2. Gene
  3. SLC7A1 - solute carrier family 7 member 1 Gene

SLC7A1 - solute carrier family 7 member 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ERR; ATRC1; CAT-1; HCAT1; REC1L

Gene ID: 6541 | Gene type: protein coding

About SLC7A1

Cytogenetic location: 13q12.3 Genomic coordinates (GRCh38): 13:29,509,414-29,595,688 (from NCBI)

This gene has 3 transcripts (splice variants), 285 orthologues and 12 paralogues. Ubiquitous expression in esophagus (RPKM 22.4), brain (RPKM 11.3) and 24 other tissues.

Summary

Enables L-arginine transmembrane transporter activity and L-histidine transmembrane transporter activity. Involved in amino acid transport. Located in membrane. Part of apical plasma membrane; basolateral plasma membrane; and protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

SLC7A1 Products(1)

mRNA Protein Name
NM_003045.5 NP_003036.1 high affinity cationic amino acid transporter 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables L-arginine transmembrane transporter activity IDA
IDA: Inferred from direct assay
9174363 GOA
enables L-arginine transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
26449889 GOA
enables L-histidine transmembrane transporter activity IDA
IDA: Inferred from direct assay
11591158 GOA
enables L-lysine transmembrane transporter activity IDA
IDA: Inferred from direct assay
10485994 GOA
enables amino acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
28684763 GOA
enables basic amino acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
11891586 GOA
enables basic amino acid transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
17197568 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in L-amino acid transport IDA
IDA: Inferred from direct assay
28684763 GOA
involved in L-arginine transmembrane transport IDA
IDA: Inferred from direct assay
9174363 GOA
involved in L-arginine transmembrane transport IMP
IMP: Inferred from mutant phenotype
26449889 GOA
involved in L-histidine import across plasma membrane IDA
IDA: Inferred from direct assay
11591158 GOA
involved in amino acid import across plasma membrane IDA
IDA: Inferred from direct assay
28684763 GOA
involved in lysine transport IDA
IDA: Inferred from direct assay
11891586 GOA
involved in ornithine transport IMP
IMP: Inferred from mutant phenotype
17197568 GOA
acts upstream of positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
26449889 GOA
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
31791063 GOA
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
11891586 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
28112518 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
28246125 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC7A1 Protein Structure

AA_permease_2

AA_permease_2: Amino acid permease (32 - 437)

AA_permease_C

AA_permease_C: C-terminus of AA_permease (558 - 608)

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  • 629 a.a.
Protein Preferred Names Protein Names

