MILR1 - mast cell immunoglobulin like receptor 1 Gene

Homo sapiens

Also known as MCA32; MCA-32; C17orf60; Allergin-1

Gene ID: 284021 | Gene type: protein coding

About MILR1

This gene has 7 transcripts (splice variants), 84 orthologues and 17 paralogues. Broad expression in appendix (RPKM 7.6), lymph node (RPKM 6.4) and 21 other tissues.

Summary

Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in several processes, including cell-cell adhesion via plasma-membrane adhesion molecules; mast cell degranulation; and negative regulation of mast cell activation. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

MILR1 Products(4)

mRNA	Protein	Name
NM_001085423.2	NP_001078892.1	allergin-1 isoform Allergin-1L precursor
NM_001291316.2	NP_001278245.1	allergin-1 isoform Allergin-1S1 precursor
NM_001291317.2	NP_001278246.1	allergin-1 isoform Allergin-1S2 precursor
NM_001369493.1	NP_001356422.1	allergin-1 isoform Allergin-1L precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

allergin-1

allergy inhibitory receptor 1

MILR1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MILR1	Q7Z6M3	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	MILR1	Q7Z6M3	TMEM140	Homo sapiens	Q9NV12	Validated Y2H	32296183
Intra	MILR1	Q7Z6M3	HHATL	Homo sapiens	Q9HCP6	Validated Y2H	32296183
Intra	MILR1	Q7Z6M3	GIMAP5	Homo sapiens	Q96F15	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MILR1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75574	Allergin-1 Protein, Human (HEK293, Fc)	Q7Z6M3-1 (R20-K227)	≥95%
HY-P75575	Allergin-1 Protein, Human (HEK293, His)	Q7Z6M3-1 (R20-K227)	≥95%

Related Diseases

Diseases

Alias

Mitochondrial Dna Depletion Syndrome 16b

MTDPS16B

Mitochondrial Dna Depletion Syndrome 16b, Neuroophthalmic Type

Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 4

PEOA4	Autosomal Dominant Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions 4
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 4	Chronic Progressive External Ophthalmoplegia
Progressive External Ophthalmoplegia, Autosomal Dominant 4	Autosomal Dominant Progressive External Ophthalmoplegia 4
Cpeo	Graefe Disease
Mitochondrial Ocular Myopathy	Ocular Myopathy Of Von Graefe-Fuchs
Progressive External Ophthalmoplegia Autosomal Dominant 4	Ophthalmoplegia, External, Progressive, With Mitochondrial Dna Deletions, Autosomal Dominant, Type 4
Kearns-Sayre Syndrome

Acute Liver Failure

Fulminant Hepatic Failure	Acute Hepatic Failure
Liver Failure Acute	Hepatic Failure Fulminant
Liver Failure, Acute

Theileriasis

Theileriosis

Infection By Theileria

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08449	MILR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MILR1	RGD	RGD:620488
Macaca mulatta	MILR1	VGNC	VGNC:74843
Canis familiaris	MILR1	VGNC	VGNC:43235
Mus musculus	MILR1	MGD	MGI:2685731
Felis catus	MILR1	VGNC	VGNC:63507
Bos taurus	MILR1	VGNC	VGNC:31476
Others	MILR1	NCBI

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