SIGLEC8 - sialic acid binding Ig like lectin 8 Gene

Homo sapiens

Also known as SAF2; SIGLEC-8; SIGLEC8L

Gene ID: 27181 | Gene type: protein coding

About SIGLEC8

Cytogenetic location: 19q13.41 Genomic coordinates (GRCh38): 19:51,450,997-51,458,454 (from NCBI)

This gene has 4 transcripts (splice variants), 91 orthologues and 16 paralogues. Broad expression in lymph node (RPKM 2.6), spleen (RPKM 2.6) and 14 other tissues.

Summary

Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MIM 604964), and a motif homologous to one identified in signaling lymphocyte activation molecule (SLAM; MIM 603492) that mediates an association with SLAM-associated protein (SAP; MIM 300490) (summarized by Foussias et al., 2000 [PubMed 11095983]).[supplied by OMIM, May 2010]

SIGLEC8 Products(2)

mRNA	Protein	Name
NM_001363548.1	NP_001350477.1	sialic acid-binding Ig-like lectin 8 isoform 2 precursor
NM_014442.3	NP_055257.2	sialic acid-binding Ig-like lectin 8 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21982860	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGLEC8 Protein Structure

V-set

Ig_2

0
100
200
300
400
499 a.a.

Protein Preferred Names

Protein Names

sialic acid-binding Ig-like lectin 8

CDw329

SIGLEC8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SIGLEC8	Q9NYZ4	TFF1	Homo sapiens	P04155	Protein Array	21982860
Intra	SIGLEC8	Q9NYZ4	TFF1	Homo sapiens	P04155	SPR	21982860

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIGLEC8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71312	Siglec-8 Protein, Human (HEK293, Fc)	Q9P0M4/NP_037410.1 (M17-A363)	≥95%
HY-P71313	Siglec-8 Protein, Human (HEK293, His)	Q9P0M4/NP_037410.1 (M17-A363)	≥95%
HY-P78204	Siglec-8 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9P0M4/NP_037410.1 (M17-A363)	≥95%
HY-P78513	Siglec-8 Protein, Human (HEK293, His-Avi)	Q9P0M4/NP_037410.1 (M17-A363)	≥95%

Related Diseases

Diseases

Alias

Eosinophilic Gastritis

Eosinophilic Enteropathy

Chronic Inducible Urticaria

Indolent Systemic Mastocytosis

Ism

Duodenitis

Hemorrhagic Duodenitis	Acute Enteritis Of The Mouse Intestinal Tract
Nonspecific Duodenitis	Inflammation Of Duodenum
Dodecadactylitis	Duodenal Inflammation
Peptic Duodenitis

Eosinophilic Gastroenteritis

Eosinophilic Enteritis	Ege
Eosinophilic Gastroenterocolitis	Eosinophilic Esophagitis
Eosinophilic Gastritis	Eosinophilic Gastroenteropathy
Gastroenteritis, Eosinophilic	Eosinophilic Enteropathy

Congenital Disorder Of Glycosylation, Type Iic

CDG2C	Congenital Disorder Of Glycosylation Type Iic
Leukocyte Adhesion Deficiency Type Ii	Cdg Iic
Cdgiic	Rambam-Hasharon Syndrome
Leukocyte Adhesion Deficiency, Type Ii	Lad2
Leukocyte Adhesion Deficiency 2	Cdg-Iic
Congenital Disorder Of Glycosylation, Type 2c	Rhs
Cdg Syndrome Type Iic	Lad-Ii
Rambam Hasharon Syndrome	Congenital Disorder Of Glycosylation 2c
Glycosylation, Congenital Disorder Of, Type Iic

Chronic Spontaneous Urticaria

Chronic Idiopathic Urticaria

Esophagitis, Eosinophilic, 1

Eosinophilic Esophagitis	EOE1
Esophagitis, Eosinophilic	Ee

Chronic Eosinophilic Leukemia

Pdgfra-Associated Chronic Eosinophilic Leukemia

Chronic Frontal Sinusitis

Dermatographia

Dermatographic Urticaria	Dermographism
Symptomatic Dermographism	Urticaria Factitia
Factitious Urticaria	Dermatographism

Aggressive Systemic Mastocytosis

Asm	Lymphadenopathic Mastocytosis With Eosinophilia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99371	Lirentelimab	Inducer	99.91%	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12906	SIGLEC8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SIGLEC8	RGD	RGD:1563073
Mus musculus	SIGLEC8	NCBI
Others	SIGLEC8	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.