2. Gene
  3. FFAR2 - free fatty acid receptor 2 Gene

FFAR2 - free fatty acid receptor 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FFA2R; GPR43

Gene ID: 2867 | Gene type: protein coding

About FFAR2

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,448,257-35,451,767 (from NCBI)

This gene has 3 transcripts (splice variants), 333 orthologues and 15 paralogues. Biased expression in appendix (RPKM 7.9), bone marrow (RPKM 5.6) and 11 other tissues.

Summary

This gene encodes a member of the GP40 family of G protein-coupled receptors that are clustered together on chromosome 19. The encoded protein is a receptor for short chain free fatty acids and may be involved in the inflammatory response and in regulating lipid plasma levels. [provided by RefSeq, Apr 2009]

FFAR2 Products(2)

mRNA Protein Name
NM_001370087.1 NP_001357016.1 free fatty acid receptor 2
NM_005306.3 NP_005297.1 free fatty acid receptor 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables G protein-coupled receptor activity IDA
IDA: Inferred from direct assay
12496283 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21037097 GOA
Biological Process GO Annotation Evidence Reference Source
involved in G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
12496283 GOA
involved in cell surface pattern recognition receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
21037097 GOA
involved in cellular response to fatty acid IDA
IDA: Inferred from direct assay
12496283 GOA
involved in positive regulation of interleukin-8 production IMP
IMP: Inferred from mutant phenotype
21037097 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
18801738 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FFAR2 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (25 - 272)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
Protein Preferred Names Protein Names

