KPNA3 - karyopherin subunit alpha 3 Gene

Homo sapiens

Also known as SRP1; SRP4; IPOA4; SPG88; hSRP1; SRP1gamma

Gene ID: 3839 | Gene type: protein coding

About KPNA3

Cytogenetic location: 13q14.2 Genomic coordinates (GRCh38): 13:49,699,320-49,792,682 (from NCBI)

This gene has 2 transcripts (splice variants), 232 orthologues, 6 paralogues and is associated with 1 phenotype. Ubiquitous expression in testis (RPKM 17.5), brain (RPKM 15.2) and 25 other tissues.

Summary

The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC), which consists of 60-100 proteins. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion while larger molecules are transported by an active process. The protein encoded by this gene belongs to the importin alpha family, and is involved in nuclear protein import. [provided by RefSeq, Jan 2009]

KPNA3 Products(1)

mRNA	Protein	Name
NM_002267.4	NP_002258.2	importin subunit alpha-4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10523667	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of NLS-dependent protein nuclear import complex	IPI IPI: Inferred from physical interaction	10523667	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KPNA3 Protein Structure

IBB

Arm

0
100
200
300
400
521 a.a.

Protein Preferred Names

Protein Names

importin subunit alpha-4

SRP1-gamma

KPNA3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KPNA3	O00505	CCDC102B	Homo sapiens	Q68D86	Validated Y2H	32296183
Intra	KPNA3	O00505	ApoL6	Homo sapiens	B3KTP4	Validated Y2H	25416956
Intra	KPNA3	O00505	SLC5A11	Homo sapiens	Q8WWX8	Y2H Array	25416956
Intra	KPNA3	O00505	SLC5A11	Homo sapiens	Q8WWX8	Y2H Prey Pooling	25416956
Intra	KPNA3	O00505	q9brl8_human	Homo sapiens	Q9BRL8	Y2H Array	25416956
Intra	KPNA3	O00505	q9brl8_human	Homo sapiens	Q9BRL8	Validated Y2H	25416956
Intra	KPNA3	O00505	q9brl8_human	Homo sapiens	Q9BRL8	Y2H Prey Pooling	25416956
Intra	KPNA3	O00505	MAT2B	Homo sapiens	Q9NZL9	Validated Y2H	25416956
Intra	KPNA3	O00505	MAT2B	Homo sapiens	Q9NZL9	Validated Y2H	32296183
Intra	KPNA3	O00505	MAT2B	Homo sapiens	Q9NZL9	Y2H Array	25416956
Intra	KPNA3	O00505	RPRD1A	Homo sapiens	Q96P16	Y2H Array	25416956
Intra	KPNA3	O00505	UVSSA	Homo sapiens	Q2YD98	Validated Y2H	32296183
Intra	KPNA3	O00505	ERCC3	Homo sapiens	P19447	Validated Y2H	32296183
Intra	KPNA3	O00505	ERCC3	Homo sapiens	P19447	Y2H	21988832
Intra	KPNA3	O00505	TMEM276	Homo sapiens	P0DTL5	Validated Y2H	32296183
Intra	KPNA3	O00505	ESR2	Homo sapiens	Q92731-3	Validated Y2H	32296183
Intra	KPNA3	O00505	GRB10	Homo sapiens	Q13322-4	Validated Y2H	32296183
Intra	KPNA3	O00505	L3MBTL4	Homo sapiens	Q8NA19-2	Validated Y2H	32296183
Intra	KPNA3	O00505	BRD3	Homo sapiens	Q15059-2	Validated Y2H	32296183
Intra	KPNA3	O00505	ANKRD11	Homo sapiens	X5D778	Validated Y2H	32296183
Intra	KPNA3	O00505	NUP50	Homo sapiens	Q9UKX7	Validated Y2H	32296183
Intra	KPNA3	O00505	NUP50	Homo sapiens	Q9UKX7	Y2H Array	25416956
Intra	KPNA3	O00505	NUP50	Homo sapiens	Q9UKX7	Validated Y2H	25416956
Intra	KPNA3	O00505	TNIP3	Homo sapiens	Q96KP6	Validated Y2H	32296183
Intra	KPNA3	O00505	KPNB1	Homo sapiens	Q14974	Anti Tag CoIP	35271311
Intra	KPNA3	O00505	HNRNPC	Homo sapiens	P07910	Y2H Array	25416956
Intra	KPNA3	O00505	HNRNPC	Homo sapiens	P07910	Validated Y2H	25416956
