APOBEC3C - apolipoprotein B mRNA editing enzyme catalytic subunit 3C Gene

Homo sapiens

Also known as A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3

Gene ID: 27350 | Gene type: protein coding

About APOBEC3C

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,014,257-39,020,352 (from NCBI)

This gene has 2 transcripts (splice variants), 55 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 33.1), testis (RPKM 26.8) and 24 other tissues.

Summary

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing Enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]

APOBEC3C Products(1)

mRNA	Protein	Name
NM_014508.3	NP_055323.2	DNA dC->dU-editing enzyme APOBEC-3C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22915799	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in clearance of foreign intracellular DNA	IDA IDA: Inferred from direct assay	20062055	GOA
involved in cytidine deamination	IDA IDA: Inferred from direct assay	21632763	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	21632763	GOA
involved in positive regulation of gene expression via chromosomal CpG island demethylation	IDA IDA: Inferred from direct assay	21496894	GOA
involved in retrotransposon silencing	IDA IDA: Inferred from direct assay	16527742	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21835787	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21835787	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC3C Protein Structure

APOBEC_N

0
100
190 a.a.

Protein Preferred Names

Protein Names

DNA dC->dU-editing enzyme APOBEC-3C

apolipoprotein B editing enzyme catalytic polypeptide-like 3C

APOBEC3C Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	APOBEC3C	Q9NRW3	CHTOP	Homo sapiens	Q9Y3Y2-3	Validated Y2H	32296183
Intra	APOBEC3C	Q9NRW3	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Prey Pooling	32296183
Intra	APOBEC3C	Q9NRW3	CHTOP	Homo sapiens	Q9Y3Y2-3	Y2H Array	32296183
Intra	APOBEC3C	Q9NRW3	ZNF48	Homo sapiens	Q96MX3	Anti Tag CoIP	33961781
Intra	APOBEC3C	Q9NRW3	PRR3	Homo sapiens	P79522	Y2H Prey Pooling	32296183
Intra	APOBEC3C	Q9NRW3	PRR3	Homo sapiens	P79522	Y2H Array	32296183
Intra	APOBEC3C	Q9NRW3	TRIB3	Homo sapiens	Q96RU7	Y2H Array	32296183
Intra	APOBEC3C	Q9NRW3	TRIB3	Homo sapiens	Q96RU7	Anti Tag CoIP	33961781
Intra	APOBEC3C	Q9NRW3	TRIB3	Homo sapiens	Q96RU7	Y2H Prey Pooling	32296183
Intra	APOBEC3C	Q9NRW3	RBMX	Homo sapiens	P38159	Validated Y2H	25416956
Intra	APOBEC3C	Q9NRW3	RBMX	Homo sapiens	P38159	Y2H Array	25416956
Intra	APOBEC3C	Q9NRW3	RBMX	Homo sapiens	P38159	Y2H Prey Pooling	32296183
Intra	APOBEC3C	Q9NRW3	RBMX	Homo sapiens	P38159	Y2H Array	32296183
Intra	APOBEC3C	Q9NRW3	ZNF581	Homo sapiens	Q9P0T4	Validated Y2H	32296183
Intra	APOBEC3C	Q9NRW3	RBMY1A1	Homo sapiens	P0DJD3	Validated Y2H	25416956
Intra	APOBEC3C	Q9NRW3	RBMY1A1	Homo sapiens	P0DJD3	Y2H Prey Pooling	25416956
Intra	APOBEC3C	Q9NRW3	RBMY1F	Homo sapiens	Q15415	Validated Y2H	25416956
Intra	APOBEC3C	Q9NRW3	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	32296183
Intra	APOBEC3C	Q9NRW3	RBMY1F	Homo sapiens	Q15415	Y2H Array	32296183
Intra	APOBEC3C	Q9NRW3	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Plantar Wart

Verruca Plantaris	Verrucae On Sole Of Foot
Mosaic Plantar Warts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00837	APOBEC3C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-120157	Vif-ElonginC interaction inhibitor 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	APOBEC3C	MGD	MGI:1933111

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