2. MAPK/ERK Pathway
  3. MAP4K
  4. INS018 055

INS018 055  (Synonyms: TNIK&MAP4K4-IN-2)

Cat. No.: HY-160623 Purity: 99.38% ee.: =
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INS018 055 (compound 112) is a TNIK and MAP4K4 inhibitor with IC50 values of 12-120, 12-120 nM, respectively.

For research use only. We do not sell to patients.

INS018 055 Chemical Structure

INS018 055 Chemical Structure

CAS No. : 2828567-39-9

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5 mg USD 320 In-stock
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Based on 1 publication(s) in Google Scholar

INS018 055 Related Antibodies

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MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

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Description

INS018 055 (compound 112) is a TNIK and MAP4K4 inhibitor with IC50 values of 12-120, 12-120 nM, respectively[1].

IC50 & Target[1]

MAP4K4

12-120 nM (IC50)

TNIK

12-120 nM (IC50)

Molecular Weight

487.57

Formula

C27H30FN7O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN=C(C2=C(C3=CC=C(C=C3)F)N=CN2C(C)C)N1)NC4=CC=C(N5CCN(CC5)C)C=C4
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 120 mg/mL (246.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0510 mL 10.2549 mL 20.5099 mL
5 mM 0.4102 mL 2.0510 mL 4.1020 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0510 mL 10.2549 mL 20.5099 mL 51.2747 mL
5 mM 0.4102 mL 2.0510 mL 4.1020 mL 10.2549 mL
10 mM 0.2051 mL 1.0255 mL 2.0510 mL 5.1275 mL
15 mM 0.1367 mL 0.6837 mL 1.3673 mL 3.4183 mL
20 mM 0.1025 mL 0.5127 mL 1.0255 mL 2.5637 mL
25 mM 0.0820 mL 0.4102 mL 0.8204 mL 2.0510 mL
30 mM 0.0684 mL 0.3418 mL 0.6837 mL 1.7092 mL
40 mM 0.0513 mL 0.2564 mL 0.5127 mL 1.2819 mL
50 mM 0.0410 mL 0.2051 mL 0.4102 mL 1.0255 mL
60 mM 0.0342 mL 0.1709 mL 0.3418 mL 0.8546 mL
80 mM 0.0256 mL 0.1282 mL 0.2564 mL 0.6409 mL
100 mM 0.0205 mL 0.1025 mL 0.2051 mL 0.5127 mL
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INS018 055 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

INS018 0552828567-39-9TNIK&MAP4K4-IN-2MAP4KMAPK Kinase Kinase KinaseInhibitorinhibitorinhibit

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