Intra	KPNA3	O00505	NMNAT1	Homo sapiens	Q9HAN9	Validated Y2H	32296183
Intra	KPNA3	O00505	KAT5	Homo sapiens	Q92993	Validated Y2H	32296183
Intra	KPNA3	O00505	HTT	Homo sapiens	P42858	Y2H Pooling	32814053
Intra	KPNA3	O00505	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	KPNA3	O00505	HTT	Homo sapiens	P42858	Validated Y2H	32814053
Intra	KPNA3	O00505	HTT	Homo sapiens	P42858	Y2H Array	32814053
Intra	KPNA3	O00505	POLR3C	Homo sapiens	Q9BUI4	Validated Y2H	32296183
Intra	KPNA3	O00505	HEXIM2	Homo sapiens	Q96MH2	Validated Y2H	32296183
Intra	KPNA3	O00505	ZCCHC10	Homo sapiens	Q8TBK6	Validated Y2H	25416956
Intra	KPNA3	O00505	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Prey Pooling	25416956
Intra	KPNA3	O00505	ZCCHC10	Homo sapiens	Q8TBK6	Y2H Array	25416956
Intra	KPNA3	O00505	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	KPNA3	O00505	RAD52	Homo sapiens	P43351	Validated Y2H	32296183
Intra	KPNA3	O00505	FTL	Homo sapiens	P02792	Y2H Array	25416956
Intra	KPNA3	O00505	FTL	Homo sapiens	P02792	Y2H Prey Pooling	25416956
Intra	KPNA3	O00505	MAPK9	Homo sapiens	P45984	Validated Y2H	32296183
Intra	KPNA3	O00505	MTA1	Homo sapiens	Q13330	Y2H Array	25416956
Intra	KPNA3	O00505	TSSC4	Homo sapiens	Q9Y5U2	Y2H Array	25416956
Intra	KPNA3	O00505	TSSC4	Homo sapiens	Q9Y5U2	Y2H Prey Pooling	25416956
Intra	KPNA3	O00505	TSSC4	Homo sapiens	Q9Y5U2	Validated Y2H	25416956
Intra	KPNA3	O00505	ZNF76	Homo sapiens	P36508	Validated Y2H	32296183
Intra	KPNA3	O00505	BAHD1	Homo sapiens	Q8TBE0	Validated Y2H	32296183
Intra	KPNA3	O00505	SPMIP9	Homo sapiens	Q96LM6	Validated Y2H	25416956
Intra	KPNA3	O00505	SPMIP9	Homo sapiens	Q96LM6	Y2H Array	25416956
Intra	KPNA3	O00505	ZBTB24	Homo sapiens	O43167	Validated Y2H	25416956
Intra	KPNA3	O00505	ZBTB24	Homo sapiens	O43167	Y2H Prey Pooling	25416956
Intra	KPNA3	O00505	ZBTB24	Homo sapiens	O43167	Y2H Array	25416956
Intra	KPNA3	O00505	ATOSB	Homo sapiens	Q7L5A3	Validated Y2H	32296183
Intra	KPNA3	O00505	ZNF764	Homo sapiens	Q96H86	Validated Y2H	32296183
Intra	KPNA3	O00505	ZCCHC12	Homo sapiens	Q6PEW1	Validated Y2H	32296183
Cross	KPNA3	O00505	PB2	Influenza A virus	P03427	SLC	23816991

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spastic Paraplegia 37, Autosomal Dominant

SPG37	Autosomal Dominant Spastic Paraplegia Type 37
Hereditary Spastic Paraplegia 37	Autosomal Dominant Spastic Paraplegia 37

Influenza

Flu	Influenza With Non-Respiratory Manifestation
Influenza With Other Manifestations	Influenza, Human
Influenza, Susceptibility To	Seasonal Influenza, Virus Identified

Charcot-Marie-Tooth Disease, Axonal, Type 2dd

CMT2DD	Charcot-Marie-Tooth Neuropathy, Type 2dd
Charcot-Marie-Tooth Disease Type 2dd	Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Atp1a1-Related Cmt2	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd
Charcot-Marie-Tooth Disease 2dd

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07417	KPNA3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KPNA3	VGNC	VGNC:67975
Rattus norvegicus	KPNA3	RGD	RGD:1311339
Canis familiaris	KPNA3	VGNC	VGNC:42501
Macaca mulatta	KPNA3	VGNC	VGNC:74200
Mus musculus	KPNA3	MGD	MGI:1100863
Bos taurus	KPNA3	VGNC	VGNC:30702

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