2. Gene
  3. BTRC - beta-transducin repeat containing E3 ubiquitin protein ligase Gene

BTRC - beta-transducin repeat containing E3 ubiquitin protein ligase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FWD1; FBW1A; FBXW1; bTrCP; FBXW1A; bTrCP1; betaTrCP; BETA-TRCP

Gene ID: 8945 | Gene type: protein coding

About BTRC

Cytogenetic location: 10q24.32 Genomic coordinates (GRCh38): 10:101,354,048-101,557,313 (from NCBI)

This gene has 7 transcripts (splice variants), 140 orthologues, 14 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 11.6), testis (RPKM 7.3) and 25 other tissues.

Summary

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein Ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar 2012]

BTRC Products(3)

mRNA Protein Name
NM_001256856.2 NP_001243785.1 F-box/WD repeat-containing protein 1A isoform 3
NM_003939.5 NP_003930.1 F-box/WD repeat-containing protein 1A isoform 2
NM_033637.4 NP_378663.1 F-box/WD repeat-containing protein 1A isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables beta-catenin binding IDA
IDA: Inferred from direct assay
12820959 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9859996 GOA
enables ubiquitin ligase activator activity IDA
IDA: Inferred from direct assay
12820959 GOA
enables ubiquitin-like ligase-substrate adaptor activity IDA
IDA: Inferred from direct assay
10066435 GOA
Biological Process GO Annotation Evidence Reference Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
22017875 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
19966869 GOA
involved in negative regulation of T cell receptor signaling pathway IDA
IDA: Inferred from direct assay
38225265 GOA
involved in non-canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
10066435 GOA
involved in positive regulation of proteolysis IMP
IMP: Inferred from mutant phenotype
16885022 GOA
involved in positive regulation of ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
12820959 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
15917222 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
38225265 GOA
involved in protein destabilization IMP
IMP: Inferred from mutant phenotype
16885022 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
12820959 GOA
involved in protein polyubiquitination IMP
IMP: Inferred from mutant phenotype
12820959 GOA
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
16885022 GOA
involved in protein ubiquitination IMP
IMP: Inferred from mutant phenotype
21258371 GOA
involved in regulation of circadian rhythm IDA
IDA: Inferred from direct assay
15917222 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
15448698 GOA
Cellular Component GO Annotation Evidence Reference Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
12820959 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BTRC Protein Structure

Beta-TrCP_D

Beta-TrCP_D: D domain of beta-TrCP (138 - 177)

F-box-like

F-box-like: F-box-like (191 - 228)

WD40

WD40: WD domain, G-beta repeat (304 - 329)

WD40

WD40: WD domain, G-beta repeat (334 - 369)

WD40

WD40: WD domain, G-beta repeat (374 - 409)

WD40

WD40: WD domain, G-beta repeat (420 - 452)

WD40

WD40: WD domain, G-beta repeat (457 - 492)

WD40

WD40: WD domain, G-beta repeat (497 - 532)

WD40

WD40: WD domain, G-beta repeat (547 - 581)

  • 0
  • 100
  • 200
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  • 400
  • 500
  • 605 a.a.
Protein Preferred Names Protein Names

