AMFR - autocrine motility factor receptor Gene

Homo sapiens

Also known as GP78; RNF45

Gene ID: 267 | Gene type: protein coding

About AMFR

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,361,452-56,425,545 (from NCBI)

This gene has 12 transcripts (splice variants), 233 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 45.4), kidney (RPKM 36.4) and 25 other tissues.

Summary

This locus encodes a glycosylated transmembrane receptor. Its ligand, autocrine motility factor, is a tumor motility-stimulating protein secreted by tumor cells. The encoded receptor is also a member of the E3 ubiquitin Ligase family of proteins. It catalyzes ubiquitination and endoplasmic reticulum-associated degradation of specific proteins. [provided by RefSeq, Feb 2012]

AMFR Products(3)

mRNA	Protein	Name
NM_001144.6	NP_001135.3	E3 ubiquitin-protein ligase AMFR isoform c
NM_001323511.2	NP_001310440.1	E3 ubiquitin-protein ligase AMFR isoform e
NM_001323512.2	NP_001310441.1	E3 ubiquitin-protein ligase AMFR isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables BAT3 complex binding	IDA IDA: Inferred from direct assay	24424410	GOA
enables BAT3 complex binding	IPI IPI: Inferred from physical interaction	21636303	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	17310145	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11724934	GOA
enables protein-folding chaperone binding	IPI IPI: Inferred from physical interaction	21636303	GOA
enables protein-macromolecule adaptor activity	IMP IMP: Inferred from mutant phenotype	24424410	GOA
enables signaling receptor activity	IPI IPI: Inferred from physical interaction	1649192	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	17310145	GOA
enables ubiquitin protein ligase activity	IMP IMP: Inferred from mutant phenotype	37119330	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	11724934	GOA
enables ubiquitin-protein transferase activity	IMP IMP: Inferred from mutant phenotype	16168377	GOA
enables ubiquitin-specific protease binding	IPI IPI: Inferred from physical interaction	24424410	GOA
enables ubiquitin-ubiquitin ligase activity	IDA IDA: Inferred from direct assay	24810856	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ERAD pathway	IDA IDA: Inferred from direct assay	11724934	GOA
involved in ERAD pathway	IMP IMP: Inferred from mutant phenotype	16168377	GOA
involved in endoplasmic reticulum unfolded protein response	IMP IMP: Inferred from mutant phenotype	17157811	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	31073040	GOA
involved in non-canonical NF-kappaB signal transduction	IDA IDA: Inferred from direct assay	15327770	GOA
involved in protein K27-linked ubiquitination	IDA IDA: Inferred from direct assay	15327770	GOA
involved in protein K48-linked ubiquitination	IDA IDA: Inferred from direct assay	12847084	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	24810856	GOA
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	17310145	GOA
involved in protein polyubiquitination	IMP IMP: Inferred from mutant phenotype	24810856	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	16168377	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Derlin-1 retrotranslocation complex	IDA IDA: Inferred from direct assay	17872946	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	22728137	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	11724934	GOA
located in endoplasmic reticulum membrane	IMP IMP: Inferred from mutant phenotype	37119330	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16275660	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	23382219	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMFR Protein Structure

zf-RING_2

CUE

0
100
200
300
400
500
600
643 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase AMFR

