2. Gene
  3. FBXO9 - F-box protein 9 Gene

FBXO9 - F-box protein 9 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as FBX9; VCIA1; NY-REN-57; dJ341E18.2

Gene ID: 26268 | Gene type: protein coding

About FBXO9

Cytogenetic location: 6p12.1 Genomic coordinates (GRCh38): 6:53,057,802-53,100,873 (from NCBI)

This gene has 13 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in adrenal (RPKM 15.5), bone marrow (RPKM 13.7) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates at least 3 transcript variants diverging at the 5' terminus. [provided by RefSeq, Jul 2008]

FBXO9 Products(3)

mRNA Protein Name
NM_012347.4 NP_036479.1 F-box only protein 9 isoform 1
NM_033480.3 NP_258441.1 F-box only protein 9 isoform 2
NM_033481.3 NP_258442.2 F-box only protein 9 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22632967 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
34480022 GOA
Biological Process GO Annotation Evidence Reference Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
23263282 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
34480022 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
34480022 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
23263282 GOA
involved in regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
23263282 GOA
Cellular Component GO Annotation Evidence Reference Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
23263282 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
23263282 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO9 Protein Structure

F-box-like

F-box-like: F-box-like (188 - 238)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 447 a.a.
Protein Preferred Names Protein Names

F-box only protein 9

F-box protein Fbx9

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04815 FBXO9 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FBXO9 VGNC VGNC:62199
Rattus norvegicus FBXO9 RGD RGD:1310374
Bos taurus FBXO9 VGNC VGNC:28921
Macaca mulatta FBXO9 VGNC VGNC:72492
Mus musculus FBXO9 MGD MGI:1918788
Canis familiaris FBXO9 VGNC VGNC:40791