F-box/WD repeat-containing protein 1A

E3RSIkappaB

BTRC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
BTRC Q9Y297 IL10RA Homo sapiens Q13651
Y2H Prey Pooling
32296183
Intra
BTRC Q9Y297 IL10RA Homo sapiens Q13651
Y2H Array
32296183
Intra
BTRC Q9Y297 YAP1 Homo sapiens P46937
Y2H
21900206
Intra
BTRC Q9Y297 YAP1 Homo sapiens P46937
Anti Tag CoIP
33961781
Intra
BTRC Q9Y297 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
BTRC Q9Y297 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
BTRC Q9Y297 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Intra
BTRC Q9Y297 TACC1 Homo sapiens O75410-7
Validated Y2H
26871637
Intra
BTRC Q9Y297 TACC1 Homo sapiens O75410-7
Y2H Array
26871637
Intra
BTRC Q9Y297 TACC1 Homo sapiens O75410-7
Y2H Array
32296183
Intra
BTRC Q9Y297 TACC1 Homo sapiens O75410-7
Y2H Prey Pooling
26871637
Intra
BTRC Q9Y297 TACC1 Homo sapiens O75410-7
Y2H Prey Pooling
32296183
Intra
BTRC Q9Y297 TRIM9 Homo sapiens Q9C026-5
Y2H Array
31515488
Intra
BTRC Q9Y297 TRIM9 Homo sapiens Q9C026-5
Validated Y2H
26871637
Intra
BTRC Q9Y297 TRIM9 Homo sapiens Q9C026-5
Y2H Prey Pooling
26871637
Intra
BTRC Q9Y297 TRIM9 Homo sapiens Q9C026-5
Y2H Array
26871637
Intra
BTRC Q9Y297 SKP1 Homo sapiens P63208
Lumier
37398436
Intra
BTRC Q9Y297 SKP1 Homo sapiens P63208
CoIP
10644755
Intra
BTRC Q9Y297 SKP1 Homo sapiens P63208
Anti Tag CoIP
15070733
Intra
BTRC Q9Y297 SKP1 Homo sapiens P63208
Anti Tag CoIP
22632967
Intra
BTRC Q9Y297 SKP1 Homo sapiens P63208
Pull Down
9660940
Intra
BTRC Q9Y297 SKP1 Homo sapiens P63208
BRET
37398436
Intra
BTRC Q9Y297 SKP1 Homo sapiens P63208
CoIP
12609982
Intra
BTRC Q9Y297 SKP1 Homo sapiens P63208
Anti Tag CoIP
33961781
Intra
BTRC Q9Y297 SKP1 Homo sapiens P63208
MAPPIT
19159283
Intra
BTRC Q9Y297 DLG1 Homo sapiens Q12959
Anti Bait CoIP
12902344
Intra
BTRC Q9Y297 CUL1 Homo sapiens Q13616
CoIP
12609982
Intra
BTRC Q9Y297 CUL1 Homo sapiens Q13616
Anti Tag CoIP
19615732
Intra
BTRC Q9Y297 CUL1 Homo sapiens Q13616
CoIP
10644755
Intra
BTRC Q9Y297 CUL1 Homo sapiens Q13616
Anti Tag CoIP
21145461
Intra
BTRC Q9Y297 CUL1 Homo sapiens Q13616
Anti Tag CoIP
33961781
Intra
BTRC Q9Y297 CUL1 Homo sapiens Q13616
Anti Tag CoIP
18354482
Intra
BTRC Q9Y297 TP53 Homo sapiens P04637
Anti Tag CoIP
19196987
Intra
BTRC Q9Y297 RASSF5 Homo sapiens Q8WWW0
Validated Y2H
25416956
Intra
BTRC Q9Y297 RASSF5 Homo sapiens Q8WWW0
Y2H Prey Pooling
25416956
Intra
BTRC Q9Y297 RASSF5 Homo sapiens Q8WWW0
Y2H Array
25416956
Intra
BTRC Q9Y297 MDM2 Homo sapiens Q00987
Pull Down
20708156
Intra
BTRC Q9Y297 MDM2 Homo sapiens Q00987
Anti Tag CoIP
20708156
Intra
BTRC Q9Y297 AXIN2 Homo sapiens Q9Y2T1
Y2H Array
32296183
Intra
BTRC Q9Y297 AXIN2 Homo sapiens Q9Y2T1
Y2H Prey Pooling
32296183
Intra
BTRC Q9Y297 AXIN2 Homo sapiens Q9Y2T1
Validated Y2H
32296183
Intra
BTRC Q9Y297 COPS6 Homo sapiens Q7L5N1
Anti Bait CoIP
26267535
Intra
BTRC Q9Y297 CTNNB1 Homo sapiens P35222
Anti Bait CoIP
20531388
Intra
BTRC Q9Y297 CTNNB1 Homo sapiens P35222
Anti Tag CoIP
16376880
Intra
BTRC Q9Y297 CTNNB1 Homo sapiens P35222
