGNC VGNC:28897
Mus musculus FBXO2 MGD MGI:2446216
Macaca mulatta FBXO2 VGNC VGNC:72486
Felis catus FBXO2 VGNC VGNC:107540