Ecsit - ECSIT signalling integrator Gene

Mus musculus

Also known as Sitpec

Gene ID: 26940 | Gene type: protein coding

About Ecsit

Summary

Enables DNA-binding transcription factor activity and chromatin binding activity. Acts upstream of or within BMP signaling pathway; mesoderm formation; and regulation of transcription by RNA polymerase II. Located in mitochondrion. Part of transcription regulator complex. Is expressed in several structures, including egg cylinder; embryo mesoderm; and genitourinary system. Orthologous to human ECSIT (ECSIT signaling integrator). [provided by Alliance of Genome Resources, Apr 2022]

Ecsit Products(3)

mRNA	Protein	Name
NM_001253897.1	NP_001240826.1	evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor
NM_001253898.1	NP_001240827.1	evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor
NM_012029.2	NP_036159.1	evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	14633973	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	14633973	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10465784	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within BMP signaling pathway	IDA IDA: Inferred from direct assay	14633973	MGI
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway	IDA IDA: Inferred from direct assay	10465784	MGI
acts upstream of or within cell surface receptor protein serine/threonine kinase signaling pathway	IPI IPI: Inferred from physical interaction	10465784	MGI
acts upstream of or within mesoderm formation	IMP IMP: Inferred from mutant phenotype	14633973	MGI
acts upstream of or within regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	14633973	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrion	IDA IDA: Inferred from direct assay	22588174	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	14633973	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

ECSIT homolog

signaling intermediate in Toll pathway-evolutionarily conserved

Ecsit Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Ecsit	Q9QZH6	TRAF6	Homo sapiens	Q9Y4K3	CoIP	10465784
Intra	Ecsit	Q9QZH6	Rps27a	Mus musculus	P62991	Anti Tag CoIP	21525932
Intra	Ecsit	Q9QZH6	Rps27a	Mus musculus	P62991	Anti Bait CoIP	21525932
Intra	Ecsit	Q9QZH6	Traf6	Mus musculus	P70196	Pull Down	10465784
Intra	Ecsit	Q9QZH6	Traf6	Mus musculus	P70196	Anti Bait CoIP	21525932

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04148	ECSIT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ecsit	NCBI	NCBI:51295

Name
Email *

	Sorry, but the email address you supplied was invalid.