Anti Tag CoIP
20531388
Intra
BTRC Q9Y297 ATF4 Homo sapiens P18848
Y2H Array
21988832
Intra
BTRC Q9Y297 ATF4 Homo sapiens P18848
Confocal
21988832
Intra
BTRC Q9Y297 ATF4 Homo sapiens P18848
Y2H
21988832
Intra
BTRC Q9Y297 ATF4 Homo sapiens P18848
Y2H Array
31515488
Intra
BTRC Q9Y297 ATF4 Homo sapiens P18848
Y2H Prey Pooling
26871637
Intra
BTRC Q9Y297 ATF4 Homo sapiens P18848
Validated Y2H
25416956
Intra
BTRC Q9Y297 ATF4 Homo sapiens P18848
Y2H Prey Pooling
32296183
Intra
BTRC Q9Y297 ATF4 Homo sapiens P18848
Validated Y2H
26871637
Intra
BTRC Q9Y297 ATF4 Homo sapiens P18848
Y2H Array
25416956
Intra
BTRC Q9Y297 ATF4 Homo sapiens P18848
Y2H Array
26871637
Intra
BTRC Q9Y297 ATF4 Homo sapiens P18848
Y2H Array
32296183
Intra
BTRC Q9Y297 ATF4 Homo sapiens P18848
Y2H Array
29892012
Intra
BTRC Q9Y297 MAP2K1 Homo sapiens Q02750
Anti Tag CoIP
24211253
Intra
BTRC Q9Y297 AMER1 Homo sapiens Q5JTC6
Anti Tag CoIP
33961781
Intra
BTRC Q9Y297 TACC1 Homo sapiens O75410
Y2H Prey Pooling
25416956
Intra
BTRC Q9Y297 TACC1 Homo sapiens O75410
Validated Y2H
25416956
Intra
BTRC Q9Y297 TACC1 Homo sapiens O75410
Y2H Array
25416956
Intra
BTRC Q9Y297 NEDD8 Homo sapiens Q15843
Anti Bait CoIP
17318178
Intra
BTRC Q9Y297 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
BTRC Q9Y297 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
BTRC Q9Y297 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
BTRC Q9Y297 TRIM9 Homo sapiens Q9C026
Validated Y2H
25416956
Intra
BTRC Q9Y297 TRIM9 Homo sapiens Q9C026
Y2H Prey Pooling
32296183
Intra
BTRC Q9Y297 TRIM9 Homo sapiens Q9C026
Y2H Array
25416956
Intra
BTRC Q9Y297 TRIM9 Homo sapiens Q9C026
Anti Tag CoIP
33961781
Intra
BTRC Q9Y297 TRIM9 Homo sapiens Q9C026
Y2H Array
32296183
Intra
BTRC Q9Y297 TRIM9 Homo sapiens Q9C026
Y2H Pooling
16189514
Intra
BTRC Q9Y297 NFE2 Homo sapiens Q16621
Y2H Array
25416956
Intra
BTRC Q9Y297 PLK4 Homo sapiens O00444
Y2H Prey Pooling
26871637
Intra
BTRC Q9Y297 PLK4 Homo sapiens O00444
Y2H Array
26871637
Intra
BTRC Q9Y297 PLK4 Homo sapiens O00444
Anti Tag CoIP
25503564
Intra
BTRC Q9Y297 PLK4 Homo sapiens O00444
Validated Y2H
26871637
Intra
BTRC Q9Y297 WWTR1 Homo sapiens Q9GZV5
Anti Bait CoIP
22078877
Intra
BTRC Q9Y297 ZC3H12A Homo sapiens Q5D1E8
Y2H
21988832
Intra
BTRC Q9Y297 NDUFV1 Homo sapiens P49821
Y2H Array
32814053
Intra
BTRC Q9Y297 NDUFV1 Homo sapiens P49821
Y2H Pooling
32814053
Intra
BTRC Q9Y297 NDUFV1 Homo sapiens P49821
Validated Y2H
32814053
Intra
BTRC Q9Y297 INAVA Homo sapiens Q3KP66
Anti Tag CoIP
29420262
Intra
BTRC Q9Y297 WEE1 Homo sapiens P30291
Anti Tag CoIP
15070733
Intra
BTRC Q9Y297 REST Homo sapiens Q13127
Anti Tag CoIP
18354482
Intra
BTRC Q9Y297 RASSF5 Homo sapiens Q8WWW0-2
Y2H Prey Pooling
26871637
Intra
BTRC Q9Y297 RASSF5 Homo sapiens Q8WWW0-2
Validated Y2H
26871637
Intra
BTRC Q9Y297 RASSF5 Homo sapiens Q8WWW0-2
Y2H Array
26871637
Cross
BTRC Q9Y297 Dlg1 Rattus norvegicus Q62696
Anti Tag CoIP
12902344
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Isolated Split Hand-Split Foot Malformation

