Ephb1 - Eph receptor B1 Gene

Mus musculus

Also known as Elk; Net; Cek6; Elkh; Hek6; 9330129L11; C130099E04Rik

Gene ID: 270190 | Gene type: protein coding

About Ephb1

Summary

Enables axon guidance receptor activity. Involved in several processes, including dendritic spine morphogenesis; detection of temperature stimulus involved in sensory perception of pain; and negative regulation of satellite cell differentiation. Acts upstream of or within several processes, including axonogenesis; Ephrin Receptor signaling pathway; and optic nerve morphogenesis. Located in several cellular components, including axon; filopodium tip; and membrane raft. Is active in glutamatergic synapse. Is expressed in several structures, including 1st branchial arch; brain; lower urinary tract; sensory organ; and vascular system. Orthologous to human EphB1 (EPH receptor B1). [provided by Alliance of Genome Resources, Apr 2022]

Ephb1 Products(2)

mRNA	Protein	Name
NM_001168296.1	NP_001161768.1	ephrin type-B receptor 1 isoform 2 precursor
NM_173447.3	NP_775623.3	ephrin type-B receptor 1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables axon guidance receptor activity	IDA IDA: Inferred from direct assay	11532925	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12925710	MGI
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17310244	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within axon guidance	IDA IDA: Inferred from direct assay	11532925	MGI
acts upstream of or within axon guidance	IMP IMP: Inferred from mutant phenotype	12971893	MGI
acts upstream of or within camera-type eye morphogenesis	IMP IMP: Inferred from mutant phenotype	12971893	MGI
involved in cell chemotaxis	IMP IMP: Inferred from mutant phenotype	18057206	MGI
acts upstream of or within central nervous system projection neuron axonogenesis	IDA IDA: Inferred from direct assay	12971893	MGI
acts upstream of or within central nervous system projection neuron axonogenesis	IMP IMP: Inferred from mutant phenotype	12971893	MGI
acts upstream of or within cranial nerve development	IMP IMP: Inferred from mutant phenotype	12971893	MGI
involved in dendritic spine development	IMP IMP: Inferred from mutant phenotype	14691139	MGI
acts upstream of or within dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	17310244	MGI
involved in dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	14691139	MGI
involved in detection of temperature stimulus involved in sensory perception of pain	IMP IMP: Inferred from mutant phenotype	19025592	MGI
acts upstream of or within ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	17310244	MGI
involved in establishment of cell polarity	IMP IMP: Inferred from mutant phenotype	18057206	MGI
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	19523204	MGI
involved in modulation of chemical synaptic transmission	IEP IEP: Inferred from expression pattern	19523204	MGI
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	19523204	MGI
involved in negative regulation of satellite cell differentiation	IMP IMP: Inferred from mutant phenotype	27446912	MGI
involved in negative regulation of skeletal muscle satellite cell proliferation	IMP IMP: Inferred from mutant phenotype	27446912	MGI
involved in neural precursor cell proliferation	IMP IMP: Inferred from mutant phenotype	18057206	MGI
involved in neurogenesis	IMP IMP: Inferred from mutant phenotype	18057206	MGI
acts upstream of or within optic nerve morphogenesis	IMP IMP: Inferred from mutant phenotype	12971893	MGI
involved in positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	14691139	MGI
acts upstream of or within retinal ganglion cell axon guidance	IDA IDA: Inferred from direct assay	12971893	MGI
involved in skeletal muscle satellite cell activation	IMP IMP: Inferred from mutant phenotype	27446912	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	16701205	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12093895	MGI
located in filopodium tip	IDA IDA: Inferred from direct assay	24305805	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19523204	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	19523204	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	19523204	MGI
located in membrane	IDA IDA: Inferred from direct assay	12093895	MGI
located in membrane raft	IDA IDA: Inferred from direct assay	15502157	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ephrin type-B receptor 1

Recombinant Ephb1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75747	EphB1 Protein, Mouse (sf9, His-GST)	Q8CBF3-1 (M591-A984)	≥95%
HY-P75748	EphB1 Protein, Mouse (HEK293, His)	Q8CBF3-1 (M18-L539)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115481	EphB1-IN-1	Inhibitor	99.87%	Unkown
HY-RS04433	EPHB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ephb1	NCBI	NCBI:2047
Macaca mulatta	Ephb1	NCBI	NCBI:717211

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