2. Gene
  3. FBXO22 - F-box protein 22 Gene

FBXO22 - F-box protein 22 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as FBX22; FISTC1

Gene ID: 26263 | Gene type: protein coding

About FBXO22

Cytogenetic location: 15q24.2 Genomic coordinates (GRCh38): 15:75,903,878-75,942,511 (from NCBI)

This gene has 9 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in prostate (RPKM 5.0), kidney (RPKM 4.8) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and, as a transcriptional target of the tumor protein p53, is thought to be involved in degradation of specific proteins in response to p53 induction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

FBXO22 Products(2)

mRNA Protein Name
NM_012170.4 NP_036302.1 F-box only protein 22 isoform b
NM_147188.3 NP_671717.1 F-box only protein 22 isoform a
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
21145461 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO22 Protein Structure

F-box

F-box: F-box domain (28 - 63)

FIST_C

FIST_C: FIST C domain (298 - 365)

  • 0
  • 100
  • 200
  • 300
  • 403 a.a.
Protein Preferred Names Protein Names

F-box only protein 22

F-box protein FBX22p44

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-163807 22-SLF Degrader / Unkown
HY-RS04799 FBXO22 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus FBXO22 MGD MGI:1926014
Bos taurus FBXO22 VGNC VGNC:28899
Felis catus FBXO22 VGNC VGNC:62181
Rattus norvegicus FBXO22 RGD RGD:1306664
Canis familiaris FBXO22 VGNC VGNC:40767