RGS14 - regulator of G protein signaling 14 Gene

Homo sapiens

Gene ID: 10636 | Gene type: protein coding

About RGS14

Cytogenetic location: 5q35.3 Genomic coordinates (GRCh38): 5:177,357,924-177,372,596 (from NCBI)

This gene has 13 transcripts (splice variants), 120 orthologues and 23 paralogues. Broad expression in spleen (RPKM 15.0), lymph node (RPKM 11.5) and 23 other tissues.

Summary

This gene encodes a member of the regulator of G-protein signaling family. This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco domain. The protein attenuates the signaling activity of G-proteins by binding, through its GoLoco domain, to specific types of activated, GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

RGS14 Products(3)

mRNA	Protein	Name
NM_001366617.1	NP_001353546.1	regulator of G-protein signaling 14 isoform 2
NM_001366618.1	NP_001353547.1	regulator of G-protein signaling 14 isoform 3
NM_006480.5	NP_006471.2	regulator of G-protein signaling 14 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP-dissociation inhibitor activity	IDA IDA: Inferred from direct assay	15917656	GOA
enables GTPase activator activity	IDA IDA: Inferred from direct assay	15917656	GOA
enables microtubule binding	IDA IDA: Inferred from direct assay	15917656	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21044950	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell division	IMP IMP: Inferred from mutant phenotype	17635935	GOA
involved in spindle organization	IMP IMP: Inferred from mutant phenotype	15917656	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in spindle	IDA IDA: Inferred from direct assay	15917656	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGS14 Protein Structure

RGS

RBD

GoLoco

0
100
200
300
400
500
566 a.a.

Protein Preferred Names

Protein Names

regulator of G-protein signaling 14

RGS14 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RGS14	O43566	GNAI3	Homo sapiens	P08754	Y2H	21988832
Intra	RGS14	O43566	GNAI3	Homo sapiens	P08754	Validated Y2H	32296183
Intra	RGS14	O43566	GNAI1	Homo sapiens	P63096	Y2H Array	21988832
Intra	RGS14	O43566	GNAI1	Homo sapiens	P63096	Y2H	21988832
Intra	RGS14	O43566	TINF2	Homo sapiens	Q9BSI4	BiFC	21044950
Intra	RGS14	O43566	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nephrolithiasis

Kidney Stones	Stone - Kidney/Ureter
Kidney Calculi

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11907	RGS14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RGS14	VGNC	VGNC:45524
Bos taurus	RGS14	VGNC	VGNC:33914
Mus musculus	RGS14	MGD	MGI:1859709
Rattus norvegicus	RGS14	RGD	RGD:620003
Macaca mulatta	RGS14	VGNC	VGNC:76918
Felis catus	RGS14	VGNC	VGNC:69313
Others	RGS14	NCBI

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