GCLM - glutamate-cysteine ligase modifier subunit Gene

Homo sapiens

Also known as GLCLR

Gene ID: 2730 | Gene type: protein coding

About GCLM

Cytogenetic location: 1p22.1 Genomic coordinates (GRCh38): 1:93,885,199-93,909,430 (from NCBI)

This gene has 4 transcripts (splice variants), 204 orthologues and is associated with 1 phenotype. Ubiquitous expression in liver (RPKM 13.0), thyroid (RPKM 9.9) and 24 other tissues.

Summary

Glutamate-cysteine Ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting Enzyme of glutathione synthesis. The Enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

GCLM Products(2)

mRNA	Protein	Name
NM_001308253.2	NP_001295182.1	glutamate--cysteine ligase regulatory subunit isoform 2
NM_002061.4	NP_002052.1	glutamate--cysteine ligase regulatory subunit isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to glutamate-cysteine ligase activity	IMP IMP: Inferred from mutant phenotype	16183645	GOA
enables glutamate-cysteine ligase catalytic subunit binding	IPI IPI: Inferred from physical interaction	9675072	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9675072	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood vessel diameter maintenance	IMP IMP: Inferred from mutant phenotype	12975258	GOA
involved in glutamate metabolic process	IDA IDA: Inferred from direct assay	9841880	GOA
involved in glutathione biosynthetic process	IDA IDA: Inferred from direct assay	9675072	GOA
involved in glutathione biosynthetic process	IMP IMP: Inferred from mutant phenotype	12081989	GOA
involved in response to oxidative stress	IDA IDA: Inferred from direct assay	10395918	GOA
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	9895302	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of glutamate-cysteine ligase complex	IDA IDA: Inferred from direct assay	9675072	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GCLM Protein Structure

Aldo_ket_red

0
100
200
274 a.a.

Protein Preferred Names

Protein Names

glutamate--cysteine ligase regulatory subunit

GCS light chain

GCLM Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GCLM	P48507	GCLC	Homo sapiens	P48506	Anti Tag CoIP	33961781
Intra	GCLM	P48507	GCLC	Homo sapiens	P48506	Chromatography	9675072
Intra	GCLM	P48507	OSGIN1	Homo sapiens	Q9UJX0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

GCLM Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81662	GCLM Antibody (YA1407)	WB, IHC-P, ICC/IF, IP, FC	Human, Mouse, Rat

Related Diseases

Diseases

Alias

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

Parkinson Disease 4, Autosomal Dominant

Autosomal Dominant Parkinson Disease 4	PARK4
Parkinson Disease 4, Autosomal Dominant Lewy Body	Parkinson Disease 4
Parkinson'S Disease 4	Autosomal Dominant Lewy Body Parkinson Disease 4
Autosomal Dominant Parkinson'S Disease 4	Parkinson Disease 4 Autosomal Dominant Lewy Body
Parkinson Disease Autosomal Dominant 4	Parkinson Disease Familial Type 4
Parkinson Disease, Type 4

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121523	MIND4-17	Activator	99.93%	Unkown
HY-147517	Keap1-Nrf2-IN-9	Inhibitor	98.52%	Unkown
HY-RS05334	GCLM Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GCLM	VGNC	VGNC:41148
Rattus norvegicus	GCLM	RGD	RGD:619871
Bos taurus	GCLM	VGNC	VGNC:29290
Felis catus	GCLM	VGNC	VGNC:80218
Macaca mulatta	GCLM	VGNC	VGNC:72924
Mus musculus	GCLM	MGD	MGI:104995

Name
Email *

	Sorry, but the email address you supplied was invalid.