RBMX - RNA binding motif protein X-linked Gene

Homo sapiens

Also known as RNMX; HNRPG; HNRNPG; MRXS11; RBMXP1; RBMXRT; hnRNP-G

Gene ID: 27316 | Gene type: protein coding

About RBMX

Cytogenetic location: Xq26.3 Genomic coordinates (GRCh38): X:136,869,192-136,880,725 (from NCBI)

This gene has 12 transcripts (splice variants), 70 orthologues, 36 paralogues and is associated with 1 phenotype. Ubiquitous expression in ovary (RPKM 77.9), lymph node (RPKM 53.8) and 25 other tissues.

Summary

This gene belongs to the RBMY gene family which includes candidate Y chromosome spermatogenesis genes. This gene, an active X chromosome homolog of the Y chromosome RBMY gene, is widely expressed whereas the RBMY gene evolved a male-specific function in spermatogenesis. Pseudogenes of this gene, found on chromosomes 1, 4, 9, 11, and 6, were likely derived by retrotransposition from the original gene. Alternatively spliced transcript variants encoding different isoforms have been identified. A snoRNA gene (SNORD61) is found in one of its introns. [provided by RefSeq, Sep 2009]

RBMX Products(2)

mRNA	Protein	Name
NM_001164803.2	NP_001158275.1	RNA-binding motif protein, X chromosome isoform 2
NM_002139.4	NP_002130.2	RNA-binding motif protein, X chromosome isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IDA IDA: Inferred from direct assay	21327109	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	18541147	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	18541147	GOA
enables identical protein binding	IDA IDA: Inferred from direct assay	10749975	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables mRNA binding	IDA IDA: Inferred from direct assay	12165565	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10332027	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	10749975	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	18445477	GOA
involved in membrane protein ectodomain proteolysis	IDA IDA: Inferred from direct assay	18445477	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18541147	GOA
involved in regulation of alternative mRNA splicing, via spliceosome	IDA IDA: Inferred from direct assay	12165565	GOA
involved in transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	21327109	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of catalytic step 2 spliceosome	IDA IDA: Inferred from direct assay	11991638	GOA
located in euchromatin	IDA IDA: Inferred from direct assay	21327109	GOA
located in extracellular exosome	IDA IDA: Inferred from direct assay	18445477	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10749975	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	10749975	GOA
part of supraspliceosomal complex	IDA IDA: Inferred from direct assay	19282290	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RBMX Protein Structure

RRM_1

RBM1CTR

0
100
200
300
391 a.a.

