FBXO6 - F-box protein 6 Gene

Homo sapiens

Also known as FBG2; FBS2; FBX6; Fbx6b

Gene ID: 26270 | Gene type: protein coding

About FBXO6

Cytogenetic location: 1p36.22 Genomic coordinates (GRCh38): 1:11,664,200-11,674,354 (from NCBI)

This gene has 3 transcripts (splice variants), 97 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 5.5), appendix (RPKM 4.6) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class, and its C-terminal region is highly similar to that of rat NFB42 (neural F Box 42 kDa) which may be involved in the control of the cell cycle. [provided by RefSeq, Jul 2008]

FBXO6 Products(1)

mRNA	Protein	Name
NM_018438.6	NP_060908.1	F-box only protein 6

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19716789	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	19716789	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	19716789	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	19716789	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXO6 Protein Structure

F-box-like

FBA

0
100
200
293 a.a.

Protein Preferred Names

Protein Names

F-box only protein 6

F-box protein FBG2

FBXO6 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	FBXO6	Q9NRD1	SKP1	Homo sapiens	P63208	Y2H Array	32296183
Intra	FBXO6	Q9NRD1	SKP1	Homo sapiens	P63208	Pull Down	30833792
Intra	FBXO6	Q9NRD1	SKP1	Homo sapiens	P63208	Y2H Prey Pooling	32296183
Intra	FBXO6	Q9NRD1	LGALS3BP	Homo sapiens	Q08380	Pull Down	30833792
Intra	FBXO6	Q9NRD1	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	28514442
Intra	FBXO6	Q9NRD1	CUL1	Homo sapiens	Q13616	Pull Down	30833792
Intra	FBXO6	Q9NRD1	CUL1	Homo sapiens	Q13616	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ngly1-Deficiency

Deficiency Of N-Glycanase 1	Ngly1-Cddg
Alacrimia-Choreoathetosis-Liver Dysfunction Syndrome	Ngly1 Deficiency
Congenital Disorder Of Deglycosylation	Congenital Disorder Of Glycosylation Type Iv
Congenital Disorder Of Deglycosylation	Cddg
Congenital Disorder Of Glycosylation Type Iv	Cdg1v

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04812	FBXO6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FBXO6	MGD	MGI:1354743
Bos taurus	FBXO6	VGNC	VGNC:28918
Rattus norvegicus	FBXO6	RGD	RGD:620418
Canis familiaris	FBXO6	VGNC	VGNC:40788
Macaca mulatta	FBXO6	VGNC	VGNC:72490
Felis catus	FBXO6	VGNC	VGNC:62197

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