2. Gene
  3. TAF5L - TATA-box binding protein associated factor 5 like Gene

TAF5L - TATA-box binding protein associated factor 5 like Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PAF65B

Gene ID: 27097 | Gene type: protein coding

About TAF5L

This gene has 4 transcripts (splice variants), 223 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 3.7), fat (RPKM 3.5) and 25 other tissues.

Summary

The product of this gene belongs to the WD-repeat TAF5 family of proteins. This gene encodes a protein that is a component of the PCAF histone acetylase complex. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors to facilitate complex assembly and transcription initiation. The encoded protein is structurally similar to one of the histone-like TAFs, TAF5. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

TAF5L Products(2)

mRNA Protein Name
NM_001025247.2 NP_001020418.1 TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform b
NM_014409.4 NP_055224.1 TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L isoform a

TAF5L Protein Structure

TFIID_NTD2

TFIID_NTD2: WD40 associated region in TFIID subunit, NTD2 domain (56 - 196)

WD40

WD40: WD domain, G-beta repeat (271 - 296)

WD40

WD40: WD domain, G-beta repeat (334 - 370)

WD40

WD40: WD domain, G-beta repeat (380 - 412)

WD40

WD40: WD domain, G-beta repeat (418 - 454)

WD40

WD40: WD domain, G-beta repeat (459 - 496)

WD40

WD40: WD domain, G-beta repeat (502 - 538)

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  • 589 a.a.
Protein Preferred Names Protein Names

TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

PAF65-beta

TAF5L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra TAF5L O75529 FOXO3 Homo sapiens O43524
Pull Down
25609649
Intra TAF5L O75529 TUBB8 Homo sapiens Q3ZCM7
Anti Tag CoIP
33961781
Intra TAF5L O75529 TUBB8 Homo sapiens Q3ZCM7
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Heinz Body Anemias

Heinz Body Anemia

Heinz Body Anemias, Alpha-

HEIBAN

Anemia, Heinz Body

Acquired Heinz Body Anemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14172 TAF5L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TAF5L VGNC VGNC:47084
Mus musculus TAF5L MGD MGI:1919039
Rattus norvegicus TAF5L RGD RGD:1310215
Macaca mulatta TAF5L VGNC VGNC:78148
Felis catus TAF5L VGNC VGNC:65934