2. Gene
  3. UBE2D3 - ubiquitin conjugating enzyme E2 D3 Gene

UBE2D3 - ubiquitin conjugating enzyme E2 D3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as UBC4/5; UBCH5C; E2(17)KB3

Gene ID: 7323 | Gene type: protein coding

About UBE2D3

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:102,794,383-102,868,895 (from NCBI)

This gene has 33 transcripts (splice variants), 258 orthologues and 12 paralogues. Ubiquitous expression in bone marrow (RPKM 59.8), thyroid (RPKM 40.1) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein Ligase. [provided by RefSeq, Jan 2017]

UBE2D3 Products(10)

mRNA Protein Name
NM_001300795.2 NP_001287724.1 ubiquitin-conjugating enzyme E2 D3 isoform 4
NM_003340.6 NP_003331.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181886.3 NP_871615.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181887.3 NP_871616.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181888.3 NP_871617.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181889.2 NP_871618.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181890.3 NP_871619.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181891.3 NP_871620.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181892.4 NP_871621.1 ubiquitin-conjugating enzyme E2 D3 isoform 2
NM_181893.3 NP_871622.1 ubiquitin-conjugating enzyme E2 D3 isoform 3

UBE2D3 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (5 - 141)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 D3

(E3-independent) E2 ubiquitin-conjugating enzyme D3

UBE2D3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
UBE2D3 P61077 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
32296183
Intra
UBE2D3 P61077 MID2 Homo sapiens Q9UJV3-2
Validated Y2H
32296183
Intra
UBE2D3 P61077 MID2 Homo sapiens Q9UJV3-2
Y2H Array
32296183
Intra
UBE2D3 P61077 OTUB1 Homo sapiens Q96FW1
Validated Y2H
32296183
Intra
UBE2D3 P61077 OTUB1 Homo sapiens Q96FW1
Y2H Array
32296183
Intra
UBE2D3 P61077 OTUB1 Homo sapiens Q96FW1
Y2H Prey Pooling
25416956
Intra
UBE2D3 P61077 OTUB1 Homo sapiens Q96FW1
Y2H Prey Pooling
32296183
Intra
UBE2D3 P61077 OTUB1 Homo sapiens Q96FW1
Anti Tag CoIP
22124327
Cross
UBE2D3 P61077 sspH2 Salmonella typhimurium P0CE12
NMR
20133640
Cross
UBE2D3 P61077 sspH2 Salmonella typhimurium P0CE12
Ubiquitinase Assay
20133640
Intra
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9-2
Validated Y2H
32296183
Intra
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9-2
Y2H Array
32296183
Intra
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9-2
Y2H Prey Pooling
32296183
Intra
UBE2D3 P61077 RNF111 Homo sapiens Q6ZNA4
Y2H Array
19690564
Intra
UBE2D3 P61077 RNF111 Homo sapiens Q6ZNA4
Validated Y2H
25416956
Intra
UBE2D3 P61077 RNF25 Homo sapiens Q96BH1
Y2H Prey Pooling
32296183
Intra
UBE2D3 P61077 RNF25 Homo sapiens Q96BH1
Validated Y2H
32296183
Intra
UBE2D3 P61077 RNF25 Homo sapiens Q96BH1
Y2H Array
32296183
Intra
UBE2D3 P61077 RNF115 Homo sapiens Q9Y4L5
Validated Y2H
32296183
Intra
UBE2D3 P61077 RNF115 Homo sapiens Q9Y4L5
Y2H Prey Pooling
32296183
Intra
UBE2D3 P61077 RNF115 Homo sapiens Q9Y4L5
Y2H Array
32296183
Intra
UBE2D3 P61077 RNF115 Homo sapiens Q9Y4L5
Y2H Array
25416956
Intra
UBE2D3 P61077 RNF115 Homo sapiens Q9Y4L5
Y2H Array
19690564
Intra
UBE2D3 P61077 ZNRF1 Homo sapiens Q8ND25
Y2H Array
19549727
Intra
UBE2D3 P61077 ZNRF1 Homo sapiens Q8ND25
Y2H
19549727
Intra
UBE2D3 P61077 DTX3 Homo sapiens Q8N9I9
Validated Y2H
32296183
Intra
UBE2D3 P61077 DTX3 Homo sapiens Q8N9I9
Y2H Array
