2. Gene
  3. FBXO22 - F-box protein 22 Gene

FBXO22 - F-box protein 22 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as FBX22; FISTC1

Gene ID: 26263 | Gene type: protein coding

About FBXO22

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,903,878-75,942,511 (from NCBI)

This gene has 9 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in prostate (RPKM 5.0), kidney (RPKM 4.8) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

FBXO22 Products(2)

mRNA Protein Name
NM_012170.4 NP_036302.1 F-box only protein 22 isoform b
NM_147188.3 NP_671717.1 F-box only protein 22 isoform a
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21145461 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO22 Protein Structure

F-box

F-box: F-box domain (28 - 63)

FIST_C

FIST_C: FIST C domain (298 - 365)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

F-box only protein 22

F-box protein FBX22p44

FBXO22 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FBXO22 Q8NEZ5 SKP1 Homo sapiens P63208
Y2H Array
32296183
Intra
FBXO22 Q8NEZ5 SKP1 Homo sapiens P63208
Y2H Prey Pooling
32296183
Intra
FBXO22 Q8NEZ5 SKP1 Homo sapiens P63208
Anti Tag CoIP
26496610
Intra
FBXO22 Q8NEZ5 CUL1 Homo sapiens Q13616
Anti Tag CoIP
21145461
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-163807 22-SLF Degrader / Unkown
HY-RS04799 FBXO22 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FBXO22 MGD MGI:1926014
Bos taurus FBXO22 VGNC VGNC:28899
Felis catus FBXO22 VGNC VGNC:62181
Rattus norvegicus FBXO22 RGD RGD:1306664
Canis familiaris FBXO22 VGNC VGNC:40767