high affinity cationic amino acid transporter 1

CAT1

SLC7A1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLC7A1 P30825 CCL4L1 Homo sapiens Q8NHW4
Validated Y2H
32296183
Intra
SLC7A1 P30825 TMBIM6 Homo sapiens P55061
Validated Y2H
32296183
Intra
SLC7A1 P30825 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
SLC7A1 P30825 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
SLC7A1 P30825 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
SLC7A1 P30825 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
SLC7A1 P30825 MS4A13 Homo sapiens Q5J8X5
Validated Y2H
32296183
Intra
SLC7A1 P30825 FAM241B Homo sapiens Q96D05-2
Validated Y2H
32296183
Intra
SLC7A1 P30825 TSPO2 Homo sapiens Q5TGU0
Validated Y2H
32296183
Intra
SLC7A1 P30825 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra
SLC7A1 P30825 SLC52A1 Homo sapiens Q9NWF4
Validated Y2H
32296183
Intra
SLC7A1 P30825 ST6GAL2 Homo sapiens Q96JF0-2
Validated Y2H
32296183
Intra
SLC7A1 P30825 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SLC7A1 P30825 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
SLC7A1 P30825 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
SLC7A1 P30825 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
SLC7A1 P30825 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 PDCD1LG2 Homo sapiens Q9BQ51
Validated Y2H
32296183
Intra
SLC7A1 P30825 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Array
32296183
Intra
SLC7A1 P30825 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra
SLC7A1 P30825 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra
SLC7A1 P30825 SLC18A2 Homo sapiens Q05940
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 SLC18A2 Homo sapiens Q05940
Y2H Array
32296183
Intra
SLC7A1 P30825 SLC18A2 Homo sapiens Q05940
Validated Y2H
32296183
Intra
SLC7A1 P30825 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra
SLC7A1 P30825 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
SLC7A1 P30825 GET1 Homo sapiens O00258
Y2H Array
32296183
Intra
SLC7A1 P30825 GET1 Homo sapiens O00258
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 CMTM2 Homo sapiens Q8TAZ6
Validated Y2H
32296183
Intra
SLC7A1 P30825 CMTM2 Homo sapiens Q8TAZ6
Y2H Array
32296183
Intra
SLC7A1 P30825 CMTM2 Homo sapiens Q8TAZ6
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 RNF144A Homo sapiens P50876
Validated Y2H
32296183
Intra
SLC7A1 P30825 RNF144A Homo sapiens P50876
Y2H Array
32296183
Intra
SLC7A1 P30825 RNF144A Homo sapiens P50876
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 CERS4 Homo sapiens Q9HA82
Validated Y2H
32296183
Intra
SLC7A1 P30825 CERS4 Homo sapiens Q9HA82
Y2H Array
32296183
Intra
SLC7A1 P30825 CERS4 Homo sapiens Q9HA82
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 TMEM14A Homo sapiens Q9Y6G1
Validated Y2H
32296183
Intra
SLC7A1 P30825 EMC6 Homo sapiens Q9BV81
Validated Y2H
32296183
Intra
SLC7A1 P30825 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
Intra
SLC7A1 P30825 HERPUD2 Homo sapiens Q9BSE4
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 HERPUD2 Homo sapiens Q9BSE4
Validated Y2H
32296183
Intra
SLC7A1 P30825 HERPUD2 Homo sapiens Q9BSE4
Y2H Array
32296183
Intra
SLC7A1 P30825 SACM1L Homo sapiens Q9NTJ5
Validated Y2H
32296183
Intra
SLC7A1 P30825 GALNT15 Homo sapiens Q8N3T1
Validated Y2H
32296183
Intra
SLC7A1 P30825 STIM1 Homo sapiens Q13586
Validated Y2H
32296183
Intra
SLC7A1 P30825 STIM1 Homo sapiens Q13586
Y2H Array
32296183
Intra
SLC7A1 P30825 STIM1 Homo sapiens Q13586
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 CD40 Homo sapiens P25942
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 CD40 Homo sapiens P25942
Y2H Array
32296183
Intra
SLC7A1 P30825 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
SLC7A1 P30825 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
SLC7A1 P30825 ORMDL3 Homo sapiens Q8N138
Validated Y2H
32296183
Intra
SLC7A1 P30825 MGST3 Homo sapiens O14880
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra
SLC7A1 P30825 TMEM19 Homo sapiens Q96HH6
Validated Y2H
32296183
Intra
SLC7A1 P30825 PTPN9 Homo sapiens P43378
Validated Y2H
32296183
Intra
SLC7A1 P30825 PTPN9 Homo sapiens P43378
Y2H Array
32296183
Intra
SLC7A1 P30825 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 FATE1 Homo sapiens Q969F0
Validated Y2H
25416956
Intra
SLC7A1 P30825 FATE1 Homo sapiens Q969F0
Validated Y2H
32296183
Intra
SLC7A1 P30825 FATE1 Homo sapiens Q969F0
Y2H Array
25416956
Intra
SLC7A1 P30825 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra
SLC7A1 P30825 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
25416956
Intra
SLC7A1 P30825 YIPF4 Homo sapiens Q9BSR8
Anti Tag CoIP
28514442
Intra
SLC7A1 P30825 YIPF4 Homo sapiens Q9BSR8
Validated Y2H
32296183
Intra
SLC7A1 P30825 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
SLC7A1 P30825 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
SLC7A1 P30825 SEC23A Homo sapiens Q15436
Validated Y2H
32296183
Intra
SLC7A1 P30825 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra
SLC7A1 P30825 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
Intra
SLC7A1 P30825 PNLIPRP1 Homo sapiens P54315
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Aids Phobia
Tinea Capitis

Dermatophytosis Of Scalp

Scalp Ringworm

Dermatophytosis Of Scalp Or Beard

Tinea Capitis Due To Trichophyton Rubrum

Trichophyton Rubrum Tinea Capitis
Decubitus Ulcer

Pressure Ulcer

Pressure Sores

Pressure Ulcers

Bedsore

Decubitus Ulcer

Decubitus Ulcer Any Site
Prolapse Of Urethra

Urethrocele
Chronic Ulcer Of Skin

Chronic Wounds

Callous Ulcer

Indolent Ulcer

Chronic Ulcer
Dermatophytosis

Tinea

Dermatophytosis, Unspecified

Ringworm

Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton

Cutaneous Mycosis

Dermal Mycosis

Superficial Mycosis, Unspecified

Fungus Infection Of Skin

Skin Mycosis

Dermatitis Fungoid

Fungal Dermatitis

Fungal Dermatosis

Mycotic Infection Of Skin
Amelogenesis Imperfecta, Type Ig

Enamel-Renal Syndrome

Ers

Amelogenesis Imperfecta Type 1g

AI1G

Enamel-Renal-Gingival Syndrome

Amelogenesis Imperfecta And Gingival Fibromatosis Syndrome

Aigfs

Amelogenesis Imperfecta, Hypoplastic, With Nephrocalcinosis

Amelogenesis Imperfecta Hypoplastic With Nephrocalcinosis

Amelogenesis Imperfecta Type Ig

Amelogenesis Imperfecta-Nephrocalcinosis Syndrome

Amelogenesis Imperfecta 1g

Hypoplastic Amelogenesis Imperfecta With Nephrocalcinosis

Amelogenesis Imperfecta Nephrocalcinosis
Subacute Leukemia
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13323 SLC7A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLC7A1 VGNC VGNC:77626
Mus musculus SLC7A1 MGD MGI:88117
Bos taurus SLC7A1 VGNC VGNC:34924
Canis familiaris SLC7A1 VGNC VGNC:46470
Felis catus SLC7A1 VGNC VGNC:65421
Rattus norvegicus SLC7A1 RGD RGD:3716
Others SLC7A1 NCBI