1. Gene
  2. HDAC3 - histone deacetylase 3 Gene

HDAC3 - histone deacetylase 3 Gene

Homo sapiens

Also known as HD3; RPD3; KDAC3; RPD3-2

Gene ID: 8841 | Gene type: protein coding

About HDAC3

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:141,620,881-141,636,849 (from NCBI)

This gene has 16 transcripts (splice variants), 155 orthologues and 10 paralogues. Ubiquitous expression in lymph node (RPKM 21.1), adrenal (RPKM 20.9) and 25 other tissues.

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and Apoptosis. This gene is regarded as a potential tumor suppressor gene. [provided by RefSeq, Jul 2008]

HDAC3 Products(10)

mRNA Protein Name
NR_149169.2
NM_001355041.2 NP_001341970.1 histone deacetylase 3 isoform 4
NR_149167.2
NM_001355040.2 NP_001341969.1 histone deacetylase 3 isoform 3
NR_149166.2
NR_149164.2
NM_003883.4 NP_003874.2 histone deacetylase 3 isoform 2
NR_149168.2
NR_149165.2
NM_001355039.2 NP_001341968.1 histone deacetylase 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables NF-kappaB binding IPI
IPI: Inferred from physical interaction
17785205 GOA
enables chromatin binding IDA
IDA: Inferred from direct assay
16569215 GOA
enables cyclin binding IPI
IPI: Inferred from physical interaction
18417529 GOA
enables enzyme binding IPI
IPI: Inferred from physical interaction
11641274 GOA
enables histone deacetylase activity IDA
IDA: Inferred from direct assay
28497810 GOA
enables histone deacetylase activity IMP
IMP: Inferred from mutant phenotype
16924111 GOA
enables histone deacetylase binding IPI
IPI: Inferred from physical interaction
10869435 GOA
enables histone decrotonylase activity IDA
IDA: Inferred from direct assay
28497810 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11006275 GOA
enables protein de-2-hydroxyisobutyrylase activity IDA
IDA: Inferred from direct assay
29192674 GOA
enables protein decrotonylase activity IDA
IDA: Inferred from direct assay
34608293 GOA
enables protein lysine deacetylase activity IDA
IDA: Inferred from direct assay
15653507 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
16569215 GOA
enables transcription corepressor activity IMP
IMP: Inferred from mutant phenotype
12628926 GOA
enables transcription corepressor binding IPI
IPI: Inferred from physical interaction
10898795 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA repair-dependent chromatin remodeling IDA
IDA: Inferred from direct assay
25301942 GOA
involved in cellular response to fluid shear stress IDA
IDA: Inferred from direct assay
25190803 GOA
involved in establishment of mitotic spindle orientation IDA
IDA: Inferred from direct assay
34608293 GOA
involved in negative regulation of DNA-templated transcription IMP
IMP: Inferred from mutant phenotype
16924111 GOA
involved in negative regulation of JNK cascade IMP
IMP: Inferred from mutant phenotype
11931768 GOA
NOT involved in negative regulation of myotube differentiation IMP
IMP: Inferred from mutant phenotype
10983972 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16569215 GOA
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12628926 GOA
involved in positive regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
25190803 GOA
involved in positive regulation of protein import into nucleus IDA
IDA: Inferred from direct assay
25190803 GOA
involved in positive regulation of protein phosphorylation IDA
IDA: Inferred from direct assay
25190803 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
25190803 GOA
involved in protein deacetylation IDA
IDA: Inferred from direct assay
21030595 GOA
involved in regulation of protein stability IDA
IDA: Inferred from direct assay
25190803 GOA
involved in spindle assembly IMP
IMP: Inferred from mutant phenotype
18326024 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25190803 GOA
located in cytosol IDA
IDA: Inferred from direct assay
21030595 GOA
part of histone deacetylase complex IDA
IDA: Inferred from direct assay
18326024 GOA
located in mitotic spindle IDA
IDA: Inferred from direct assay
18326024 GOA
located in nucleus IDA
IDA: Inferred from direct assay
18326024 GOA
part of transcription repressor complex IDA
IDA: Inferred from direct assay
11804585 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDAC3 Protein Structure

