2. Gene
  3. EEF2 - eukaryotic translation elongation factor 2 Gene

EEF2 - eukaryotic translation elongation factor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as EF2; EF-2; EEF-2; SCA26

Gene ID: 1938 | Gene type: protein coding

About EEF2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,976,056-3,985,463 (from NCBI)

This gene has 7 transcripts (splice variants), 222 orthologues, 18 paralogues and is associated with 3 phenotypes. Ubiquitous expression in ovary (RPKM 918.2), thyroid (RPKM 609.1) and 25 other tissues.

Summary

This gene encodes a member of the GTP-binding translation elongation factor family. This protein is an essential factor for protein synthesis. It promotes the GTP-dependent translocation of the nascent protein chain from the A-site to the P-site of the ribosome. This protein is completely inactivated by EF-2 kinase phosporylation. [provided by RefSeq, Jul 2008]

EEF2 Products(1)

mRNA Protein Name
NM_001961.4 NP_001952.1 elongation factor 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GTPase activity IDA
IDA: Inferred from direct assay
26593721 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19417104 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
23823123 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
23636399 GOA
enables translation elongation factor activity IDA
IDA: Inferred from direct assay
26593721 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
23184662 GOA
involved in translational elongation IDA
IDA: Inferred from direct assay
26593721 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25064856 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
18809582 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EEF2 Protein Structure

GTP_EFTU

GTP_EFTU: Elongation factor Tu GTP binding domain (18 - 299)

GTP_EFTU_D2

GTP_EFTU_D2: Elongation factor Tu domain 2 (410 - 484)

EFG_II

EFG_II: Elongation Factor G, domain II (503 - 565)

EFG_IV

EFG_IV: Elongation factor G, domain IV (621 - 737)

EFG_C

EFG_C: Elongation factor G C-terminus (739 - 827)

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  • 858 a.a.
Protein Preferred Names Protein Names

elongation factor 2

epididymis secretory sperm binding protein

EEF2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
EEF2 P13639 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
EEF2 P13639 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
EEF2 P13639 HTT Homo sapiens P42858
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spinocerebellar Ataxia 26

Spinocerebellar Ataxia Type 26

SCA26

Ataxia, Spinocerebellar, Type 26
Diphtheria

Corynebacterium Infections

Corynebacterium Infection

Diphtherial Infection

Infection Due To Corynebacterium Diphtheriae
Refractory Hairy Cell Leukemia
Refractory Hematologic Cancer

Refractory Hematologic Malignancy
Fusariosis

Fusarium Infection
Retinal Melanoma

Malignant Retinal Melanoma

Malignant Melanoma Of Retina
Cerebellar Ataxia Type 41

Sca41
Myopathy, Tubular Aggregate, 1

Tubular Aggregate Myopathy

Tam

Myopathy With Tubular Aggregates

TAM1

Myopathy, Tubular Aggregate

Tubular Aggregate Myopathy 1
Alzheimer Disease, Familial, 1

Alzheimer Disease

Alzheimer'S Disease

Presenile And Senile Dementia

AD1

Alzheimer Disease, Susceptibility To

Alzheimer Disease, Late-Onset, Susceptibility To

Alzheimer Disease 1, Familial

AD

Familial Alzheimer Disease

Alzheimer Disease, Late-Onset

Alzheimers Dementia

Alzheimer Dementia

Alzheimer Sclerosis

Alzheimer Syndrome

Alzheimer-Type Dementia

Dat

Primary Senile Degenerative Dementia

Sdat

Alzheimer Disease 1

Autosomal Dominant Alzheimer Disease

Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy

Late Onset Alzheimer Disease

Alzheimers Disease

Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy

Late-Onset Alzheimers Disease

Alzheimer'S Disease Pathway Kegg

Dementia Due To Alzheimer'S Disease

Alzheimer Disease Type 1

Alzheimers
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-117684 Cabamiquine Inhibitor 99.93% Phase 2
HY-117684A Cabamiquine succinate Inhibitor 99.99% Phase 2
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-110096 A-484954 Inhibitor 99.34% Unkown
HY-100576 NH125 Inhibitor 99.81% Unkown
HY-126396 Sordarin sodium Inhibitor ≥99.0% Unkown
HY-146324 PROTAC eEF2K degrader-1 98.64% Unkown
HY-120904 AMPK-IN-1 Activator 95.19% Unkown
HY-112393 TX-1918 Inhibitor / Unkown
HY-121828 TX-1123 Inhibitor / Unkown
HY-123024 Cefatrizine / Unkown
HY-168029 eEF2K degrader-1 Degrader / Unkown
HY-RS04180 EEF2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS04181 EEF2K Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus EEF2 RGD RGD:61979
Canis familiaris EEF2 VGNC VGNC:40209
Mus musculus EEF2 MGD MGI:95288
Bos taurus EEF2 VGNC VGNC:28335
Felis catus EEF2 VGNC VGNC:78444
Macaca mulatta EEF2 VGNC VGNC:97763
Others EEF2 NCBI