GNL3 - G protein nucleolar 3 Gene

Homo sapiens

Also known as NS; E2IG3; NNP47; C77032

Gene ID: 26354 | Gene type: protein coding

About GNL3

Cytogenetic location: 3p21.1 Genomic coordinates (GRCh38): 3:52,685,920-52,694,497 (from NCBI)

This gene has 12 transcripts (splice variants), 203 orthologues and 6 paralogues. Ubiquitous expression in urinary bladder (RPKM 35.8), prostate (RPKM 32.9) and 25 other tissues.

Summary

The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

GNL3 Products(3)

mRNA	Protein	Name
NM_014366.5	NP_055181.3	guanine nucleotide-binding protein-like 3 isoform 1
NM_206825.2	NP_996561.1	guanine nucleotide-binding protein-like 3 isoform 2
NM_206826.1	NP_996562.1	guanine nucleotide-binding protein-like 3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables mRNA 5'-UTR binding	IDA IDA: Inferred from direct assay	16213212	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16097049	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of miRNA transcription	IMP IMP: Inferred from mutant phenotype	25569094	GOA
involved in positive regulation of protein localization to chromosome, telomeric region	IMP IMP: Inferred from mutant phenotype	22641345	GOA
involved in positive regulation of protein sumoylation	IMP IMP: Inferred from mutant phenotype	22641345	GOA
involved in positive regulation of telomere maintenance	IMP IMP: Inferred from mutant phenotype	22641345	GOA
involved in stem cell division	IDA IDA: Inferred from direct assay	25522312	GOA
involved in stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	25522312	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleolus	IDA IDA: Inferred from direct assay	22641345	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNL3 Protein Structure

GN3L_Grn1

MMR_HSR1

0
100
200
300
400
500
549 a.a.

Protein Preferred Names

Protein Names

guanine nucleotide-binding protein-like 3

E2-induced gene 3 protein

GNL3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GNL3	Q9BVP2	TERT	Homo sapiens	O14746	IF	24550003
Intra	GNL3	Q9BVP2	AGO2	Homo sapiens	Q9UKV8	Anti Tag CoIP	24550003
Intra	GNL3	Q9BVP2	PPP2R5A	Homo sapiens	Q15172	Y2H	16097049
Intra	GNL3	Q9BVP2	CEP19	Homo sapiens	Q96LK0	Y2H Array	32296183
Intra	GNL3	Q9BVP2	CEP19	Homo sapiens	Q96LK0	Y2H Prey Pooling	32296183
Intra	GNL3	Q9BVP2	NLE1	Homo sapiens	Q9NVX2	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Tibial Adamantinoma

Tibial Adamantinoma Morphology

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05566	GNL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05567	GNL3L Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GNL3	VGNC	VGNC:73038
Canis familiaris	GNL3	VGNC	VGNC:41327
Rattus norvegicus	GNL3	RGD	RGD:631354
Felis catus	GNL3	VGNC	VGNC:62626
Bos taurus	GNL3	VGNC	VGNC:29473
Mus musculus	GNL3	MGD	MGI:1353651

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