UBE2S - ubiquitin conjugating enzyme E2 S Gene

Homo sapiens

Also known as EPF5; E2EPF; E2-EPF

Gene ID: 27338 | Gene type: protein coding

About UBE2S

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,399,745-55,407,788 (from NCBI)

This gene has 4 transcripts (splice variants), 197 orthologues and 24 paralogues. Broad expression in testis (RPKM 34.2), bone marrow (RPKM 25.4) and 21 other tissues.

Summary

This gene encodes a member of the ubiquitin-conjugating Enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]

UBE2S Products(1)

mRNA	Protein	Name
NM_014501.3	NP_055316.2	ubiquitin-conjugating enzyme E2 S

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables anaphase-promoting complex binding	IPI IPI: Inferred from physical interaction	23708001	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23708001	GOA
enables ubiquitin conjugating enzyme activity	IDA IDA: Inferred from direct assay	21376237	GOA
contributes to ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	19820702	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	20061386	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in anaphase-promoting complex-dependent catabolic process	IDA IDA: Inferred from direct assay	19820702	GOA
involved in exit from mitosis	IDA IDA: Inferred from direct assay	19820702	GOA
involved in exit from mitosis	IMP IMP: Inferred from mutant phenotype	19822757	GOA
involved in free ubiquitin chain polymerization	IDA IDA: Inferred from direct assay	19822757	GOA
involved in positive regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	19820702	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	27910872	GOA
acts upstream of or within protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	21376237	GOA
involved in protein K11-linked ubiquitination	IDA IDA: Inferred from direct assay	19822757	GOA
involved in protein K27-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA
involved in protein K29-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA
involved in protein K6-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	20061386	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of anaphase-promoting complex	IDA IDA: Inferred from direct assay	19822757	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBE2S Protein Structure

UQ_con

0
100
200
222 a.a.

Protein Preferred Names

Protein Names

ubiquitin-conjugating enzyme E2 S

E2 ubiquitin-conjugating enzyme S

UBE2S Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	UBE2S	Q16763	GNB2	Homo sapiens	P62879	Validated Y2H	32814053
Intra	UBE2S	Q16763	GNB2	Homo sapiens	P62879	Y2H Array	32814053
Intra	UBE2S	Q16763	GNB2	Homo sapiens	P62879	Y2H Pooling	32814053
Intra	UBE2S	Q16763	ANAPC2	Homo sapiens	Q9UJX6	Pull Down	23708001

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant UBE2S Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71408	UBE2S Protein, Human (GST)	Q16763 (M1-L222)	≥95%

Related Diseases

Diseases

Alias

Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements, And Impaired Language

Chromosome 5q14.3 Deletion Syndrome	5q14.3 Microdeletion Syndrome
Mental Retardation, Autosomal Dominant 20	NEDHSIL
Autosomal Dominant Mental Retardation 20	Mrd20
Del(5)(Q14.3)	Monosomy 5q14.3
Intellectual Disability, Autosomal Dominant 20	Mental Retardation, Autosomal Dominant 20, Formerly
Mrd20, Formerly	Mental Retardation, Stereotypic Movements, Epilepsy, And/Or Cerebral Malformations
5q14.3 Deletion Syndrome	Autosomal Dominant Intellectual Disability 20
Mental Retardation, Autosomal Dominant, Type 20

Liddle Syndrome 1

Liddle Syndrome	Pseudoaldosteronism
Liddle'S Syndrome	LIDLS1
Lidls	Pseudohyperaldosteronism
Pseudoprimary Hyperaldosteronism	Pseudohyperaldosteronism Type 1
Liddles Syndrome

Juvenile-Onset Parkinson'S Disease

Juvenile-Onset Parkinson Disease

Uterine Adnexa Cancer

Nephrolithiasis/Osteoporosis, Hypophosphatemic, 1

Hypophosphatemic Nephrolithiasis/Osteoporosis 1	NPHLOP1
Nephrolithiasis-Osteoporosis, Hypophosphatemic, 1	Nephrolithiasis/Osteoporosis, Hypophosphatemic, Type 1

Cortical Dysplasia, Complex, With Other Brain Malformations 6

Complex Cortical Dysplasia With Other Brain Malformations 6	CDCBM6
Cdcbm56	Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 6

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15361	UBE2S Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	UBE2S	VGNC	VGNC:48065
Macaca mulatta	UBE2S	VGNC	VGNC:79099
Felis catus	UBE2S	VGNC	VGNC:107073
Bos taurus	UBE2S	VGNC	VGNC:36595
Rattus norvegicus	UBE2S	RGD	RGD:1564746
Mus musculus	UBE2S	MGD	MGI:1925141
Others	UBE2S	NCBI

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