RING finger protein 45

AMFR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AMFR	Q9UKV5	UBE2G2	Homo sapiens	P60604	NMR	23942235
Intra	AMFR	Q9UKV5	VCP	Homo sapiens	P55072	Pull Down	16275660
Intra	AMFR	Q9UKV5	VCP	Homo sapiens	P55072	Anti Bait CoIP	16407162
Intra	AMFR	Q9UKV5	VCP	Homo sapiens	P55072	Pull Down	22119785
Intra	AMFR	Q9UKV5	UBE2G2	Homo sapiens	P60604	Pull Down	22119785
Intra	AMFR	Q9UKV5	VCP	Homo sapiens	P55072	Anti Bait CoIP	21343306
Intra	AMFR	Q9UKV5	UBE2G2	Homo sapiens	P60604	Anti Tag CoIP	16407162
Intra	AMFR	Q9UKV5	VCP	Homo sapiens	P55072	Anti Tag CoIP	16275660
Intra	AMFR	Q9UKV5	UBE2G2	Homo sapiens	P60604	Anti Bait CoIP	17353931
Intra	AMFR	Q9UKV5	UBE2G2	Homo sapiens	P60604	SAXS	23942235
Intra	AMFR	Q9UKV5	TMUB1	Homo sapiens	Q9BVT8	Pull Down	22119785
Intra	AMFR	Q9UKV5	ERLIN1	Homo sapiens	O75477	Pull Down	22119785
Intra	AMFR	Q9UKV5	ERLIN1	Homo sapiens	O75477	Anti Tag CoIP	21343306
Intra	AMFR	Q9UKV5	ERLIN2	Homo sapiens	O94905	Pull Down	22119785
Intra	AMFR	Q9UKV5	ERLIN2	Homo sapiens	O94905	Anti Tag CoIP	21343306
Intra	AMFR	Q9UKV5	ERLIN2	Homo sapiens	O94905	Anti Bait CoIP	21343306
Cross	AMFR	Q9UKV5	Ube2g2	Mus musculus	P60605	X-Ray Diffraction	19223579
Cross	AMFR	Q9UKV5	Ube2g2	Mus musculus	P60605	Pull Down	16462746
Cross	AMFR	Q9UKV5	Ube2g2	Mus musculus	P60605	Anti Tag CoIP	16407162
Cross	AMFR	Q9UKV5	Ube2g2	Mus musculus	P60605	GMS	19223579
Cross	AMFR	Q9UKV5	Ube2g2	Mus musculus	P60605	Pull Down	19223579

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Encephalopathy, Familial, With Neuroserpin Inclusion Bodies

Familial Encephalopathy With Neuroserpin Inclusion Bodies	FENIB
Encephalopathy, Familial, With Collins Bodies	Familial Dementia With Neuroserpin Inclusion Bodies
Familial Encephalopathy With Collins Bodies

Transitional Cell Carcinoma

Transitional Cell Neoplasm	Carcinoma, Transitional Cell
Transitional Carcinoma	Transitional Cell Tumor
Urothelial Cell Carcinoma	Carcinoma Transitional Cell
Transitional Cell Carcinoma Of Bladder

Hepatocellular Clear Cell Carcinoma

Clear Cell Carcinoma Of The Liver Cells	Hepatocellular Carcinoma, Clear Cell Type
Clear Cell Hepatocellular Carcinoma

Spastic Paraplegia, Optic Atrophy, And Neuropathy

Spoan Syndrome	SPOAN
Spastic Paraplegia, Optic Atropy, And Neuropathy	Spastic Paraplegia, Optic Atropy, And Neuropathy Syndrome
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia

Ibmpfd	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dementia
Pagetoid Amyotrophic Lateral Sclerosis	Pagetoid Neuroskeletal Syndrome
Inclusion Body Myopathy With Paget Disease Of Bone And/Or Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone And/Or Frontotemporal Dementia
Multisystem Proteinopathy	Limb-Girdle Muscular Dystrophy With Paget Disease Of Bone
Inclusion Body Myopathy With Paget'S Disease Of Bone And Frontotemporal Dementia	Inclusion Body Myopathy With Early-Onset Paget Disease And Frontotemporal Dement
Lower Motor Neuron Degeneration With Paget-Like Bone Disease	Muscular Dystrophy, Limb-Girdle, With Paget Disease Of Bone
Myopathy, Inclusion Body, With Early-Onset Paget Disease And Frontotemporal Dementia

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00652	AMFR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AMFR	RGD	RGD:1311551
Bos taurus	AMFR	VGNC	VGNC:25863
Mus musculus	AMFR	MGD	MGI:1345634
Macaca mulatta	AMFR	VGNC	VGNC:69804
Canis familiaris	AMFR	VGNC	VGNC:37829
Felis catus	AMFR	VGNC	VGNC:67490

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