Hist_deacetyl

Hist_deacetyl: Histone deacetylase domain (18 - 314)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 428 a.a.
Protein Preferred Names Protein Names

histone deacetylase 3

SMAP45

protein deacetylase HDAC3

protein deacylase HDAC3

HDAC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra HDAC3 O15379 AKAP8 Homo sapiens O43823
Confocal
16980585
Intra HDAC3 O15379 AKAP8 Homo sapiens O43823
Anti Tag CoIP
16980585
Intra HDAC3 O15379 AKAP8 Homo sapiens O43823
Anti Bait CoIP
16980585
Intra HDAC3 O15379 SUZ12 Homo sapiens Q15022
Anti Bait CoIP
23079660
Intra HDAC3 O15379 NCOR1 Homo sapiens O75376
Anti Tag CoIP
23752268
Intra HDAC3 O15379 NCOR1 Homo sapiens O75376
Anti Tag CoIP
35271311
Intra HDAC3 O15379 NCOR1 Homo sapiens O75376
Affinity Chrom
11013263
Intra HDAC3 O15379 NCOR1 Homo sapiens O75376
Anti Tag CoIP
16980585
Intra HDAC3 O15379 NCOR1 Homo sapiens O75376
Anti Bait CoIP
21258344
Cross HDAC3 O15379 Ncor1 Mus musculus Q60974
Anti Tag CoIP
16917504
Cross HDAC3 O15379 Ncor1 Mus musculus Q60974
Anti Tag CoIP
17956988
Intra HDAC3 O15379 AKAP8L Homo sapiens Q9ULX6
Anti Tag CoIP
16980585
Intra HDAC3 O15379 AKAP8L Homo sapiens Q9ULX6
Anti Bait CoIP
16980585
Intra HDAC3 O15379 MYC Homo sapiens P01106
Anti Bait CoIP
23079660
Intra HDAC3 O15379 MYC Homo sapiens P01106
CH-IP
23079660
Intra HDAC3 O15379 MAGEA2 Homo sapiens P43356
Anti Tag CoIP
16847267
Intra HDAC3 O15379 PGK1 Homo sapiens P00558
Anti Bait CoIP
26356530
Intra HDAC3 O15379 PGK1 Homo sapiens P00558
Anti Tag CoIP
26356530
Intra HDAC3 O15379 KDM1A Homo sapiens O60341
Confocal
23752268
Intra HDAC3 O15379 KDM1A Homo sapiens O60341
Anti Tag CoIP
23752268
Intra HDAC3 O15379 KDM1A Homo sapiens O60341
Anti Bait CoIP
21258344
Intra HDAC3 O15379 GPS2 Homo sapiens Q13227
Anti Tag CoIP
23752268
Intra HDAC3 O15379 GPS2 Homo sapiens Q13227
Anti Bait CoIP
21258344
Intra HDAC3 O15379 GPS2 Homo sapiens Q13227
Anti Tag CoIP
35271311
Intra HDAC3 O15379 GPS2 Homo sapiens Q13227
Anti Tag CoIP
16980585
Intra HDAC3 O15379 L3MBTL2 Homo sapiens Q969R5
IF
20385135
Intra HDAC3 O15379 L3MBTL2 Homo sapiens Q969R5
Pull Down
20385135
Intra HDAC3 O15379 APPL1 Homo sapiens Q9UKG1
Anti Bait CoIP
23752268
Intra HDAC3 O15379 APPL1 Homo sapiens Q9UKG1
Anti Tag CoIP
23752268
Intra HDAC3 O15379 NRIP1 Homo sapiens P48552
Y2H
17053781
Intra HDAC3 O15379 NRIP1 Homo sapiens P48552
Anti Bait CoIP
17053781
Intra HDAC3 O15379 NCOR2 Homo sapiens Q9Y618
X-Ray Diffraction
22230954
Intra HDAC3 O15379 NCOR2 Homo sapiens Q9Y618
Anti Tag CoIP
22230954
Intra HDAC3 O15379 NCOR2 Homo sapiens Q9Y618
Anti Bait CoIP
21624135
Intra HDAC3 O15379 NCOR2 Homo sapiens Q9Y618
Anti Bait CoIP
21258344
Intra HDAC3 O15379 NCOR2 Homo sapiens Q9Y618
Anti Bait CoIP
16980585
Intra HDAC3 O15379 NCOR2 Homo sapiens Q9Y618
Deacetylase Assay
22230954
Intra HDAC3 O15379 NCOR2 Homo sapiens Q9Y618
GMS
22230954
Intra HDAC3 O15379 NCOR2 Homo sapiens Q9Y618
Anti Tag CoIP
23752268
Intra HDAC3 O15379 NCOR2 Homo sapiens Q9Y618
Anti Tag CoIP
35271311
Intra HDAC3 O15379 NCOR2 Homo sapiens Q9Y618
Anti Tag CoIP
16980585
Intra HDAC3 O15379 NCOR2 Homo sapiens Q9Y618
Anti Bait CoIP
16924111
Intra HDAC3 O15379 MBD1 Homo sapiens Q9UIS9
Anti Tag CoIP
16432238
Cross HDAC3 O15379 ICP0 Human herpesvirus 1 P08393
CoIP
15194749
Cross HDAC3 O15379 ICP0 Human herpesvirus 1 P08393
Pull Down
15194749
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Optic Atrophy 10 With Or Without Ataxia, Mental Retardation, And Seizures

