TRMT2A - tRNA methyltransferase 2 homolog A Gene

Homo sapiens

Also known as HTF9C

Gene ID: 27037 | Gene type: protein coding

About TRMT2A

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,111,875-20,117,226 (from NCBI)

This gene has 18 transcripts (splice variants), 201 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 11.1), testis (RPKM 10.2) and 25 other tissues.

Summary

The protein encoded by this gene is of unknown function. However, it is orthologous to the mouse Trmt2a gene and contains an RNA methyltransferase domain. Expression of this gene varies during the cell cycle, with aberrant expression being a possible biomarker in certain breast cancers. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

TRMT2A Products(4)

mRNA	Protein	Name
NM_001257994.2	NP_001244923.1	tRNA (uracil-5-)-methyltransferase homolog A isoform b
NM_001331039.2	NP_001317968.1	tRNA (uracil-5-)-methyltransferase homolog A isoform c
NM_022727.6	NP_073564.3	tRNA (uracil-5-)-methyltransferase homolog A isoform a
NM_182984.5	NP_892029.2	tRNA (uracil-5-)-methyltransferase homolog A isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables C-methyltransferase activity	IDA IDA: Inferred from direct assay	34123281	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables tRNA (uracil(54)-C5)-methyltransferase activity, S-adenosyl methionine-dependent	IDA IDA: Inferred from direct assay	31361898	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRMT2A Protein Structure

tRNA_U5-meth_tr

0
100
200
300
400
500
625 a.a.

Protein Preferred Names

Protein Names

tRNA (uracil-5-)-methyltransferase homolog A

TRM2 tRNA methyltransferase 2 homolog A

Related Diseases

Diseases

Alias

Breast Mucinous Carcinoma

Mucinous Carcinoma Of Breast

Invasive Mucinous Breast Carcinoma

Velocardiofacial Syndrome

Shprintzen Syndrome	VCFS
Chromosome 22q11.2 Deletion Syndrome	Vcf Syndrome
Shprintzen Vcf Syndrome	Vcf-Velocardiofacial Syndrome
Velo-Cardio-Facial Syndrome	Digeorge Syndrome
22q11 Deletion Syndrome	Conotruncal Anomaly Face Syndrome

Chromosome 22q11.2 Deletion Syndrome, Distal

22q11.2 Deletion Syndrome	Autosomal Dominant Opitz G/Bbb Syndrome
Catch22	Cayler Cardiofacial Syndrome
Conotruncal Anomaly Face Syndrome	Digeorge Syndrome
Sedlackova Syndrome	Shprintzen Syndrome
Velocardiofacial Syndrome	22q11.2 Distal Deletion Syndrome
Distal 22q11.2 Microdeletion Syndrome	22q11.2ds
Vcfs	Velo-Cardio-Facial Syndrome
Distal Chromosome 22q11.2 Deletion Syndrome	Chromosome 22q11.2 Deletion Syndrome Distal
Chromosome 22q11.2 Deletion Syndrome	Deletion 22q11.2 Syndrome
22q11ds	Catch 22
Digeorge Sequence	Microdeletion 22q11.2
Monosomy 22q11	Takao Syndrome
Distal Del(22)(Q11.2)	Distal Monosomy 22q11.2
Catch 22 Syndrome	Chromosome Deletion Syndrome 22q11.2, Distal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15091	TRMT2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRMT2A	MGD	MGI:96270
Felis catus	TRMT2A	VGNC	VGNC:66571
Canis familiaris	TRMT2A	VGNC	VGNC:47858
Macaca mulatta	TRMT2A	VGNC	VGNC:79463
Rattus norvegicus	TRMT2A	RGD	RGD:1310418
Bos taurus	TRMT2A	VGNC	VGNC:36372

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