APOBEC3C - apolipoprotein B mRNA editing enzyme catalytic subunit 3C Gene

Homo sapiens

Also known as A3C; PBI; ARP5; ARDC2; ARDC4; APOBEC1L; bK150C2.3

Gene ID: 27350 | Gene type: protein coding

About APOBEC3C

Cytogenetic location: 22q13.1 Genomic coordinates (GRCh38): 22:39,014,257-39,020,352 (from NCBI)

This gene has 2 transcripts (splice variants), 55 orthologues and 9 paralogues. Ubiquitous expression in lymph node (RPKM 33.1), testis (RPKM 26.8) and 24 other tissues.

Summary

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. It is thought that the proteins may be RNA editing Enzymes and have roles in growth or cell cycle control. [provided by RefSeq, Jul 2008]

APOBEC3C Products(1)

mRNA	Protein	Name
NM_014508.3	NP_055323.2	DNA dC->dU-editing enzyme APOBEC-3C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	22915799	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in clearance of foreign intracellular DNA	IDA IDA: Inferred from direct assay	20062055	GOA
involved in cytidine deamination	IDA IDA: Inferred from direct assay	21632763	GOA
involved in negative regulation of viral genome replication	IDA IDA: Inferred from direct assay	21632763	GOA
involved in positive regulation of gene expression via chromosomal CpG island demethylation	IDA IDA: Inferred from direct assay	21496894	GOA
involved in retrotransposon silencing	IDA IDA: Inferred from direct assay	16527742	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21835787	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21835787	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOBEC3C Protein Structure

APOBEC_N

0
100
190 a.a.

Protein Preferred Names

Protein Names

DNA dC->dU-editing enzyme APOBEC-3C

apolipoprotein B editing enzyme catalytic polypeptide-like 3C

Related Diseases

Diseases

Alias

Plantar Wart

Verruca Plantaris	Verrucae On Sole Of Foot
Mosaic Plantar Warts

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00837	APOBEC3C Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-120157	Vif-ElonginC interaction inhibitor 1	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	APOBEC3C	MGD	MGI:1933111

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