EPHB1 - EPH receptor B1 Gene

Homo sapiens

Also known as ELK; NET; Hek6; EPHT2

Gene ID: 2047 | Gene type: protein coding

About EPHB1

Cytogenetic location: 3q22.2 Genomic coordinates (GRCh38): 3:134,795,260-135,260,467 (from NCBI)

This gene has 9 transcripts (splice variants), 238 orthologues and 53 paralogues. Biased expression in brain (RPKM 6.3), testis (RPKM 3.5) and 8 other tissues.

Summary

Ephrin receptors and their ligands, the Ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]

EPHB1 Products(1)

mRNA	Protein	Name
NM_004441.5	NP_004432.1	ephrin type-B receptor 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	8798570	GOA
enables transmembrane-ephrin receptor activity	IDA IDA: Inferred from direct assay	18034775	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IDA IDA: Inferred from direct assay	9499402	GOA
involved in cell chemotaxis	IDA IDA: Inferred from direct assay	12925710	GOA
involved in cell-substrate adhesion	IDA IDA: Inferred from direct assay	9430661	GOA
involved in ephrin receptor signaling pathway	IDA IDA: Inferred from direct assay	12925710	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	18034775	GOA
involved in regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	12925710	GOA
involved in regulation of JNK cascade	IDA IDA: Inferred from direct assay	9430661	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in early endosome membrane	IDA IDA: Inferred from direct assay	18034775	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	18034775	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPHB1 Protein Structure

Ephrin_lbd

fn3

EphA2_TM

Pkinase_Tyr

SAM_1

0
200
400
600
800
984 a.a.

Protein Preferred Names

Protein Names

ephrin type-B receptor 1

EK6

EPHB1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	EPHB1	P54762	GRB2	Homo sapiens	P62993	CoIP	8798570
Intra	EPHB1	P54762	GRB10	Homo sapiens	Q13322	CoIP	8798570
Intra	EPHB1	P54762	GRB7	Homo sapiens	Q14451	Pull Down	12223469
Intra	EPHB1	P54762	GRB7	Homo sapiens	Q14451	Y2H	12223469

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EPHB1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70381	EphB1 Protein, Human (HEK293, Fc)	P54762-1 (M18-P540)	≥95%
HY-P72997	EphB1 Protein, Human (sf9, His-GST)	AAI11745.1 (R565-A984)	≥95%
HY-P72998	EphB1 Protein, Human (HEK293, His)	P54762-1 (M18-P540)	≥95%

EPHB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82431	Ephrin Receptor B1 Antibody (YA2176)	WB, IP	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Craniofrontonasal Syndrome

Craniofrontonasal Dysplasia	CFNS
Cfnd	Craniofrontonasal Dysostosis
Craniofrontonasal Dystosis	Dysplasia, Craniofrontonasal

Ovary Serous Adenocarcinoma

Malignant Ovarian Serous Tumor

Serous Carcinoma Of Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-115481	EphB1-IN-1	Inhibitor	99.87%	Unkown
HY-RS04433	EPHB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	EPHB1	VGNC	VGNC:72241
Canis familiaris	EPHB1	VGNC	VGNC:49889
Bos taurus	EPHB1	VGNC	VGNC:50173
Mus musculus	EPHB1	MGD	MGI:1096337
Rattus norvegicus	EPHB1	RGD	RGD:2556
Felis catus	EPHB1	VGNC	VGNC:61906
Others	EPHB1	NCBI

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