Ectrodactyly

Shfm

Split Hand Foot Malformation

Split-Hand/Foot Malformation

Split Hand Foot Deformity 1

Split Hand Foot Deformity
Vaccinia
Adult Liposarcoma
Split-Hand/Foot Malformation 3

SHFM3

Split Hand-Foot Malformation 3

Chromosome 10q24 Duplication Syndrome

Shsf3

Limb Deficiencies, Distal, With Micrognathia

Split-Hand/Foot Malformation 3, Gene Duplication Syndrome

Distal Limb Deficiencies With Micrognathia

Limb Deficiencies Distal With Micrognathia

Buttiens Fryns Syndrome

Distal Limb Deficiencies-Micrognathia Syndrome

10q24 Microduplication Syndrome

Buttiens-Fryns Syndrome

Split-Hand/Foot Malformation, Type 3, Gene Duplication Syndrome
Split Hand-Foot Malformation

Ectrodactyly

Split-Hand/Foot Malformation

Lobster-Claw Deformity

Split-Hand Deformity

Split Hand Foot Malformation

Shfm

Split Hand Foot Deformity

Split Hand Foot Deformity 1
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
Erythrocytosis, Familial, 1

ECYT1

Pfcp

Primary Familial And Congenital Polycythemia

Familial Erythrocytosis 1

Familial Erythrocytosis

Polycythemia, Primary Familial And Congenital

Autosomal Dominant Benign Erythrocytosis

Familial Erythrocytosis Type 1

Congenital Erythrocytosis Due To Erythropoietin Receptor Mutation

Congenital Polycythemia Due To Erythropoietin Receptor Mutation

Primary Congenital Erythrocytosis

Primary Familial Polycythemia

Erythrocytosis, Autosomal Dominant Benign

Erythrocytosis, Somatic

Autosomal Dominant Familial Erythrocytosis-1

Erythrocytosis Autosomal Dominant Benign

Familial Primary Polycythemia

Familial Erythrocytosis, 1

Erythrocytosis, Familial, Type 1
Gastric Cancer

Stomach Cancer

Gastric Carcinoma

Stomach Carcinoma

Gastric Cancer, Somatic

Gastric Neoplasm

Carcinoma Of Stomach

Stomach Neoplasms

Malignant Neoplasm Of Stomach

Gastric Cancer Risk After H. Pylori Infection

Cancer Of The Stomach

Adult Stomach Cancer

Adult Stomach Carcinoma

GASC

Gastric Cancer Intestinal

Gastric Cancers

Gastric Carcinomas

Cancer, Gastric

Stomach Neoplasm

Malignant Neoplasm Of Body Of Stomach

Malignant Tumor Of Lesser Curve Of Stomach

Gastrocarcinoma Of Unspecified Site

Leather Bottle Stomach

Carcinoma Of Fundus Of Stomach

Cancer Of Fundus Of Stomach

Primary Malignant Neoplasm Of Body Of Stomach

Cancer Of Body Of Stomach

Primary Malignant Neoplasm Of Pyloric Antrum

Pyloric Antrum Cancer

Malignant Tumour Of Stomach
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01680 BTRC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus BTRC RGD RGD:1359721
Mus musculus BTRC MGD MGI:1338871
Canis familiaris BTRC VGNC VGNC:38564
Macaca mulatta BTRC VGNC VGNC:100303
Bos taurus BTRC VGNC VGNC:26603