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  2. UBE2D3 - ubiquitin conjugating enzyme E2 D3 Gene

UBE2D3 - ubiquitin conjugating enzyme E2 D3 Gene

Homo sapiens

Also known as UBC4/5; UBCH5C; E2(17)KB3

Gene ID: 7323 | Gene type: protein coding

About UBE2D3

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:102,794,383-102,868,895 (from NCBI)

This gene has 33 transcripts (splice variants), 258 orthologues and 12 paralogues. Ubiquitous expression in bone marrow (RPKM 59.8), thyroid (RPKM 40.1) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein Ligase. [provided by RefSeq, Jan 2017]

UBE2D3 Products(10)

mRNA Protein Name
NM_001300795.2 NP_001287724.1 ubiquitin-conjugating enzyme E2 D3 isoform 4
NM_003340.6 NP_003331.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181886.3 NP_871615.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181887.3 NP_871616.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181888.3 NP_871617.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181889.2 NP_871618.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181890.3 NP_871619.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181891.3 NP_871620.1 ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181892.4 NP_871621.1 ubiquitin-conjugating enzyme E2 D3 isoform 2
NM_181893.3 NP_871622.1 ubiquitin-conjugating enzyme E2 D3 isoform 3

UBE2D3 Protein Structure

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (5 - 141)

  • 0
  • 100
  • 147 a.a.
Protein Preferred Names Protein Names

ubiquitin-conjugating enzyme E2 D3

(E3-independent) E2 ubiquitin-conjugating enzyme D3

Recombinant UBE2D3 Proteins

Cat. No. Product Name Accession Purity
HY-P70998 UBE2D3 Protein, Human AAH66917 (M1-M147) ≥95%

Related Diseases

Diseases Alias
Limb-Girdle Muscular Dystrophy

Lgmd

Limb Girdle Muscular Dystrophy

Muscular Dystrophies, Limb-Girdle

Erb'S Muscular Dystrophy

Leyden-Mbius Muscular Dystrophy

Limb-Girdle Syndrome

Myopathic Limb-Girdle Syndrome

Limb Girdle

Muscular Dystrophy Limb-Girdle

Dystrophy, Muscular, Limb-Girdle

Lgmd - [Limb-Girdle Muscular Dystrophy]

Limb Girdle Muscle Dystrophy

Limb-Girdle Myopathy

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus UBE2D3 RGD RGD:619912
Mus musculus UBE2D3 MGD MGI:1913355
Felis catus UBE2D3 VGNC VGNC:80097
Bos taurus UBE2D3 VGNC VGNC:107251
Macaca mulatta UBE2D3 VGNC VGNC:82265
Others UBE2D3 NCBI