OSTF1 - osteoclast stimulating factor 1 Gene

Homo sapiens

Also known as OSF; SH3P2; bA235O14.1

Gene ID: 26578 | Gene type: protein coding

About OSTF1

Cytogenetic location: 9q21.13 Genomic coordinates (GRCh38): 9:75,088,514-75,147,265 (from NCBI)

This gene has 1 transcript (splice variant) and 217 orthologues. Ubiquitous expression in spleen (RPKM 44.5), esophagus (RPKM 43.2) and 25 other tissues.

Summary

Osteoclast-stimulating factor-1 is an intracellular protein produced by osteoclasts that indirectly induces osteoclast formation and bone resorption (Reddy et al., 1998 [PubMed 10092216]).[supplied by OMIM, Mar 2008]

OSTF1 Products(1)

mRNA	Protein	Name
NM_012383.5	NP_036515.4	osteoclast-stimulating factor 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSTF1 Protein Structure

SH3_1

Ank_2

0
100
200
214 a.a.

Protein Preferred Names

Protein Names

osteoclast-stimulating factor 1

OSTF1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OSTF1	Q92882	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
Intra	OSTF1	Q92882	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
Intra	OSTF1	Q92882	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	OSTF1	Q92882	HTT	Homo sapiens	P42858	Y2H	17500595

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Narcissistic Personality Disorder

Epithelial-Stromal Tgfbi Dystrophy

Paraphilia Disorder

Paraphilia

Paraphilias

Exhibitionism

Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V

Yaws

Frambesia	Frambesia Tropica
Bouba	Frambosie
Polypapilloma Tropicum	Thymosis
Endemic Treponematoses	Treponema Pertenue Infection
Pian	Framboesia
Framboesia Tropica	Castellani
Infection By Treponema Pertenue	Parangi
Framboesioma	Chancre Of Yaws
Primary Framboesia	Initial Lesions Of Yaws
Mother Yaw	Initial Framboesia

Multiple Personality Disorder

Dissociative Identity Disorder

Multiple Personality

Alexithymia

Speech And Communication Disorders

Language Disorder	Communication Disorder
Language Disorders	Communication Disorders
Speech Language Disorder	Speech-Language Disorder
Communication Impairment	Speech And Language Disorder

Stork Bite

Salmon Patch Nevus

Unna'S Nevus

Dissociative Disorder

Dissociative Disorders	Dissociative Disease
Dissociative Reaction

Developmental Coordination Disorder

Motor Skills Disorders

Pedophilia

Paedophilia

Generalized Anxiety Disorder

Anxiety Generalized

Prosopagnosia

Separation Anxiety Disorder

Separation Anxiety Disorder Of Childhood

Phobia, Specific

Specific Phobia	Simple Phobia
Phobia, Simple	Isolated Phobia

Reading Disorder

Specific Reading Disorder	Reading
Dyslexia	Developmental Reading Disorder

Phobic Disorder

Phobic Disorders

Phobic Anxiety Disorder

Oppositional Defiant Disorder

Disorder	Oppositional Defiance
Behavioural Disorder	Oppositional Defiance
Disruptive Mood Dysregulation Disorder

Learning Disability

Learning Disabilities	Learning Disorders
Academic Skill Disorder	Learning Disorder

Specific Language Impairment

Language Impairment, Specific

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Dyslexia

Attention Deficit-Hyperactivity Disorder

Attention Deficit Hyperactivity Disorder	ADHD
Attention Deficit Disorder	Attention Deficit-Hyperactivity Disorder, Susceptibility To
Attention Deficit Disorder With Hyperactivity	Hyperkinetic Disorder
Hyperactivity Of Childhood	Attention-Deficit/Hyperactivity Disorder
Add	Addh
Attention Deficit	Attention Deficit Disorder Of Childhood With Hyperactivity
Attention Deficit Disorder With Hyperactivity Syndrome	Hyperkinetic Syndrome
Attention-Deficit Hyperactivity Disorder	Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type
Disturbance Of Activity And Attention	Disorder Of Activity And Attention
Adhd - [Attention Deficit Hyperactivity Disorder]	Hyperkinetic Disorders
Disorder Of Activity And Attention With Hyperkinesia	Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09856	OSTF1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	OSTF1	VGNC	VGNC:44171
Mus musculus	OSTF1	MGD	MGI:700012
Felis catus	OSTF1	VGNC	VGNC:102960
Macaca mulatta	OSTF1	VGNC	VGNC:75722
Rattus norvegicus	OSTF1	RGD	RGD:628849
Bos taurus	OSTF1	VGNC	VGNC:32479

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