CBLIF - cobalamin binding intrinsic factor Gene

Homo sapiens

Also known as IF; GIF; INF; IFMH; TCN3

Gene ID: 2694 | Gene type: protein coding

About CBLIF

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,829,273-59,845,499 (from NCBI)

This gene has 5 transcripts (splice variants), 131 orthologues, 2 paralogues and is associated with 2 phenotypes. Restricted expression toward stomach (RPKM 444.5).

Summary

This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008]

CBLIF Products(1)

mRNA	Protein	Name
NM_005142.3	NP_005133.2	cobalamin binding intrinsic factor precursor

CBLIF Protein Structure

Cobalamin_bind

0
100
200
300
417 a.a.

Protein Preferred Names

Protein Names

cobalamin binding intrinsic factor

gastric intrinsic factor (vitamin B synthesis)

Recombinant CBLIF Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73859	Intrinsic Factor/GIF Protein, Human (HEK293, His)	P27352-1 (S19-Y417)	≥95%
HY-P700085AF	Animal-Free Intrinsic Factor/GIF Protein, Human (His)	P27352 (M1-Y417)	≥95%

Related Diseases

Diseases

Alias

Intrinsic Factor Deficiency

IFD	Pernicious Anemia, Congenital, Due To Defect Of Intrinsic Factor
Congenital Intrinsic Factor Deficiency	Congenital Pernicious Anemia Due To Defect Of Intrinsic Factor
Intrinsic Factor, Congenital Deficiency Of	Hereditary Intrinsic Factor Deficiency
Congenital Pernicious Anemia	Congenital Deficiency Of Intrinsic Factor
Megaloblastic Anemia Due To Inborn Errors Of Metabolism

Congenital Intrinsic Factor Deficiency

Hereditary Intrinsic Factor Deficiency	Intrinsic Factor Deficiency
Congenital Pernicious Anemia	Gastric Intrinsic Factor Deficiency
Hereditary Juvenile Megaloblastic Anemia Due To Intrinsic Factor Deficiency	Ifd
Intrinsic Factor Deficiency, Congenital, Susceptibility To	Congenital Deficiency Of Intrinsic Factor
Megaloblastic Anemia Due To Inborn Errors Of Metabolism

Pernicious Anemia

Anemia, Pernicious	Anemia Pernicious
Pernicious Anaemia	Addison'S Anaemia
Biermer'S Anaemia	Biermer'S Anemia
Acquired Pernicious Anemia	Addison-Biermer Anemia
Addisonian Anemia	Biermer Anemia
Biermer'S Disease	Juvenile Onset Pernicious Anemia
Biermer Disease	Biermer-Addison Disease

Megaloblastic Anemia

Imerslund-Grasbeck Syndrome	Igs
Defect Of Enterocyte Intrinsic Factor Receptor	Enterocyte Cobalamin Malabsorption
Familial Megaloblastic Anemia	Megaloblastic Anemia 1
Selective Cobalamin Malabsorption With Proteinuria	Imerslund-Gräsbeck Syndrome
Anemia, Megaloblastic	Grasbeck-Imerslund Syndrome
Megaloblastic Anaemia	Mga1 Norwegian Type
Recessive Hereditary Megaloblastic Anaemia 1	Recessive Hereditary Megaloblastic Anemia 1
Rh-Mga1	Gräsbeck-Imerslund Disease
Pernicious Anemia, Juvenile, Due To Selective Intestinal Malabsorption Of Vitamin B12, With Proteinuria	Juvenile Pernicious Anemia With Proteinuria Due To Selective Intestinal Malabsorption Of Vitamin B12
Anemia Megaloblastic	Megaloblastic Anemia Due To Inborn Errors Of Metabolism
3-@Methylglutaconic Aciduria, Type I

Transcobalamin Ii Deficiency

TCN2 DEFICIENCY	Tc Ii Deficiency
Transcobalamin Deficiency	Tc Deficiency
Inherited Deficiency Of Transcobalamin

Diphyllobothriasis

Diphyllobothrium Infection	Fish Tapeworm
Bothriocephalosis	Infection By Bothriocephalus
Fish Tapeworm Infection	Dibothriocephalus Anaemia
Dibothriocephaliasis	Broad Tapeworm Infection
Bothriocephaliasis	Dibothriocephalus
Intestinal Diphyllobothriasis	Diphyllobothrium Infestation
Dibothriocephalus Infestation	Bothriocephalus Infestation
Adult Diphyllobothrium Infection	Tapeworm Anaemia
Infection By Diphyllobothrium Larvae

Ludwig'S Angina

Cellulitis Of Floor Of Mouth

Ludwig Angina

Autoimmune Gastritis

Vitamin Metabolic Disorder

Vitamin B12 Deficiency

Cobalamin Deficiency	Hypocobalaminemia
Vitamin B 12 Deficiency	Cyanocobalamin Deficiency
Deficiency Of Vitamin B12

Tropical Sprue

Tropical Steatorrhea	Tropical Enteropathy
Sprue, Tropical	Sprue - Tropical
Idiopathic Tropical Malabsorption Syndrome	Tropical Steatorrhoea
Tropical Diarrhoea	Ts - [Tropical Sprue]
Psilosis	Sprue Nos

Homocystinuria

Cystathionine Beta Synthase Deficiency	Homocysteinemia
Cbs Deficiency	Cystathionine Synthase Deficiency
Cystathionine Beta-Synthase Deficiency Disease

Copper Deficiency Myelopathy

Swayback

Human Swayback

Blind Loop Syndrome

Bacterial Overgrowth Syndrome

Pancytopenia

Necrotizing Fasciitis

Fasciitis, Necrotizing

Neural Tube Defects

Spina Bifida	Neural Tube Defect
NTD	Neural Tube Defects, Susceptibility To
Spinal Dysraphism	Spina Bifida, Susceptibility To
Rachischisis	Cleft Spine
Open Spine	Hydrocele Spinalis
Neural Tube Defect Nos	Sb - [Spina Bifida]
Spinal Hernia Nos	Spinal Fissure Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01999	CBLIF Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CBLIF	VGNC	VGNC:60423
Bos taurus	CBLIF	VGNC	VGNC:29354
Rattus norvegicus	CBLIF	RGD	RGD:62084
Mus musculus	CBLIF	MGD	MGI:1202394
Macaca mulatta	CBLIF	VGNC	VGNC:107435
Canis familiaris	CBLIF	VGNC	VGNC:41212

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