Protein Preferred Names

Protein Names

RNA-binding motif protein, X chromosome

glycoprotein p43

RBMX Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RBMX	P38159	ROBO3	Homo sapiens	Q96HH0	Y2H Prey Pooling	25416956
Intra	RBMX	P38159	ROBO3	Homo sapiens	Q96HH0	Validated Y2H	25416956
Intra	RBMX	P38159	PCDHB14	Homo sapiens	Q9Y5E9	Validated Y2H	32296183
Intra	RBMX	P38159	APOBEC3C	Homo sapiens	Q9NRW3	Validated Y2H	32296183
Intra	RBMX	P38159	APOBEC3C	Homo sapiens	Q9NRW3	Y2H Prey Pooling	25416956
Intra	RBMX	P38159	CMTM6	Homo sapiens	Q9NX76	Y2H Prey Pooling	32296183
Intra	RBMX	P38159	CMTM6	Homo sapiens	Q9NX76	Validated Y2H	32296183
Intra	RBMX	P38159	CMTM6	Homo sapiens	Q9NX76	Y2H Array	32296183
Intra	RBMX	P38159	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Prey Pooling	32296183
Intra	RBMX	P38159	RBMY1A1	Homo sapiens	P0DJD3-2	Y2H Array	32296183
Intra	RBMX	P38159	NYX	Homo sapiens	Q9GZU5	Validated Y2H	32296183
Intra	RBMX	P38159	KHDRBS1	Homo sapiens	Q07666	Anti Tag CoIP	35271311
Intra	RBMX	P38159	PRPF31	Homo sapiens	Q8WWY3	Validated Y2H	32296183
Intra	RBMX	P38159	PRR3	Homo sapiens	P79522	Validated Y2H	32296183
Intra	RBMX	P38159	PRR3	Homo sapiens	P79522	Y2H Array	25416956
Intra	RBMX	P38159	MYPOP	Homo sapiens	Q86VE0	Validated Y2H	32296183
Intra	RBMX	P38159	NABP1	Homo sapiens	Q96AH0	Validated Y2H	32296183
Intra	RBMX	P38159	RBM3	Homo sapiens	P98179	Validated Y2H	32296183
Intra	RBMX	P38159	RBM3	Homo sapiens	P98179	Y2H Array	29892012
Intra	RBMX	P38159	RBM3	Homo sapiens	P98179	Y2H Prey Pooling	25416956
Intra	RBMX	P38159	SRSF9	Homo sapiens	Q13242	Y2H Prey Pooling	32296183
Intra	RBMX	P38159	SRSF9	Homo sapiens	Q13242	Validated Y2H	32296183
Intra	RBMX	P38159	SRSF9	Homo sapiens	Q13242	Y2H Array	32296183
Intra	RBMX	P38159	SRSF9	Homo sapiens	Q13242	Anti Tag CoIP	35271311
Intra	RBMX	P38159	HNRNPK	Homo sapiens	P61978	Y2H Prey Pooling	25416956
Intra	RBMX	P38159	HNRNPK	Homo sapiens	P61978	Y2H Array	25416956
Intra	RBMX	P38159	HNRNPK	Homo sapiens	P61978	Y2H	21516116
Intra	RBMX	P38159	HNRNPK	Homo sapiens	P61978	Validated Y2H	25416956
Intra	RBMX	P38159	SRSF3	Homo sapiens	P84103	Validated Y2H	32296183
Intra	RBMX	P38159	SRSF3	Homo sapiens	P84103	Y2H Prey Pooling	32296183
Intra	RBMX	P38159	SRSF3	Homo sapiens	P84103	Y2H Array	32296183
Intra	RBMX	P38159	TARDBP	Homo sapiens	Q13148	Y2H Array	32814053
Intra	RBMX	P38159	TARDBP	Homo sapiens	Q13148	Validated Y2H	32814053
Intra	RBMX	P38159	TARDBP	Homo sapiens	Q13148	Y2H Pooling	32814053
Intra	RBMX	P38159	FUS	Homo sapiens	P35637	Y2H	21988832
Intra	RBMX	P38159	FUS	Homo sapiens	P35637	Anti Tag CoIP	35271311
Intra	RBMX	P38159	CIRBP	Homo sapiens	Q14011	Validated Y2H	25416956
Intra	RBMX	P38159	SNRPA	Homo sapiens	P09012	Validated Y2H	25416956
Intra	RBMX	P38159	SNRPA	Homo sapiens	P09012	Y2H Array	25416956
Intra	RBMX	P38159	HNRNPK	Homo sapiens	P61978-2	Validated Y2H	32296183
Intra	RBMX	P38159	HNRNPK	Homo sapiens	P61978-2	Y2H Array	32296183
Intra	RBMX	P38159	HNRNPK	Homo sapiens	P61978-2	Y2H Prey Pooling	32296183
Intra	RBMX	P38159	HNRNPK	Homo sapiens	P61978-2	Complementation	32296183
Intra	RBMX	P38159	KHDRBS3	Homo sapiens	O75525	Y2H Prey Pooling	32296183
Intra	RBMX	P38159	KHDRBS3	Homo sapiens	O75525	Y2H Array	32296183
Intra	RBMX	P38159	TRA2B	Homo sapiens	P62995	Y2H	22365833
Intra	RBMX	P38159	TRA2B	Homo sapiens	P62995	Validated Y2H	32296183
Intra	RBMX	P38159	TRA2B	Homo sapiens	P62995	Y2H Array	32296183
Intra	RBMX	P38159	TRA2B	Homo sapiens	P62995	Y2H Prey Pooling	32296183
Intra	RBMX	P38159	LNX1	Homo sapiens	Q8TBB1	Y2H Pooling	16189514
Intra	RBMX	P38159	LNX1	Homo sapiens	Q8TBB1	Validated Y2H	32296183
Intra	RBMX	P38159	CNNM3	Homo sapiens	Q8NE01	Validated Y2H	32296183
Intra	RBMX	P38159	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	32296183
Intra	RBMX	P38159	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Array	25416956
Intra	RBMX	P38159	KHDRBS2	Homo sapiens	Q5VWX1	BFG-2H	27107012
Intra	RBMX	P38159	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Pooling	16189514
Intra	RBMX	P38159	KHDRBS2	Homo sapiens	Q5VWX1	Y2H Prey Pooling	25416956
Intra	RBMX	P38159	KHDRBS2	Homo sapiens	Q5VWX1	Validated Y2H	25416956
Intra	RBMX	P38159	RBMX	Homo sapiens	P38159	Validated Y2H	32296183
Intra	RBMX	P38159	RBMX	Homo sapiens	P38159	Y2H Array	25416956
Intra	RBMX	P38159	RBMX	Homo sapiens	P38159	BFG-2H	27107012
Intra	RBMX	P38159	RBMX	Homo sapiens	P38159	Y2H Array	32296183
Intra	RBMX	P38159	RBMX	Homo sapiens	P38159	Anti Tag CoIP	35271311
Intra	RBMX	P38159	RBMX	Homo sapiens	P38159	Validated Y2H	27107012
Intra	RBMX	P38159	RBMX	Homo sapiens	P38159	Y2H Prey Pooling	32296183
Intra	RBMX	P38159	CLK3	Homo sapiens	P49761	Y2H Array	25416956
Intra	RBMX	P38159	MAGOHB	Homo sapiens	Q96A72	Validated Y2H	25416956
Intra	RBMX	P38159	RBMY1A1	Homo sapiens	P0DJD3	Y2H Prey Pooling	25416956
Intra	RBMX	P38159	RBMY1F	Homo sapiens	Q15415	Validated Y2H	32296183
Intra	RBMX	P38159	RBMY1F	Homo sapiens	Q15415	Y2H Array	25416956
Intra	RBMX	P38159	RBMY1F	Homo sapiens	Q15415	Y2H Array	32296183
Intra	RBMX	P38159	RBMY1F	Homo sapiens	Q15415	Y2H Prey Pooling	32296183
Cross	RBMX	P38159	Srek1	Rattus norvegicus	Q9JKL7	Pull Down	14559993

