Afdn - afadin, adherens junction formation factor Gene

Rattus norvegicus

Also known as Af6; Mllt4

Gene ID: 26955 | Gene type: protein coding

About Afdn

Summary

Enables LIM domain binding activity. Involved in dendrite arborization; positive regulation of mini excitatory postsynaptic potential; and regulation of cell morphogenesis. Located in adherens junction; axon; and somatodendritic compartment. Colocalizes with excitatory synapse. Orthologous to human AFDN (afadin, adherens junction formation factor). [provided by Alliance of Genome Resources, Apr 2022]

Afdn Products(1)

mRNA	Protein	Name
NM_013217.3	NP_037349.1	afadin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables LIM domain binding	IPI IPI: Inferred from physical interaction	15140894	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10974003	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in dendrite arborization	IMP IMP: Inferred from mutant phenotype	22948147	RGD
involved in positive regulation of dendrite extension	IMP IMP: Inferred from mutant phenotype	22948147	RGD
involved in positive regulation of dendrite morphogenesis	IMP IMP: Inferred from mutant phenotype	22948147	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	22948147	RGD
involved in positive regulation of mini excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	22948147	RGD
involved in postsynaptic specialization organization	IDA IDA: Inferred from direct assay	36803960	RGD
involved in postsynaptic specialization organization	IMP IMP: Inferred from mutant phenotype	36803960	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	9334353	RGD
located in axon	IDA IDA: Inferred from direct assay	18181141	RGD
located in excitatory synapse	IDA IDA: Inferred from direct assay	22948147	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	36803960	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	36803960	RGD
located in somatodendritic compartment	IDA IDA: Inferred from direct assay	18181141	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

afadin

myeloid/lymphoid or mixed lineage-leukemia translocation to 4 homolog	myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)	translocated to, 4
myeloid/lymp

Afdn Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Afdn	O35889	DBN1	Homo sapiens	Q16643	Pull Down	23750010
Cross	Afdn	O35889	DBN1	Homo sapiens	Q16643	Anti Tag CoIP	23750010
Cross	Afdn	O35889	DBN1	Homo sapiens	Q16643	FRAP	23750010
Cross	Afdn	O35889	Ctnna1	Mus musculus	P26231	Pull Down	10974003
Cross	Afdn	O35889	Ctnna1	Mus musculus	P26231	Y2H	10974003

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00427	AFDN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Afdn	NCBI	NCBI:4301

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