RNF115 - ring finger protein 115 Gene

Homo sapiens

Also known as BCA2; ZFP364; ZNF364; RABRING7

Gene ID: 27246 | Gene type: protein coding

About RNF115

Cytogenetic location: 1q21.1 Genomic coordinates (GRCh38): 1:145,738,868-145,824,095 (from NCBI)

This gene has 2 transcripts (splice variants), 256 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 16.1), fat (RPKM 8.2) and 25 other tissues.

Summary

Enables ubiquitin-protein transferase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway; protein autoubiquitination; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

RNF115 Products(1)

mRNA	Protein	Name
NM_014455.4	NP_055270.1	E3 ubiquitin-protein ligase RNF115

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16925951	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	35343654	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	18819927	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of epidermal growth factor receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23418353	GOA
involved in negative regulation of toll-like receptor signaling pathway	IDA IDA: Inferred from direct assay	35343654	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	35343654	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	16288031	GOA
involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway	IMP IMP: Inferred from mutant phenotype	23418353	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	35343654	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNF115 Protein Structure

zinc_ribbon_9

zf-RING_2

0
100
200
304 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF115

RING-type E3 ubiquitin transferase RNF115

RNF115 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RNF115	Q9Y4L5	UBE2E2	Homo sapiens	Q96LR5	Y2H Array	32296183
Intra	RNF115	Q9Y4L5	UBE2E2	Homo sapiens	Q96LR5	Y2H Prey Pooling	32296183
Intra	RNF115	Q9Y4L5	UBE2D2	Homo sapiens	P62837	Y2H Array	19690564
Intra	RNF115	Q9Y4L5	UBE2D3	Homo sapiens	P61077	Y2H Prey Pooling	25416956
Intra	RNF115	Q9Y4L5	UBE2D3	Homo sapiens	P61077	Validated Y2H	25416956
Intra	RNF115	Q9Y4L5	VCP	Homo sapiens	P55072	Validated Y2H	32814053
Intra	RNF115	Q9Y4L5	VCP	Homo sapiens	P55072	Y2H Array	32814053
Intra	RNF115	Q9Y4L5	VCP	Homo sapiens	P55072	Y2H Pooling	32814053
Intra	RNF115	Q9Y4L5	MDM4	Homo sapiens	O15151	Y2H Prey Pooling	25416956
Intra	RNF115	Q9Y4L5	MDM4	Homo sapiens	O15151	Y2H Array	25416956
Intra	RNF115	Q9Y4L5	DAZAP2	Homo sapiens	Q15038	Validated Y2H	25416956
Intra	RNF115	Q9Y4L5	DAZAP2	Homo sapiens	Q15038	Y2H Array	25416956
Intra	RNF115	Q9Y4L5	DAZAP2	Homo sapiens	Q15038	Y2H	21516116
Intra	RNF115	Q9Y4L5	UBE2D1	Homo sapiens	P51668	Y2H Array	25416956
Intra	RNF115	Q9Y4L5	UBE2D1	Homo sapiens	P51668	Y2H Prey Pooling	25416956
Intra	RNF115	Q9Y4L5	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	31515488
Intra	RNF115	Q9Y4L5	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

RNF115 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81834	ZNF364 Antibody (YA1579)	WB	Human, Rat

Related Diseases

Diseases

Alias

Brachydactyly, Type A3

Brachydactyly Type A3	BDA3
Brachydactyly-Clinodactyly	Brachymesophalangy V
Brachymesophalangy 5	Brachydactyly Clinodactyly

Cataract 4, Multiple Types

Cataract 4 Multiple Types	CTRCT4
Cca3	Pcc
Aculeiform Cataract	Cataract 4, Multiple Types, With Or Without Microcornea
Cataract, Crystalline Aculeiform	Caca
Cataract, Congenital, Cerulean Type, 3	Congenital Cataract Cerulean Type 3
Cataract Congenital Dominant Non Nuclear	Ccp
Cataract, Nonnuclear Polymorphic Congenital	Cataract, Punctate, Progressive Juvenile-Onset
Cataract 4 Multiple Types With Or Without Microcornea	Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract
Cataract, Polymorphic Congenital	Congenital Cataract Blue Dot Type 3
Congenital Non-Nuclear Polymorphic Cataract	Crystalline Aculeiform Cataract
Punctate, Progressive Juvenile-Onset, Cataract	Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant

Spastic Hemiplegia

Spastic Hemiplegic Cerebral Palsy	Hemiplegic Cerebral Palsy
Congenital Hemiplegia	Hemiplegic Infantile Cerebral Palsy
Cerebral Palsy Spastic Hemiplegic	Spastic Hemiplegia Cerebral Palsy
Hemiplegia, Spastic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12040	RNF115 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RNF115	RGD	RGD:1305315
Canis familiaris	RNF115	VGNC	VGNC:45624
Macaca mulatta	RNF115	VGNC	VGNC:76762
Bos taurus	RNF115	VGNC	VGNC:34013
Mus musculus	RNF115	MGD	MGI:1915095
Felis catus	RNF115	VGNC	VGNC:80343

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