PPP2R5A - protein phosphatase 2 regulatory subunit B'alpha Gene

Homo sapiens

Also known as B56A; PR61A; B56alpha

Gene ID: 5525 | Gene type: protein coding

About PPP2R5A

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,285,410-212,361,853 (from NCBI)

This gene has 5 transcripts (splice variants), 206 orthologues and 4 paralogues. Ubiquitous expression in fat (RPKM 41.9), lung (RPKM 33.2) and 25 other tissues.

Summary

The product of this gene belongs to the Phosphatase 2A regulatory subunit B family. Protein Phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core Enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B56 subfamily. Alternative transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Dec 2010]

PPP2R5A Products(2)

mRNA	Protein	Name
NM_001199756.2	NP_001186685.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 2
NM_006243.4	NP_006234.1	serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kinase binding	IPI IPI: Inferred from physical interaction	21075214	GOA
enables phosphoprotein phosphatase activity	IDA IDA: Inferred from direct assay	24157919	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7592815	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of lipid kinase activity	IMP IMP: Inferred from mutant phenotype	21075214	GOA
involved in negative regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	21075214	GOA
involved in protein dephosphorylation	IDA IDA: Inferred from direct assay	24157919	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	19131648	GOA
located in centrosome	IDA IDA: Inferred from direct assay	24157919	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	21075214	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	15569306	GOA
part of protein phosphatase type 2A complex	IDA IDA: Inferred from direct assay	17245430	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP2R5A Protein Structure

B56

0
100
200
300
400
486 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

PR61alpha

PPP2R5A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PPP2R5A	Q15172	C1orf21	Homo sapiens	Q9H246	Y2H Array	32296183
Intra	PPP2R5A	Q15172	C1orf21	Homo sapiens	Q9H246	Y2H Prey Pooling	32296183
Intra	PPP2R5A	Q15172	C1orf21	Homo sapiens	Q9H246	Validated Y2H	32296183
Intra	PPP2R5A	Q15172	CHEK2	Homo sapiens	O96017	Phage Display	37219487
Intra	PPP2R5A	Q15172	SHFL	Homo sapiens	Q9NUL5-4	Validated Y2H	32296183
Intra	PPP2R5A	Q15172	TNNT2	Homo sapiens	P45379-11	Y2H Prey Pooling	32296183
Intra	PPP2R5A	Q15172	TNNT2	Homo sapiens	P45379-11	Y2H Array	32296183
Intra	PPP2R5A	Q15172	ERICH4	Homo sapiens	A6NGS2	Y2H Prey Pooling	32296183
Intra	PPP2R5A	Q15172	ERICH4	Homo sapiens	A6NGS2	Y2H Array	32296183
Intra	PPP2R5A	Q15172	PPP2R1A	Homo sapiens	P30153	TAP	18782753
Intra	PPP2R5A	Q15172	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	33961781
Intra	PPP2R5A	Q15172	PPP2R1B	Homo sapiens	P30154	Anti Tag CoIP	17540176
Intra	PPP2R5A	Q15172	PPP2R1B	Homo sapiens	P30154	TAP	18782753
Intra	PPP2R5A	Q15172	AXIN2	Homo sapiens	Q9Y2T1	Validated Y2H	32296183
Intra	PPP2R5A	Q15172	AXIN2	Homo sapiens	Q9Y2T1	Y2H Array	32296183
Intra	PPP2R5A	Q15172	AXIN2	Homo sapiens	Q9Y2T1	Y2H Prey Pooling	32296183
Intra	PPP2R5A	Q15172	GNL3	Homo sapiens	Q9BVP2	Anti Bait CoIP	16097049
Intra	PPP2R5A	Q15172	PPP2CA	Homo sapiens	P67775	Anti Tag CoIP	33961781
Intra	PPP2R5A	Q15172	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	PPP2R5A	Q15172	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	PPP2R5A	Q15172	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	PPP2R5A	Q15172	PPFIA1	Homo sapiens	Q13136	Y2H Prey Pooling	32296183
Intra	PPP2R5A	Q15172	PPFIA1	Homo sapiens	Q13136	Y2H Array	32296183
Intra	PPP2R5A	Q15172	SGO1	Homo sapiens	Q5FBB7	Protein 3 Hybrid	16541025
Intra	PPP2R5A	Q15172	SGO1	Homo sapiens	Q5FBB7	Anti Bait CoIP	16541025
Intra	PPP2R5A	Q15172	SGO2	Homo sapiens	Q562F6	Anti Tag CoIP	33961781
Intra	PPP2R5A	Q15172	SGO2	Homo sapiens	Q562F6	Y2H	16541025
Intra	PPP2R5A	Q15172	DZIP1	Homo sapiens	Q86YF9	Y2H Prey Pooling	32296183
Intra	PPP2R5A	Q15172	DZIP1	Homo sapiens	Q86YF9	Validated Y2H	32296183
Intra	PPP2R5A	Q15172	DZIP1	Homo sapiens	Q86YF9	Y2H Array	32296183
Intra	PPP2R5A	Q15172	DZIP1	Homo sapiens	Q86YF9	Y2H	21878643

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Progressive Familial Heart Block, Type Ii

PFHB2	Pfhbii
Progressive Familial Heart Block Type Ii	Progressive Familial Heart Block Type 2
Heart Block Progressive Familial Type 2

Cardiomyopathy, Dilated, 1d

Dilated Cardiomyopathy 1d	CMD1D
Left Ventricular Noncompaction 6, Included	Lvnc6, Included
Left Ventricular Noncompaction 6	Cardiomyopathy, Dilated 1d

Cornelia De Lange Syndrome

De Lange Syndrome	Brachmann De Lange Syndrome
Brachmann-De Lange Syndrome	Cdls
Bdls	Typus Degenerativus Amstelodamensis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11018	PPP2R5A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PPP2R5A	VGNC	VGNC:76379
Canis familiaris	PPP2R5A	VGNC	VGNC:44913
Mus musculus	PPP2R5A	MGD	MGI:2388479
Felis catus	PPP2R5A	VGNC	VGNC:69015
Bos taurus	PPP2R5A	VGNC	VGNC:33260
Rattus norvegicus	PPP2R5A	RGD	RGD:1308022
Others	PPP2R5A	NCBI

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