32296183
Intra
UBE2D3 P61077 DTX3 Homo sapiens Q8N9I9
Y2H Prey Pooling
32296183
Intra
UBE2D3 P61077 DTX3 Homo sapiens Q8N9I9
Y2H Array
19549727
Intra
UBE2D3 P61077 MID1 Homo sapiens O15344
Validated Y2H
25416956
Intra
UBE2D3 P61077 MID1 Homo sapiens O15344
Y2H Array
32296183
Intra
UBE2D3 P61077 MID1 Homo sapiens O15344
Y2H Prey Pooling
25416956
Intra
UBE2D3 P61077 MID1 Homo sapiens O15344
Y2H Prey Pooling
32296183
Intra
UBE2D3 P61077 MID1 Homo sapiens O15344
Y2H Array
31515488
Intra
UBE2D3 P61077 RNF5 Homo sapiens Q99942
Y2H Prey Pooling
32296183
Intra
UBE2D3 P61077 RNF5 Homo sapiens Q99942
Validated Y2H
32296183
Intra
UBE2D3 P61077 RNF5 Homo sapiens Q99942
Y2H Array
32296183
Intra
UBE2D3 P61077 RNF126 Homo sapiens Q9BV68
Y2H Array
31515488
Intra
UBE2D3 P61077 RNF126 Homo sapiens Q9BV68
Y2H Array
19549727
Intra
UBE2D3 P61077 RNF126 Homo sapiens Q9BV68
Y2H
19549727
Intra
UBE2D3 P61077 RNF126 Homo sapiens Q9BV68
Y2H Pooling
16189514
Intra
UBE2D3 P61077 RNF11 Homo sapiens Q9Y3C5
Enzymatic Study
19549727
Intra
UBE2D3 P61077 RNF11 Homo sapiens Q9Y3C5
Y2H Array
19549727
Intra
UBE2D3 P61077 XIAP Homo sapiens P98170
Enzymatic Study
19549727
Intra
UBE2D3 P61077 XIAP Homo sapiens P98170
Y2H Array
19549727
Intra
UBE2D3 P61077 TRIM62 Homo sapiens Q9BVG3
Y2H Prey Pooling
32296183
Intra
UBE2D3 P61077 TRIM62 Homo sapiens Q9BVG3
Y2H Array
32296183
Intra
UBE2D3 P61077 TRIM62 Homo sapiens Q9BVG3
Validated Y2H
32296183
Intra
UBE2D3 P61077 RNF2 Homo sapiens Q99496
Y2H Array
32296183
Intra
UBE2D3 P61077 RNF2 Homo sapiens Q99496
Y2H Prey Pooling
32296183
Intra
UBE2D3 P61077 RNF2 Homo sapiens Q99496
Validated Y2H
32296183
Intra
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9
Validated Y2H
25416956
Intra
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9
Y2H Pooling
16189514
Intra
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9
Y2H Array
19549727
Intra
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9
Y2H Array
31515488
Intra
UBE2D3 P61077 TRIM39 Homo sapiens Q9HCM9
Y2H Prey Pooling
25416956
Intra
UBE2D3 P61077 DTX2 Homo sapiens Q86UW9
Y2H Array
32296183
Intra
UBE2D3 P61077 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
25416956
Intra
UBE2D3 P61077 DTX2 Homo sapiens Q86UW9
Y2H Prey Pooling
32296183
Intra
UBE2D3 P61077 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
Intra
UBE2D3 P61077 UBTD1 Homo sapiens Q9HAC8
Y2H Array
32296183
Intra
UBE2D3 P61077 UBTD1 Homo sapiens Q9HAC8
Y2H Prey Pooling
32296183
Intra
UBE2D3 P61077 UBTD1 Homo sapiens Q9HAC8
Validated Y2H
32296183
Cross
UBE2D3 P61077 Dapk3 Mus musculus O54784
Anti Tag CoIP
18515077
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2D3 Proteins

Cat. No. Product Name Accession Purity
HY-P70998 UBE2D3 Protein, Human AAH66917 (M1-M147) ≥95%

Related Diseases

Diseases Alias
Limb-Girdle Muscular Dystrophy

Lgmd

Limb Girdle Muscular Dystrophy

Muscular Dystrophies, Limb-Girdle

Erb'S Muscular Dystrophy

Leyden-Mbius Muscular Dystrophy

Limb-Girdle Syndrome

Myopathic Limb-Girdle Syndrome

Limb Girdle

Muscular Dystrophy Limb-Girdle

Dystrophy, Muscular, Limb-Girdle

Lgmd - [Limb-Girdle Muscular Dystrophy]

Limb Girdle Muscle Dystrophy

Limb-Girdle Myopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15341 UBE2D3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus UBE2D3 RGD RGD:619912
Mus musculus UBE2D3 MGD MGI:1913355
Felis catus UBE2D3 VGNC VGNC:80097
Bos taurus UBE2D3 VGNC VGNC:107251
Macaca mulatta UBE2D3 VGNC VGNC:82265
Others UBE2D3 NCBI