NOX1 - NADPH oxidase 1 Gene

Homo sapiens

Also known as MOX1; NOH1; NOH-1; GP91-2; NOH-1L

Gene ID: 27035 | Gene type: protein coding

About NOX1

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:100,843,324-100,874,359 (from NCBI)

This gene has 5 transcripts (splice variants), 126 orthologues and 6 paralogues. Restricted expression toward colon (RPKM 30.7).

Summary

This gene encodes a member of the NADPH Oxidase family of Enzymes responsible for the catalytic one-electron transfer of oxygen to generate superoxide or hydrogen peroxide. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]

NOX1 Products(5)

mRNA	Protein	Name
NM_007052.5	NP_008983.2	NADPH oxidase 1 isoform 1
NM_001271815.2	NP_001258744.1	NADPH oxidase 1 isoform 3
NM_013955.3	NP_039249.1	NADPH oxidase 1 isoform 2
XM_017029407.3	XP_016884896.1	NADPH oxidase 1 isoform X1
NM_013954.1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16329988	GOA
enables small GTPase binding	IPI IPI: Inferred from physical interaction	16636067	GOA
enables superoxide-generating NAD(P)H oxidase activity	IDA IDA: Inferred from direct assay	14617635	GOA
enables superoxide-generating NAD(P)H oxidase activity	IMP IMP: Inferred from mutant phenotype	18023288	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	11805326	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	18023288	GOA
involved in hydrogen peroxide metabolic process	IDA IDA: Inferred from direct assay	11331784	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	10485709	GOA
involved in positive regulation of integrin biosynthetic process	IMP IMP: Inferred from mutant phenotype	18023288	GOA
involved in positive regulation of vascular endothelial growth factor production	IEP IEP: Inferred from expression pattern	11805326	GOA
involved in superoxide anion generation	IDA IDA: Inferred from direct assay	10485709	GOA
involved in superoxide anion generation	IMP IMP: Inferred from mutant phenotype	18023288	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NADPH oxidase complex	IDA IDA: Inferred from direct assay	16636067	GOA
located in early endosome	IDA IDA: Inferred from direct assay	17673675	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	14617635	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NOX1 Protein Structure

Ferric_reduct

FAD_binding_8

NAD_binding_6

0
100
200
300
400
500
564 a.a.

Protein Preferred Names

Protein Names

NADPH oxidase 1

NADH/NADPH mitogenic oxidase subunit P65-MOX	NADPH oxidase homolog-1
mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating)	mitogenic oxidase 1

NOX1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NOX1	Q9Y5S8	TBXA2R	Homo sapiens	Q0VAB0	Y2H Array	32296183
Intra	NOX1	Q9Y5S8	TBXA2R	Homo sapiens	Q0VAB0	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Granulomatous Disease, Chronic, Autosomal Recessive, 1

Chronic Granulomatous Disease Due To Deficiency Of Ncf-1	CGD1
Ncf1 Deficiency	Soluble Oxidase Component Ii Deficiency
Soc2 Deficiency	P47-Phox Deficiency
Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Positive Type I	Deficiency Of Neutrophil Cytosol Factor 1
Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type 1	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Positive, Type I
Cgd, Autosomal Recessive Cytochrome B-Positive, Type I	Granulomatous Disease, Chronic, Due To Ncf1 Deficiency
Neutrophil Cytosol Factor 1 Deficiency	Chronic Granulomatous Disease 1, Autosomal Recessive
Autosomal Recessive Chronic Granulomatous Disease 1	Cdg1
Deficiency Of Ncf1	Deficiency Of P47-Phox
Deficiency Of Soc2	Deficiency Of Soluble Oxidase Component Ii
Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Positive Type I	Chronic Granulomatous Disease Due To Ncf1 Deficiency

Vascular Disease

Vascular Diseases	Aneurysm
Spinal Cord Ischemia	Spinal Cord Vascular Diseases
Vascular Tissue Disease	Vascular Anomaly

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Diabetes Mellitus

Diabetes

Diabetic Angiopathy

Diabetic Angiopathies	Diabetic Peripheral Angiopathy
Diabetic Vascular Disorder

Ileocolitis

Iieocolitis

Granulomatous Disease, Chronic, Autosomal Recessive, 4

Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative	Cyba Deficiency
CGD4	Cgd Due To Deficiency Of The Alpha Subunit Of Cytochrome B
Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Negative	Cgd, Autosomal Recessive Cytochrome B-Negative
Chronic Granulomatous Disease 4, Autosomal Recessive	Autosomal Recessive Chronic Granulomatous Disease 4
Autosomal Recessive Cytochrome B-Negative Cgd	Chronic Granulomatous Disease Due To Deficiency Of Cyba
Cgd Due To Deficiency Of Alpha Subunit Of Cytochrome B	Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Negative
Granulomatous Disease, Chronic, Cytochrome-B-Negative, Autosomal Recessive

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Phagocyte Bactericidal Dysfunction

Phagocytic Dysfunction

Chronic Granulomatous Disease

Cgd	Granulomatous Disease, Chronic
Autosomal Recessive Chronic Granulomatous Disease	X-Linked Chronic Granulomatous Disease
Bridges-Good Syndrome	Congenital Dysphagocytosis
Quie Syndrome	Chronic Septic Granulomatosis
Chronic Granulomatous Disorder	Granulomatous Disease Chronic
Granulomatous Disease, Chronic, X-Linked

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12298	Setanaxib	Inhibitor	99.75%	Phase 3
HY-120801	APX-115	Inhibitor	99.08%	Phase 2
HY-120801A	APX-115 free base	Inhibitor	98.11%	Phase 2

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12805	ML171	Inhibitor	99.82%	Unkown
HY-101499	GKT136901	Inhibitor	99.70%	Unkown
HY-P1435	NoxA1ds	Inhibitor	95.19%	Unkown
HY-126195	Fluoflavine	Inhibitor	99.41%	Unkown
HY-105946	Hidrosmin	Inhibitor	/	Unkown
HY-P1435A	NoxA1ds TFA	Inhibitor	/	Unkown
HY-128004	ML171 analog 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	NOX1	VGNC	VGNC:75374
Rattus norvegicus	NOX1	RGD	RGD:620598
Mus musculus	NOX1	MGD	MGI:2450016
Bos taurus	NOX1	VGNC	VGNC:32182
Felis catus	NOX1	VGNC	VGNC:68522
Canis familiaris	NOX1	VGNC	VGNC:43903

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