MAT2A - methionine adenosyltransferase 2A Gene

Homo sapiens

Also known as MATA2; MATII; SAMS2

Gene ID: 4144 | Gene type: protein coding

About MAT2A

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:85,539,168-85,545,281 (from NCBI)

This gene has 6 transcripts (splice variants), 292 orthologues, 1 paralogue and is associated with 1 phenotype. Ubiquitous expression in thyroid (RPKM 234.0), adrenal (RPKM 141.3) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the production of S-adenosylmethionine (AdoMet) from methionine and ATP. AdoMet is the key methyl donor in cellular processes. [provided by RefSeq, Jun 2011]

MAT2A Products(1)

mRNA	Protein	Name
NM_005911.6	NP_005902.1	S-adenosylmethionine synthase isoform type-2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables methionine adenosyltransferase activity	IDA IDA: Inferred from direct assay	7665609	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10644686	GOA
enables small molecule binding	EXP EXP: Inferred from Experiment	26858410	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in S-adenosylmethionine biosynthetic process	IDA IDA: Inferred from direct assay	10644686	GOA
involved in cellular response to methionine	IDA IDA: Inferred from direct assay	38006878	GOA
involved in positive regulation of TORC1 signaling	IDA IDA: Inferred from direct assay	38006878	GOA
involved in protein heterooligomerization	IDA IDA: Inferred from direct assay	25075345	GOA
involved in protein hexamerization	IDA IDA: Inferred from direct assay	25075345	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of methionine adenosyltransferase complex	IDA IDA: Inferred from direct assay	10644686	GOA
part of methionine adenosyltransferase complex	IPI IPI: Inferred from physical interaction	25075345	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAT2A Protein Structure

S-AdoMet_synt_N

S-AdoMet_synt_M

S-AdoMet_synt_C

0
100
200
300
395 a.a.

Protein Preferred Names

Protein Names

S-adenosylmethionine synthase isoform type-2

MAT 2

Related Diseases

Diseases

Alias

Glycine N-Methyltransferase Deficiency

GNMT DEFICIENCY	Hypermethioninemia Due To Glycine N-Methyltransferase Deficiency
Hypermethioninemia Due To Gnmt Deficiency	Hypermethioninemia
Hepatic Methionine Adenosyltransferase Deficiency

Aortic Aneurysm, Familial Thoracic 1

Thoracic Aortic Aneurysm	Annuloaortic Ectasia
Familial Thoracic Aortic Aneurysm And Aortic Dissection	Familial Aortic Dissection
Familial Taad	Familial Thoracic Aortic Aneurysm
Congenital Aneurysm Of Ascending Aorta	Familial Aortic Aneurysm
Familial Thoracic Aortic Aneurysm And Dissection	Aortic Aneurysm, Thoracic
AAT1	Faa1
Aortic Dissection, Familial	Aortic Aneurysm, Familial Thoracic
Aneurysm, Thoracic Aortic	Faa
Ftaad	Taa
Taad	Cystic Medial Necrosis Of Aorta
Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection	Aortic Aneurysm Thoracic
Familial Aortic Aneurysms	Aneurysm, Aortic, Thoracic, Familial, Type 1
Aneurysm Of Thoracic Aorta	Intrathoracic Aneurysm
Thoracic Aorta Aneurysm	Thoracic Aortic Aneurysm Without Rupture
Thoracic Aneurysm	Thorax Arterial Aneurysm
Thoracic Artery Aneurysm	Thoracic Arterial Aneurysm
Thorax Aneurysm	Thorax Aortic Aneurysm
Dissection Of Thoracic Aorta

Hypermethioninemia

Hepatic Methionine Adenosyltransferase Deficiency	Deficiency Of Methionine Adenosyltransferase
Glycine N-Methyltransferase Deficiency	Met
S-Adenosylhomocysteine Hydrolase Deficiency	Gnmt Deficiency
Mat Deficiency	Methionine Adenosyltransferase Deficiency
Methioninemia	Deficiency Of Acetyl-Coa Acetyltransferase

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Loeys-Dietz Syndrome

Loeys-Dietz Aortic Aneurysm Syndrome	Lds
Aortic Aneurysm Syndrome Due To Tgf-Beta Receptors Anomalies	Furlong Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-138630	AG-270		99.85%	Phase 1

Pre-clinical Phase

Bioactive Molecules (28)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107778	PF-9366		99.98%	Unkown
HY-136144	FIDAS-5		98.88%	Unkown
HY-112130	AGI-24512	Inhibitor	99.59%	Unkown
HY-145778	AGI-41998		99.94%	Unkown
HY-139139	MAT2A inhibitor 3		99.27%	Unkown
HY-145777	AGI-43192		99.53%	Unkown
HY-112569	MAT2A inhibitor 2	Inhibitor	99.71%	Unkown
HY-112131	MAT2A inhibitor 1		99.57%	Unkown
HY-162353	AZ'9567	Inhibitor	99.21%	Unkown
HY-136145	FIDAS-3	Inhibitor	99.40%	Unkown
HY-139536	MAT2A inhibitor 4		99.84%	Unkown
HY-142928	MAT2A-IN-1	Inhibitor	/	Unkown
HY-142929	MAT2A-IN-2	Inhibitor	/	Unkown
HY-142930	MAT2A-IN-3	Inhibitor	/	Unkown
HY-144179	MAT2A-IN-4	Inhibitor	/	Unkown
HY-144181	MAT2A-IN-5	Inhibitor	/	Unkown
HY-144184	MAT2A-IN-6	Inhibitor	/	Unkown
HY-144185	MAT2A-IN-7	Inhibitor	/	Unkown
HY-149915	MAT2A-IN-10	Inhibitor	/	Unkown
HY-155148	MAT2A-IN-11	Inhibitor	/	Unkown
HY-155149	MAT2A-IN-12	Inhibitor	/	Unkown
HY-159156	MAT2A inhibitor 6		/	Unkown
HY-161298	MAT2A-IN-15	Inhibitor	/	Unkown
HY-162010	MAT2A-IN-13	Inhibitor	/	Unkown
HY-162135	MAT2A-IN-14		/	Unkown
HY-163656	MAT2A inhibitor 5	Inhibitor	/	Unkown
HY-169257	SCR-7952	Inhibitor	/	Unkown
HY-RS08167	MAT2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MAT2A	VGNC	VGNC:50214
Canis familiaris	MAT2A	VGNC	VGNC:49922
Felis catus	MAT2A	VGNC	VGNC:68193
Rattus norvegicus	MAT2A	RGD	RGD:619985
Mus musculus	MAT2A	MGD	MGI:2443731
Macaca mulatta	MAT2A	VGNC	VGNC:74664
Others	MAT2A	NCBI

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