BTRC - beta-transducin repeat containing E3 ubiquitin protein ligase Gene

Homo sapiens

Also known as FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP

Gene ID: 8945 | Gene type: protein coding

About BTRC

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:101,354,048-101,557,313 (from NCBI)

This gene has 7 transcripts (splice variants), 140 orthologues, 14 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 11.6), testis (RPKM 7.3) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa LIGHT polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]

BTRC Products(3)

mRNA	Protein	Name
NM_001256856.2	NP_001243785.1	F-box/WD repeat-containing protein 1A isoform 3
NM_003939.5	NP_003930.1	F-box/WD repeat-containing protein 1A isoform 2
NM_033637.4	NP_378663.1	F-box/WD repeat-containing protein 1A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-catenin binding	IDA IDA: Inferred from direct assay	12820959	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9859996	GOA
enables ubiquitin ligase activator activity	IDA IDA: Inferred from direct assay	12820959	GOA
enables ubiquitin-like ligase-substrate adaptor activity	IDA IDA: Inferred from direct assay	10066435	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	22017875	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19966869	GOA
involved in negative regulation of T cell receptor signaling pathway	IDA IDA: Inferred from direct assay	38225265	GOA
involved in non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	10066435	GOA
involved in positive regulation of proteolysis	IMP IMP: Inferred from mutant phenotype	16885022	GOA
involved in positive regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	12820959	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15917222	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	38225265	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	16885022	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	12820959	GOA
involved in protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	12820959	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	16885022	GOA
involved in protein ubiquitination	IMP IMP: Inferred from mutant phenotype	21258371	GOA
involved in regulation of circadian rhythm	IDA IDA: Inferred from direct assay	15917222	GOA
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15448698	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	12820959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTRC Protein Structure

Beta-TrCP_D

F-box-like

WD40

0
100
200
300
400
500
605 a.a.

Protein Preferred Names

Protein Names

F-box/WD repeat-containing protein 1A

E3RSIkappaB

Related Diseases

Diseases

Alias

Isolated Split Hand-Split Foot Malformation

Ectrodactyly	Shfm
Split Hand Foot Malformation	Split-Hand/Foot Malformation
Split Hand Foot Deformity 1	Split Hand Foot Deformity

Vaccinia

Adult Liposarcoma

Split-Hand/Foot Malformation 3

SHFM3	Split Hand-Foot Malformation 3
Chromosome 10q24 Duplication Syndrome	Shsf3
Limb Deficiencies, Distal, With Micrognathia	Split-Hand/Foot Malformation 3, Gene Duplication Syndrome
Distal Limb Deficiencies With Micrognathia	Limb Deficiencies Distal With Micrognathia
Buttiens Fryns Syndrome	Distal Limb Deficiencies-Micrognathia Syndrome
10q24 Microduplication Syndrome	Buttiens-Fryns Syndrome
Split-Hand/Foot Malformation, Type 3, Gene Duplication Syndrome

Split Hand-Foot Malformation

Ectrodactyly	Split-Hand/Foot Malformation
Lobster-Claw Deformity	Split-Hand Deformity
Split Hand Foot Malformation	Shfm
Split Hand Foot Deformity	Split Hand Foot Deformity 1

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Erythrocytosis, Familial, 1

ECYT1	Pfcp
Primary Familial And Congenital Polycythemia	Familial Erythrocytosis 1
Familial Erythrocytosis	Polycythemia, Primary Familial And Congenital
Autosomal Dominant Benign Erythrocytosis	Familial Erythrocytosis Type 1
Congenital Erythrocytosis Due To Erythropoietin Receptor Mutation	Congenital Polycythemia Due To Erythropoietin Receptor Mutation
Primary Congenital Erythrocytosis	Primary Familial Polycythemia
Erythrocytosis, Autosomal Dominant Benign	Erythrocytosis, Somatic
Autosomal Dominant Familial Erythrocytosis-1	Erythrocytosis Autosomal Dominant Benign
Familial Primary Polycythemia	Familial Erythrocytosis, 1
Erythrocytosis, Familial, Type 1

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01680	BTRC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BTRC	RGD	RGD:1359721
Mus musculus	BTRC	MGD	MGI:1338871
Canis familiaris	BTRC	VGNC	VGNC:38564
Macaca mulatta	BTRC	VGNC	VGNC:100303
Bos taurus	BTRC	VGNC	VGNC:26603

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