2. Gene
  3. Map4k4 - mitogen-activated protein kinase kinase kinase kinase 4 Gene

Map4k4 - mitogen-activated protein kinase kinase kinase kinase 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as HGK; Nik; 9430080K19Rik

Gene ID: 26921 | Gene type: protein coding

About Map4k4

Chromosome 1: 39,940,073-40,065,470 forward strand.GRCm39:CM000994.3

This gene has 18 transcripts (splice variants), 281 orthologues, 35 paralogues and is associated with 6 phenotypes. Broad expression in CNS E14 (RPKM 64.6), CNS E11.5 (RPKM 64.4) and 27 other tissues.

Summary

Enables ATP binding activity and protein serine/threonine kinase activity. Involved in several processes, including positive regulation of cell-substrate junction organization; positive regulation of intracellular signal transduction; and positive regulation of keratinocyte migration. Located in focal adhesion. Is expressed in several structures, including genitourinary system; molar; nervous system; neural retina; and skin. Orthologous to human MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Map4k4 Products(4)

mRNA Protein Name
NM_001252201.1 NP_001239130.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 3
NM_008696.2 NP_032722.2 mitogen-activated protein kinase kinase kinase kinase 4 isoform 2
NM_001252200.1 NP_001239129.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 1
NM_001252202.1 NP_001239131.1 mitogen-activated protein kinase kinase kinase kinase 4 isoform 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables ATP binding IDA
IDA: Inferred from direct assay
9135144 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16938849 MGI
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
9135144 MGI
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of ARF protein signal transduction IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of JNK cascade IDA
IDA: Inferred from direct assay
9135144 MGI
involved in positive regulation of focal adhesion assembly IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of focal adhesion disassembly IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in positive regulation of keratinocyte migration IMP
IMP: Inferred from mutant phenotype
25490267 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9135144 MGI
Cellular Component GO Annotation Evidence Reference Source
located in focal adhesion IDA
IDA: Inferred from direct assay
25490267 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Map4k4 Protein Structure

PKc_like

PKc_like: cl21453 (7 - 288)

CNH

CNH: smart00036 (969 - 1267)

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  • 1288 a.a.
Protein Preferred Names Protein Names

mitogen-activated protein kinase kinase kinase kinase 4

HPK/GCK-like kinase HGK

MAPK/ERK kinase kinase kinase 4

MEK kinase kinase 4

MEKKK 4

NCK interacting kinase

nck-interacting kinase

Related Agents

Pre-clinical Phase
Bioactive Molecules (14)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100343 GNE-495 Inhibitor 99.40% Unkown
HY-111754 DMX-5804 Inhibitor 99.83% Unkown
HY-19562 PF-06260933 Inhibitor 99.67% Unkown
HY-125012 MAP4K4-IN-3 Inhibitor 99.15% Unkown
HY-132290 TGFβRI-IN-3 Inhibitor 98.21% Unkown
HY-U00428A GNE 220 hydrochloride Inhibitor 98.22% Unkown
HY-160623 INS018 055 Inhibitor 99.38% Unkown
HY-U00428 GNE 220 Inhibitor / Unkown
HY-156523 TNIK&MAP4K4-IN-1 / Unkown
HY-162922 MAP4K4-IN-6 Inhibitor / Unkown
HY-RS08080 MAP4K4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08081 Map4k4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS08082 Map4k4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-19562A PF-06260933 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map4k4 NCBI NCBI:9448