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  3. GNAI3 - G protein subunit alpha i3 Gene

GNAI3 - G protein subunit alpha i3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as 87U6; HG1A; ARCND1

Gene ID: 2773 | Gene type: protein coding

About GNAI3

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,548,615-109,600,195 (from NCBI)

This gene has 1 transcript (splice variant), 235 orthologues, 15 paralogues and is associated with 3 phenotypes. Ubiquitous expression in esophagus (RPKM 27.0), bone marrow (RPKM 22.0) and 25 other tissues.

Summary

Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling pathways. G proteins are composed of 3 units: alpha, beta and gamma. This gene encodes an alpha subunit and belongs to the G-alpha family. Mutation in this gene, resulting in a gly40-to-arg substitution, is associated with auriculocondylar syndrome, and shown to affect downstream targets in the G protein-coupled Endothelin Receptor pathway. [provided by RefSeq, Jun 2012]

GNAI3 Products(1)

mRNA Protein Name
NM_006496.4 NP_006487.1 guanine nucleotide-binding protein G(i) subunit alpha-3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables GDP binding IDA
IDA: Inferred from direct assay
19478087 GOA
enables GTPase activity IDA
IDA: Inferred from direct assay
19478087 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
18434541 GOA
Biological Process GO Annotation Evidence Reference Source
involved in GTP metabolic process IDA
IDA: Inferred from direct assay
19478087 GOA
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: Inferred from direct assay
19478087 GOA
involved in cell division IDA
IDA: Inferred from direct assay
17635935 GOA
involved in positive regulation of macroautophagy IMP
IMP: Inferred from mutant phenotype
12642577 GOA
Cellular Component GO Annotation Evidence Reference Source
colocalizes with Golgi membrane IDA
IDA: Inferred from direct assay
12642577 GOA
located in centrosome IDA
IDA: Inferred from direct assay
17635935 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17635935 GOA
colocalizes with endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
12642577 GOA
located in midbody IDA
IDA: Inferred from direct assay
17635935 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
17635935 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GNAI3 Protein Structure

G-alpha

G-alpha: G-protein alpha subunit (6 - 343)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(i) subunit alpha-3

g(i) alpha-3

GNAI3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
GNAI3 P08754 PCP2 Homo sapiens Q8IVA1
Y2H Prey Pooling
32296183
Intra
GNAI3 P08754 PCP2 Homo sapiens Q8IVA1
Validated Y2H
32296183
Intra
GNAI3 P08754 PCP2 Homo sapiens Q8IVA1
Y2H Array
32296183
Intra
GNAI3 P08754 PHF24 Homo sapiens Q9UPV7
Y2H Array
32296183
Intra
GNAI3 P08754 PHF24 Homo sapiens Q9UPV7
Validated Y2H
32296183
Intra
GNAI3 P08754 PHF24 Homo sapiens Q9UPV7
Y2H Prey Pooling
32296183
Intra
GNAI3 P08754 GPSM3 Homo sapiens Q9Y4H4
Validated Y2H
25416956
Intra
GNAI3 P08754 GPSM3 Homo sapiens Q9Y4H4
Validated Y2H
32296183
Intra
GNAI3 P08754 GPSM3 Homo sapiens Q9Y4H4
Y2H Array
25416956
Intra
GNAI3 P08754 RGS17 Homo sapiens Q9UGC6
Validated Y2H
25416956
Intra
GNAI3 P08754 GPSM2 Homo sapiens P81274
Validated Y2H
32296183
Intra
GNAI3 P08754 GPSM2 Homo sapiens P81274
Y2H Array
32296183
Intra
GNAI3 P08754 GPSM2 Homo sapiens P81274
Y2H Prey Pooling
32296183
Intra
GNAI3 P08754 RGS14 Homo sapiens O43566
Y2H Array
32296183
Intra
GNAI3 P08754 RGS14 Homo sapiens O43566
Anti Tag CoIP
33961781
Intra
GNAI3 P08754 RGS14 Homo sapiens O43566
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Auriculocondylar Syndrome 1

Question Mark Ears Syndrome

ARCND1

Dysgnathia Complex

Acs

Auriculocondylar Syndrome, Type 1

Auriculo-Condylar Syndrome

Stomatognathic System Abnormalities
Auriculo-Condylar Syndrome

Auriculocondylar Syndrome

Dysgnathia Complex

Ears Prominent And Constricted

Question Mark Ear

Question-Mark Ear Syndrome

Question Mark Ear Syndrome
Ankylosis
Short-Rib Thoracic Dysplasia 5 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 5

SRTD5

Atd5

Jatd

Jeune Asphyxiating Thoracic Dystrophy

Jeune Syndrome 5
Frontonasal Dysplasia 1

Frontorhiny

Frontonasal Dysplasia

Fnd

Frontonasal Malformation

Fnm

Median Facial Cleft Syndrome

Midline Facial Cleft

FND1

Median Cleft Face Syndrome

Median Cleft Syndrome

Frontonasal Dysplasia Sequence

Median Facial Cleft

Tessier Number 0-14 And 30 Facial Cleft

Alx3-Related Frontonasal Dysplasia

Frontonasal Dysplasia Type 1

Isolated Median Cleft Face Syndrome

Doid:0081044

Doid:0081045

Dysplasia, Frontonasal, Type
Mandibulofacial Dysostosis With Alopecia

MFDA
Neurodevelopmental Disorder With Involuntary Movements

NEDIM
Agnathia-Otocephaly Complex

Otocephaly

Holoprosencephaly-Agnathia

Dysgnathia Complex Agnathia-Holoprosencephaly

AGOTC

Agnathia-Holoprosencephaly-Situs Inversus Syndrome

Dysgnathia Complex

Agnathia-Holoprosencephaly

Cervical Auricle
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05536 GNAI3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus GNAI3 VGNC VGNC:80220
Rattus norvegicus GNAI3 RGD RGD:2714
Macaca mulatta GNAI3 VGNC VGNC:73091
Canis familiaris GNAI3 VGNC VGNC:41303
Bos taurus GNAI3 VGNC VGNC:29451
Mus musculus GNAI3 MGD MGI:95773