MAT2B - methionine adenosyltransferase 2B Gene

Homo sapiens

Also known as TGR; MAT-II; SDR23E1; MATIIbeta; Nbla02999

Gene ID: 27430 | Gene type: protein coding

About MAT2B

Cytogenetic location: 5q34 Genomic coordinates (GRCh38): 5:163,503,064-163,519,354 (from NCBI)

This gene has 33 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in lymph node (RPKM 45.7), thyroid (RPKM 43.7) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the methionine adenosyltransferase (MAT) family. MAT catalyzes the biosynthesis of S-adenosylmethionine from methionine and ATP. This protein is the regulatory beta subunit of MAT. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

MAT2B Products(2)

mRNA	Protein	Name
NM_013283.5	NP_037415.1	methionine adenosyltransferase 2 subunit beta isoform 1
NM_182796.2	NP_877725.1	methionine adenosyltransferase 2 subunit beta isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IPI IPI: Inferred from physical interaction	10644686	GOA
enables methionine adenosyltransferase regulator activity	IDA IDA: Inferred from direct assay	10644686	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25075345	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in S-adenosylmethionine biosynthetic process	IDA IDA: Inferred from direct assay	10644686	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of methionine adenosyltransferase complex	IDA IDA: Inferred from direct assay	10644686	GOA
part of methionine adenosyltransferase complex	IPI IPI: Inferred from physical interaction	25075345	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAT2B Protein Structure

RmlD_sub_bind

0
100
200
300
334 a.a.

Protein Preferred Names

Protein Names

methionine adenosyltransferase 2 subunit beta

MAT II beta

MAT2B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MAT2B	Q9NZL9	MAT2A	Homo sapiens	P31153	Anti Tag CoIP	33961781
Intra	MAT2B	Q9NZL9	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	MAT2B	Q9NZL9	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	MAT2B	Q9NZL9	PLA2G6	Homo sapiens	O60733	Y2H Prey Pooling	32296183
Intra	MAT2B	Q9NZL9	PLA2G6	Homo sapiens	O60733	Y2H Array	32296183
Cross	MAT2B	Q9NZL9	P0DTD1-PRO_0000449627	SARS-CoV-2	P0DTD1-PRO_0000449627	Y2H Array	36217030
Intra	MAT2B	Q9NZL9	KPNA3	Homo sapiens	O00505	Y2H Array	32296183
Intra	MAT2B	Q9NZL9	KPNA3	Homo sapiens	O00505	Y2H Prey Pooling	25416956
Intra	MAT2B	Q9NZL9	KPNA3	Homo sapiens	O00505	Y2H Prey Pooling	32296183
Intra	MAT2B	Q9NZL9	RABEP1	Homo sapiens	Q15276	Y2H Array	32296183
Intra	MAT2B	Q9NZL9	RABEP1	Homo sapiens	Q15276	Y2H Prey Pooling	32296183
Intra	MAT2B	Q9NZL9	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	MAT2B	Q9NZL9	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency	Deficiency Of Methionine Adenosyltransferase
Glycine N-Methyltransferase Deficiency	Met
S-Adenosylhomocysteine Hydrolase Deficiency	Gnmt Deficiency
Mat Deficiency	Methionine Adenosyltransferase Deficiency
Methioninemia	Deficiency Of Acetyl-Coa Acetyltransferase

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08168	MAT2B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	MAT2B	MGD	MGI:1913667
Canis familiaris	MAT2B	VGNC	VGNC:43038
Rattus norvegicus	MAT2B	RGD	RGD:1593534
Felis catus	MAT2B	VGNC	VGNC:102251
Macaca mulatta	MAT2B	VGNC	VGNC:84437
Bos taurus	MAT2B	VGNC	VGNC:31262

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