OSGIN1 - oxidative stress induced growth inhibitor 1 Gene

Homo sapiens

Also known as BDGI; OKL38

Gene ID: 29948 | Gene type: protein coding

About OSGIN1

Cytogenetic location: 16q23.3 Genomic coordinates (GRCh38): 16:83,953,240-83,966,332 (from NCBI)

This gene has 8 transcripts (splice variants), 124 orthologues and 1 paralogue. Broad expression in liver (RPKM 32.8), duodenum (RPKM 12.4) and 14 other tissues.

Summary

This gene encodes an oxidative stress response protein that regulates cell death. Expression of the gene is regulated by p53 and is induced by DNA damage. The protein regulates Apoptosis by inducing cytochrome c release from mitochondria. It also appears to be a key regulator of both inflammatory and anti-inflammatory molecules. The loss of this protein correlates with uncontrolled cell growth and tumor formation. Naturally occurring read-through transcription exists between this gene and the neighboring upstream malonyl-CoA decarboxylase (MLYCD) gene, but the read-through transcripts are unlikely to produce a protein product. [provided by RefSeq, Aug 2011]

OSGIN1 Products(1)

mRNA	Protein	Name
NM_182981.3	NP_892026.1	oxidative stress-induced growth inhibitor 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables growth factor activity	IDA IDA: Inferred from direct assay	11459809	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cell growth	IDA IDA: Inferred from direct assay	11459809	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OSGIN1 Protein Structure

Pyr_redox_3

0
100
200
300
400
500
560 a.a.

Protein Preferred Names

Protein Names

oxidative stress-induced growth inhibitor 1

BMSC-derived growth inhibitor

OSGIN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OSGIN1	Q9UJX0	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	POLDIP3	Homo sapiens	Q8WUT1	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	POLDIP3	Homo sapiens	Q8WUT1	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	GCLM	Homo sapiens	P48507	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	GCLM	Homo sapiens	P48507	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	TLE5	Homo sapiens	Q08117-2	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	TLE5	Homo sapiens	Q08117-2	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	PDE4A	Homo sapiens	P27815-4	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	PDE4A	Homo sapiens	P27815-4	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	PDE4C	Homo sapiens	Q08493-2	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	PDE4C	Homo sapiens	Q08493-2	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	ZBTB42	Homo sapiens	B2RXF5	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	ZBTB42	Homo sapiens	B2RXF5	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	ZC2HC1C	Homo sapiens	Q53FD0-2	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	MEI4	Homo sapiens	A8MW99	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	MEI4	Homo sapiens	A8MW99	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	CENPN	Homo sapiens	Q96H22-3	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	CENPN	Homo sapiens	Q96H22-3	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	MEIS2	Homo sapiens	O14770	Y2H Prey Pooling	25416956
Intra	OSGIN1	Q9UJX0	ZKSCAN4	Homo sapiens	Q969J2	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	ZKSCAN4	Homo sapiens	Q969J2	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	MEOX1	Homo sapiens	P50221	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	MEOX1	Homo sapiens	P50221	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	KRT75	Homo sapiens	O95678	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	PAX5	Homo sapiens	Q02548	Validated Y2H	32296183
Intra	OSGIN1	Q9UJX0	PAX5	Homo sapiens	Q02548	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	PAX5	Homo sapiens	Q02548	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	OSGIN1	Q9UJX0	POLR2G	Homo sapiens	P62487	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	POLR2G	Homo sapiens	P62487	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	DECR2	Homo sapiens	Q9NUI1	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	DECR2	Homo sapiens	Q9NUI1	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	DNAJA3	Homo sapiens	Q96EY1-2	Y2H Array	25416956
Intra	OSGIN1	Q9UJX0	SAXO1	Homo sapiens	Q8IYX7	Y2H Array	25416956
Intra	OSGIN1	Q9UJX0	TCF4	Homo sapiens	P15884	Y2H Prey Pooling	25416956
Intra	OSGIN1	Q9UJX0	TCF4	Homo sapiens	P15884	Y2H Array	25416956
Intra	OSGIN1	Q9UJX0	CAPN3	Homo sapiens	P20807	Y2H Prey Pooling	25416956
Intra	OSGIN1	Q9UJX0	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	INCA1	Homo sapiens	Q0VD86	Y2H Array	25416956
Intra	OSGIN1	Q9UJX0	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	25416956
Intra	OSGIN1	Q9UJX0	BCAR3	Homo sapiens	O75815	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	BCAR3	Homo sapiens	O75815	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	BTBD2	Homo sapiens	Q9BX70	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	BTBD2	Homo sapiens	Q9BX70	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	KATNBL1	Homo sapiens	Q9H079	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	KATNBL1	Homo sapiens	Q9H079	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	TLE5	Homo sapiens	Q08117	Validated Y2H	25416956
Intra	OSGIN1	Q9UJX0	TLE5	Homo sapiens	Q08117	Y2H Array	25416956
Intra	OSGIN1	Q9UJX0	TCF12	Homo sapiens	Q99081	Y2H Prey Pooling	25416956
Intra	OSGIN1	Q9UJX0	LNX1	Homo sapiens	Q8TBB1	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	LNX1	Homo sapiens	Q8TBB1	Y2H Array	25416956
Intra	OSGIN1	Q9UJX0	LNX1	Homo sapiens	Q8TBB1	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	SORBS3	Homo sapiens	O60504	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	31515488
Intra	OSGIN1	Q9UJX0	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	25416956
Intra	OSGIN1	Q9UJX0	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	25416956
Intra	OSGIN1	Q9UJX0	CRX	Homo sapiens	O43186	Validated Y2H	25416956
Intra	OSGIN1	Q9UJX0	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956
Intra	OSGIN1	Q9UJX0	ARNT2	Homo sapiens	Q9HBZ2	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	ARNT2	Homo sapiens	Q9HBZ2	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	IKBKG	Homo sapiens	Q9Y6K9	Validated Y2H	32296183
Intra	OSGIN1	Q9UJX0	IKBKG	Homo sapiens	Q9Y6K9	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	IKBKG	Homo sapiens	Q9Y6K9	Y2H Prey Pooling	32296183
Intra	OSGIN1	Q9UJX0	MTERF4	Homo sapiens	Q7Z6M4	Y2H Array	32296183
Intra	OSGIN1	Q9UJX0	MTERF4	Homo sapiens	Q7Z6M4	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09849	OSGIN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	OSGIN1	RGD	RGD:620679
Felis catus	OSGIN1	VGNC	VGNC:63988
Macaca mulatta	OSGIN1	VGNC	VGNC:75700
Bos taurus	OSGIN1	VGNC	VGNC:32472
Mus musculus	OSGIN1	MGD	MGI:1919089

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