UBE2D3 - ubiquitin conjugating enzyme E2 D3 Gene

Homo sapiens

Also known as UBC4/5; UBCH5C; E2(17)KB3

Gene ID: 7323 | Gene type: protein coding

About UBE2D3

Cytogenetic location: 4q24 Genomic coordinates (GRCh38): 4:102,794,383-102,868,895 (from NCBI)

This gene has 33 transcripts (splice variants), 258 orthologues and 12 paralogues. Ubiquitous expression in bone marrow (RPKM 59.8), thyroid (RPKM 40.1) and 25 other tissues.

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes, or E1s, ubiquitin-conjugating Enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein Ligase. [provided by RefSeq, Jan 2017]

UBE2D3 Products(10)

mRNA	Protein	Name
NM_001300795.2	NP_001287724.1	ubiquitin-conjugating enzyme E2 D3 isoform 4
NM_003340.6	NP_003331.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181886.3	NP_871615.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181887.3	NP_871616.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181888.3	NP_871617.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181889.2	NP_871618.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181890.3	NP_871619.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181891.3	NP_871620.1	ubiquitin-conjugating enzyme E2 D3 isoform 1
NM_181892.4	NP_871621.1	ubiquitin-conjugating enzyme E2 D3 isoform 2
NM_181893.3	NP_871622.1	ubiquitin-conjugating enzyme E2 D3 isoform 3

UBE2D3 Protein Structure

UQ_con

0
100
147 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 D3

(E3-independent) E2 ubiquitin-conjugating enzyme D3

Recombinant UBE2D3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70998	UBE2D3 Protein, Human	AAH66917 (M1-M147)	≥95%

Related Diseases

Diseases

Alias

Limb-Girdle Muscular Dystrophy

Lgmd	Limb Girdle Muscular Dystrophy
Muscular Dystrophies, Limb-Girdle	Erb'S Muscular Dystrophy
Leyden-Mbius Muscular Dystrophy	Limb-Girdle Syndrome
Myopathic Limb-Girdle Syndrome	Limb Girdle
Muscular Dystrophy Limb-Girdle	Dystrophy, Muscular, Limb-Girdle
Lgmd - [Limb-Girdle Muscular Dystrophy]	Limb Girdle Muscle Dystrophy
Limb-Girdle Myopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15341	UBE2D3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	UBE2D3	RGD	RGD:619912
Mus musculus	UBE2D3	MGD	MGI:1913355
Felis catus	UBE2D3	VGNC	VGNC:80097
Bos taurus	UBE2D3	VGNC	VGNC:107251
Macaca mulatta	UBE2D3	VGNC	VGNC:82265
Others	UBE2D3	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.