Cross: Cross-species interaction Intra: Intraspecies interaction

RBMX Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83284	hnRNP G Antibody (YA3029)	WB, IHC-F, IHC-P, ICC/IF	Human

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, X-Linked, Syndromic 11

MRXS11	Shashi X-Linked Mental Retardation Syndrome
Smrxs	X-Linked Intellectual Disability, Shashi Type
Mental Retardation, X-Linked, Shashi Type	Intellectual Developmental Disorder, X-Linked Syndromic 11, Shashi Type
Mental Retardation X-Linked Shashi Type	Syndromic X-Linked Intellectual Disability Type 11
Intellectual Developmental Disorder, Syndromic 11, Shashi Type

Syndromic X-Linked Intellectual Disability Shashi Type

Mental Retardation, X-Linked, Syndromic 11, Shashi Type	Mrxs11
Shashi X-Linked Mental Retardation Syndrome	Smrxs
Syndromic X-Linked Intellectual Disability Type 11	X-Linked Mental Retardation Shashi Type
Mental Retardation, X-Linked, Syndromic 11

Thrombophilia, X-Linked, Due To Factor Ix Defect

THPH8	Deep Venous Thrombosis, Protection Against
X-Linked Thrombophilia Due To Factor Ix Defect	Thrombophilia, X-Linked, Due To Factor 9 Defect
Thrombophilia 8, X-Linked, Due To Factor Ix Defect

Borna Disease

Enzootic Encephalomyelitis

Lissencephaly, X-Linked, 2

X-Linked Lissencephaly With Abnormal Genitalia	Hydranencephaly With Abnormal Genitalia
Xlag	Xlisg
X-Linked Lissencephaly With Ambiguous Genitalia	LISX2
Lissencephaly, X-Linked 2	X-Linked Lissencephaly 2
X-Linked Lissencephaly-Corpus Callosum Agenesis-Genital Anomalies Syndrome	Xlag Syndrome
Lissencephaly, X-Linked, With Ambiguous Genitalia	Xlis2
X-Linked Lissencephaly - Agenesis Of The Corpus Callosum - Genital Anomalies	X-Linked Lissencephaly-Agenesis Of The Corpus Callosum-Genital Anomalies Syndrome
Xlag Syndrome	Lissencephaly X-Linked With Ambiguous Genitalia
Lissencephaly, X-Linked, Type 2	Chromosome Xq26.3 Duplication Syndrome

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

X-Linked Hereditary Ataxia

Fragile X-Associated Tremor/Ataxia Syndrome

Fxtas Syndrome	Fragile X Tremor/Ataxia Syndrome
Fxtas

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11763	RBMX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RBMX	MGD	MGI:1343044
Bos taurus	RBMX	VGNC	VGNC:56951
Canis familiaris	RBMX	VGNC	VGNC:54838
Rattus norvegicus	RBMX	RGD	RGD:1565256

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