OPA10

Optic Atrophy 10 With Or Without Ataxia, Intellectual Disability, And Seizures

Optic Atrophy 10

Atrophy, Optic, Type 10, With/Without Ataxia, Mental Retardation, And Seizures

Retinoblastoma

RB

Trilateral Retinoblastoma

RB1

Retinoblastoma, Trilateral

Neuroblastoma Of Retina

Rb - Retinoblastoma

Eye Cancer, Retinoblastoma

Retinal Cancer

Retinal Tumor

Glioma, Retinal

Non-Hereditary Retinoblastoma

Childhood Cancer Retinoblastoma

Malignant Neoplasm Of Retina

Retinal Neoplasms

Rett Syndrome

Atypical Rett Syndrome

RTT

Rts

Autism, Dementia, Ataxia, And Loss Of Purposeful Hand Use

Rett Syndrome, Atypical

Rett Syndrome, Preserved Speech Variant

Rett'S Disorder

Rett Syndrome Variant

Rett Disorder

Cerebroatrophic Hyperammonemia

Rett Like Syndrome

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use Syndrome

Rett'S Syndrome

Atypical Rtt

Autism-Dementia-Ataxia-Loss Of Purposeful Hand Use

Rett Syndrome Preserved Speech Variant

Rett Syndrome Zappella Variant

Rett Syndrome, Zappella Variant

Acute Promyelocytic Leukemia

Leukemia, Acute Promyelocytic

Acute Myeloblastic Leukemia Type 3

Aml M3

APL

Leukemia, Acute Promyelocytic, Somatic

Aml With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Apml

Acute Myeloblastic Leukemia 3

Acute Myeloid Leukemia With T(15

17)(Q22

Q12)

(Pml/Raralpha) And Variants

Acute Myeloblastic Leukaemia Type 3

Acute Myeloid Leukaemia M3

Acute Myeloid Leukemia M3

Acute Promyelocytic Leukaemia

M3 Anll

Myeloid Leukemia, Acute, M3

Leukemia Promyelocytic Acute

Leukemia, Promyelocytic, Acute

Leukemia, Acute, Promyelocytic

Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus HDAC3 VGNC VGNC:67549
Canis familiaris HDAC3 VGNC VGNC:50628
Rattus norvegicus HDAC3 RGD RGD:619977
Mus musculus HDAC3 MGD MGI:1343091
Bos taurus HDAC3 VGNC VGNC:106764
Macaca mulatta HDAC3 VGNC VGNC:73359