free fatty acid receptor 2

G-protein coupled receptor 43

FFAR2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra FFAR2 O15552 EDDM3B Homo sapiens P56851
Validated Y2H
32296183
Intra FFAR2 O15552 SMAGP Homo sapiens Q0VAQ4
Validated Y2H
32296183
Intra FFAR2 O15552 TTMP Homo sapiens Q5BVD1
Validated Y2H
32296183
Intra FFAR2 O15552 RTP2 Homo sapiens Q5QGT7
Validated Y2H
32296183
Intra FFAR2 O15552 NRM Homo sapiens Q8IXM6
Validated Y2H
32296183
Intra FFAR2 O15552 CYB561A3 Homo sapiens Q8NBI2
Validated Y2H
32296183
Intra FFAR2 O15552 SLC35B4 Homo sapiens Q969S0
Validated Y2H
32296183
Intra FFAR2 O15552 TEX264 Homo sapiens Q9Y6I9
Validated Y2H
32296183
Intra FFAR2 O15552 RPRM Homo sapiens Q9NS64
Validated Y2H
32296183
Intra FFAR2 O15552 FAM20B Homo sapiens O75063
Validated Y2H
32296183
Intra FFAR2 O15552 AGTRAP Homo sapiens Q6RW13-2
Validated Y2H
32296183
Intra FFAR2 O15552 CMTM5 Homo sapiens Q96DZ9-2
Validated Y2H
32296183
Intra FFAR2 O15552 TMEM239 Homo sapiens Q8WW34-2
Validated Y2H
32296183
Intra FFAR2 O15552 CFHR5 Homo sapiens Q9BXR6
Validated Y2H
32296183
Intra FFAR2 O15552 O00602-PRO_0000009136 Homo sapiens O00602-PRO_0000009136
Y2H
21037097
Intra FFAR2 O15552 CLDND2 Homo sapiens Q8NHS1
Validated Y2H
32296183
Intra FFAR2 O15552 CLEC1A Homo sapiens Q8NC01
Validated Y2H
32296183
Intra FFAR2 O15552 C4orf3 Homo sapiens Q8WVX3-2
Validated Y2H
32296183
Intra FFAR2 O15552 KTN1 Homo sapiens Q86UP2-3
Validated Y2H
32296183
Intra FFAR2 O15552 TMEM86A Homo sapiens Q8N2M4
Validated Y2H
32296183
Intra FFAR2 O15552 LPAR3 Homo sapiens Q9UBY5
Validated Y2H
32296183
Intra FFAR2 O15552 ATP13A1 Homo sapiens Q9HD20-3
Validated Y2H
32296183
Intra FFAR2 O15552 MS4A13 Homo sapiens Q5J8X5
Validated Y2H
32296183
Intra FFAR2 O15552 TMEM97 Homo sapiens Q5BJF2
Validated Y2H
32296183
Intra FFAR2 O15552 FAXDC2 Homo sapiens Q96IV6
Validated Y2H
32296183
Intra FFAR2 O15552 CNIH1 Homo sapiens O95406
Validated Y2H
32296183
Intra FFAR2 O15552 FXYD3 Homo sapiens Q14802-3
Validated Y2H
32296183
Intra FFAR2 O15552 PLP1 Homo sapiens P60201-2
Validated Y2H
32296183
Intra FFAR2 O15552 TSPO2 Homo sapiens Q5TGU0
Validated Y2H
32296183
Intra FFAR2 O15552 STRIT1 Homo sapiens P0DN84
Validated Y2H
32296183
Intra FFAR2 O15552 COL4A5 Homo sapiens P29400-2
Validated Y2H
32296183
Intra FFAR2 O15552 UPK1B Homo sapiens O75841
Validated Y2H
32296183
Intra FFAR2 O15552 GUCA2A Homo sapiens Q02747
Validated Y2H
32296183
Intra FFAR2 O15552 SLC41A1 Homo sapiens Q8IVJ1
Validated Y2H
32296183
Intra FFAR2 O15552 TMEM203 Homo sapiens Q969S6
Validated Y2H
32296183
Intra FFAR2 O15552 SCGB1D1 Homo sapiens O95968
Validated Y2H
32296183
Intra FFAR2 O15552 TMEM144 Homo sapiens Q7Z5S9
Validated Y2H
32296183
Intra FFAR2 O15552 OR10AG1 Homo sapiens Q8NH19
Validated Y2H
32296183
Intra FFAR2 O15552 SLC35E3 Homo sapiens Q7Z769
Y2H Prey Pooling
32296183
Intra FFAR2 O15552 SLC35E3 Homo sapiens Q7Z769
Validated Y2H
32296183
Intra FFAR2 O15552 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra FFAR2 O15552 AGPAT4 Homo sapiens Q9NRZ5
Validated Y2H
32296183
Intra FFAR2 O15552 CGRRF1 Homo sapiens Q99675
Validated Y2H
32296183
Intra FFAR2 O15552 YIF1A Homo sapiens O95070
Validated Y2H
32296183
Intra FFAR2 O15552 CMTM7 Homo sapiens Q96FZ5
Validated Y2H
32296183
Intra FFAR2 O15552 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra FFAR2 O15552 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
Intra FFAR2 O15552 C11orf24 Homo sapiens Q96F05
Validated Y2H
32296183
Intra FFAR2 O15552 PMP22 Homo sapiens Q01453
Validated Y2H
32296183
Intra FFAR2 O15552 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra FFAR2 O15552 NAT8 Homo sapiens Q9UHE5
Validated Y2H
32296183
Intra FFAR2 O15552 FAM3C Homo sapiens Q92520
Validated Y2H
32296183
Intra FFAR2 O15552 GPR37L1 Homo sapiens O60883
Validated Y2H
32296183
