PTPN18 - protein tyrosine phosphatase non-receptor type 18 Gene

Homo sapiens

Also known as BDP1; PTP-HSCF

Gene ID: 26469 | Gene type: protein coding

About PTPN18

Cytogenetic location: 2q21.1 Genomic coordinates (GRCh38): 2:130,356,056-130,375,405 (from NCBI)

This gene has 16 transcripts (splice variants), 73 orthologues and 35 paralogues. Ubiquitous expression in lymph node (RPKM 34.1), spleen (RPKM 27.5) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of Receptor Tyrosine Kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

PTPN18 Products(2)

mRNA	Protein	Name
NM_001142370.2	NP_001135842.1	tyrosine-protein phosphatase non-receptor type 18 isoform 2
NM_014369.4	NP_055184.2	tyrosine-protein phosphatase non-receptor type 18 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	9422760	GOA
enables protein tyrosine phosphatase activity	EXP EXP: Inferred from Experiment	25081058	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPN18 Protein Structure

Y_phosphatase

0
100
200
300
400
460 a.a.

Protein Preferred Names

Protein Names

tyrosine-protein phosphatase non-receptor type 18

brain-derived phosphatase

PTPN18 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PTPN18	Q99952	PSTPIP1	Homo sapiens	O43586	Anti Tag CoIP	9422760
Intra	PTPN18	Q99952	BTRC	Homo sapiens	Q9Y297	Anti Bait CoIP	25081058
Intra	PTPN18	Q99952	ERBB2	Homo sapiens	P04626	Phosphatase Assay	25081058
Intra	PTPN18	Q99952	ERBB2	Homo sapiens	P04626	X-Ray Diffraction	25081058

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Toxic Diffuse Goiter

Erythrocytosis, Familial, 7

ECYT7	Erythrocytosis 7
Familial Erythrocytosis 7	Erythrocytosis, Alpha-Globin Type
Polycythemia, Alpha-Globin Type	Alpha-Globin Type Erythrocytosis
Alpha-Globin Type Polycythemia

Erythrocytosis, Familial, 6

ECYT6	Erythrocytosis 6
Familial Erythrocytosis 6	Erythrocytosis, Beta-Globin Type
Polycythemia, Beta-Globin Type	Beta-Globin Type Erythrocytosis
Beta-Globin Type Polycythemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11420	PTPN18 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PTPN18	MGD	MGI:108410
Macaca mulatta	PTPN18	VGNC	VGNC:76601
Bos taurus	PTPN18	VGNC	VGNC:33533
Rattus norvegicus	PTPN18	RGD	RGD:1311586

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