Intra FFAR2 O15552 KRT1 Homo sapiens P04264
Validated Y2H
32296183
Intra FFAR2 O15552 FIS1 Homo sapiens Q9Y3D6
Validated Y2H
32296183
Intra FFAR2 O15552 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra FFAR2 O15552 TNF Homo sapiens P01375
Validated Y2H
32296183
Intra FFAR2 O15552 ALOX5AP Homo sapiens P20292
Validated Y2H
32296183
Intra FFAR2 O15552 GJB2 Homo sapiens P29033
Validated Y2H
32296183
Intra FFAR2 O15552 CXCL9 Homo sapiens Q07325
Validated Y2H
32296183
Intra FFAR2 O15552 SACM1L Homo sapiens Q9NTJ5
Validated Y2H
32296183
Intra FFAR2 O15552 NKG7 Homo sapiens Q16617
Validated Y2H
32296183
Intra FFAR2 O15552 MFSD5 Homo sapiens Q6N075
Validated Y2H
32296183
Intra FFAR2 O15552 BMP10 Homo sapiens O95393
Validated Y2H
32296183
Intra FFAR2 O15552 GALNT15 Homo sapiens Q8N3T1
Validated Y2H
32296183
Intra FFAR2 O15552 CBLIF Homo sapiens P27352
Validated Y2H
32296183
Intra FFAR2 O15552 DERL1 Homo sapiens Q9BUN8
Validated Y2H
32296183
Intra FFAR2 O15552 EMP1 Homo sapiens P54849
Validated Y2H
32296183
Intra FFAR2 O15552 NSG1 Homo sapiens P42857
Validated Y2H
32296183
Intra FFAR2 O15552 CD82 Homo sapiens P27701
Validated Y2H
32296183
Intra FFAR2 O15552 GYPA Homo sapiens P02724
Validated Y2H
32296183
Intra FFAR2 O15552 ERG28 Homo sapiens Q9UKR5
Validated Y2H
32296183
Intra FFAR2 O15552 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra FFAR2 O15552 APOD Homo sapiens P05090
Validated Y2H
32296183
Intra FFAR2 O15552 ATP6V0C Homo sapiens P27449
Validated Y2H
32296183
Intra FFAR2 O15552 LAPTM4A Homo sapiens Q15012
Validated Y2H
32296183
Intra FFAR2 O15552 TMEM11 Homo sapiens P17152
Validated Y2H
32296183
Intra FFAR2 O15552 SYNDIG1 Homo sapiens Q9H7V2
Validated Y2H
32296183
Intra FFAR2 O15552 STX8 Homo sapiens Q9UNK0
Validated Y2H
32296183
Intra FFAR2 O15552 FZD7 Homo sapiens O75084
Validated Y2H
32296183
Intra FFAR2 O15552 BNIP3 Homo sapiens Q12983
Validated Y2H
32296183
Intra FFAR2 O15552 MALL Homo sapiens Q13021
Validated Y2H
32296183
Intra FFAR2 O15552 LEPROTL1 Homo sapiens O95214
Validated Y2H
32296183
Intra FFAR2 O15552 YIPF2 Homo sapiens Q9BWQ6
Validated Y2H
32296183
Intra FFAR2 O15552 YIPF6 Homo sapiens Q96EC8
Validated Y2H
32296183
Intra FFAR2 O15552 UNC50 Homo sapiens Q53HI1
Validated Y2H
32296183
Intra FFAR2 O15552 IFITM3 Homo sapiens Q01628
Validated Y2H
32296183
Intra FFAR2 O15552 LAT Homo sapiens O43561-2
Validated Y2H
32296183
Intra FFAR2 O15552 RUSF1 Homo sapiens Q96GQ5
Validated Y2H
32296183
Intra FFAR2 O15552 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
Intra FFAR2 O15552 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
Intra FFAR2 O15552 BTN2A2 Homo sapiens Q8WVV5
Validated Y2H
32296183
Intra FFAR2 O15552 TM4SF4 Homo sapiens P48230
Validated Y2H
32296183
Intra FFAR2 O15552 PNLIPRP1 Homo sapiens P54315
Validated Y2H
32296183
Intra FFAR2 O15552 CCDC167 Homo sapiens Q9P0B6
Validated Y2H
32296183
Intra FFAR2 O15552 NIPAL4 Homo sapiens Q0D2K0
Validated Y2H
32296183
Intra FFAR2 O15552 SELENOK Homo sapiens Q9Y6D0
Validated Y2H
32296183
Intra FFAR2 O15552 CACNG1 Homo sapiens Q06432
Validated Y2H
32296183
Intra FFAR2 O15552 PEX16 Homo sapiens Q9Y5Y5
Validated Y2H
32296183
Intra FFAR2 O15552 SLC38A1 Homo sapiens Q9H2H9
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Diversion Colitis
Inflammatory Bowel Disease 16

IBD16

Inflammatory Bowel Disease 16, Susceptibility To
Constipation
Autotopagnosia

Body-Image Agnosia
Anaerobic Meningitis
Noonan Syndrome 8

NS8

Noonan Syndrome, Type 8
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16257 Ffar2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-114060 CFMB / Unkown
HY-RS04875 FFAR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris FFAR2 VGNC VGNC:40831
Macaca mulatta FFAR2 VGNC VGNC:72706
Mus musculus FFAR2 MGD MGI:2441731
Rattus norvegicus FFAR2 RGD RGD:1359614