2. Gene
  3. GIMAP5 - GTPase, IMAP family member 5 Gene

GIMAP5 - GTPase, IMAP family member 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as IAN4; IAN5; IROD; IAN-5; IMAP3; NCPH2; HIMAP3; IAN4L1

Gene ID: 55340 | Gene type: protein coding

About GIMAP5

Cytogenetic location: 7q36.1 Genomic coordinates (GRCh38): 7:150,737,418-150,743,646 (from NCBI)

This gene has 7 transcripts (splice variants), 282 orthologues, 7 paralogues and is associated with 1 phenotype. Broad expression in lymph node (RPKM 61.1), spleen (RPKM 41.6) and 21 other tissues.

Summary

This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene encodes an antiapoptotic protein that functions in T-cell survival. Polymorphisms in this gene are associated with systemic lupus erythematosus. Read-through transcription exists between this gene and the neighboring upstream GIMAP1 (GTPase, IMAP family member 1) gene. [provided by RefSeq, Dec 2010]

GIMAP5 Products(1)

mRNA Protein Name
NM_018384.5 NP_060854.2 GTPase IMAP family member 5

GIMAP5 Protein Structure

AIG1

AIG1: AIG1 family (28 - 230)

  • 0
  • 100
  • 200
  • 307 a.a.
Protein Preferred Names Protein Names

GTPase IMAP family member 5

immune associated nucleotide 4 like 1

GIMAP5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra GIMAP5 Q96F15 LDLRAD1 Homo sapiens Q5T700
Validated Y2H
25416956
Intra GIMAP5 Q96F15 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 LDLRAD1 Homo sapiens Q5T700
Y2H Array
25416956
Intra GIMAP5 Q96F15 LDLRAD1 Homo sapiens Q5T700
Y2H Array
32296183
Intra GIMAP5 Q96F15 LDLRAD1 Homo sapiens Q5T700
Y2H Prey Pooling
25416956
Intra GIMAP5 Q96F15 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra GIMAP5 Q96F15 LSMEM2 Homo sapiens Q8N112
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 LSMEM2 Homo sapiens Q8N112
Y2H Array
25416956
Intra GIMAP5 Q96F15 LSMEM2 Homo sapiens Q8N112
Y2H Array
32296183
Intra GIMAP5 Q96F15 LSMEM2 Homo sapiens Q8N112
Y2H Prey Pooling
25416956
Intra GIMAP5 Q96F15 JAGN1 Homo sapiens Q8N5M9
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 JAGN1 Homo sapiens Q8N5M9
Y2H Array
32296183
Intra GIMAP5 Q96F15 TMX1 Homo sapiens Q9H3N1
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 TMX1 Homo sapiens Q9H3N1
Validated Y2H
32296183
Intra GIMAP5 Q96F15 TMX1 Homo sapiens Q9H3N1
Y2H Array
32296183
Intra GIMAP5 Q96F15 PTGES Homo sapiens O14684
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 PTGES Homo sapiens O14684
Y2H Array
32296183
Intra GIMAP5 Q96F15 MGST2 Homo sapiens Q99735
Y2H Array
32296183
Intra GIMAP5 Q96F15 MGST2 Homo sapiens Q99735
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 MGST2 Homo sapiens Q99735
Validated Y2H
32296183
Intra GIMAP5 Q96F15 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra GIMAP5 Q96F15 STX2 Homo sapiens P32856-2
Y2H Array
32296183
Intra GIMAP5 Q96F15 STX2 Homo sapiens P32856-2
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 TNFRSF19 Homo sapiens Q9NS68-2
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 TNFRSF19 Homo sapiens Q9NS68-2
Validated Y2H
32296183
Intra GIMAP5 Q96F15 TNFRSF19 Homo sapiens Q9NS68-2
Y2H Array
32296183
Intra GIMAP5 Q96F15 STOM Homo sapiens P27105
Y2H Array
32296183
Intra GIMAP5 Q96F15 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 MS4A14 Homo sapiens Q96JA4
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 MS4A14 Homo sapiens Q96JA4
Validated Y2H
32296183
Intra GIMAP5 Q96F15 MS4A14 Homo sapiens Q96JA4
Y2H Array
32296183
Intra GIMAP5 Q96F15 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra GIMAP5 Q96F15 TM4SF18 Homo sapiens Q96CE8
Y2H Array
32296183
Intra GIMAP5 Q96F15 TM4SF18 Homo sapiens Q96CE8
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 SCN3B Homo sapiens Q9NY72
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 SCN3B Homo sapiens Q9NY72
Y2H Array
32296183
Intra GIMAP5 Q96F15 SCN3B Homo sapiens Q9NY72
Validated Y2H
32296183
Intra GIMAP5 Q96F15 KIR3DL3 Homo sapiens Q8N743
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 KIR3DL3 Homo sapiens Q8N743
Y2H Array
32296183
Intra GIMAP5 Q96F15 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 SLC35C2 Homo sapiens Q9NQQ7-3
Validated Y2H
32296183
Intra GIMAP5 Q96F15 SLC35C2 Homo sapiens Q9NQQ7-3
Y2H Array
32296183
Intra GIMAP5 Q96F15 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra GIMAP5 Q96F15 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 SPACA1 Homo sapiens Q9HBV2
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 SPACA1 Homo sapiens Q9HBV2
Validated Y2H
32296183
Intra GIMAP5 Q96F15 SPACA1 Homo sapiens Q9HBV2
Y2H Array
32296183
Intra GIMAP5 Q96F15 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra GIMAP5 Q96F15 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 TSPAN18 Homo sapiens Q8WUV1
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 TSPAN18 Homo sapiens Q8WUV1
Y2H Array
32296183
Intra GIMAP5 Q96F15 BTNL9 Homo sapiens Q6UXG8-3
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 BTNL9 Homo sapiens Q6UXG8-3
Y2H Array
32296183
Intra GIMAP5 Q96F15 ADGRG3 Homo sapiens Q86Y34
Y2H Array
32296183
Intra GIMAP5 Q96F15 ADGRG3 Homo sapiens Q86Y34
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 DKK4 Homo sapiens Q9UBT3
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 DKK4 Homo sapiens Q9UBT3
Validated Y2H
32296183
Intra GIMAP5 Q96F15 DKK4 Homo sapiens Q9UBT3
Y2H Array
32296183
Intra GIMAP5 Q96F15 SHISAL1 Homo sapiens Q3SXP7
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 SHISAL1 Homo sapiens Q3SXP7
Y2H Array
32296183
Intra GIMAP5 Q96F15 MILR1 Homo sapiens Q7Z6M3
Y2H Array
32296183
Intra GIMAP5 Q96F15 MILR1 Homo sapiens Q7Z6M3
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 RNASEK Homo sapiens Q6P5S7
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 RNASEK Homo sapiens Q6P5S7
Y2H Array
32296183
Intra GIMAP5 Q96F15 ELOVL4 Homo sapiens Q9GZR5
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 ELOVL4 Homo sapiens Q9GZR5
Validated Y2H
32296183
Intra GIMAP5 Q96F15 ELOVL4 Homo sapiens Q9GZR5
Y2H Array
32296183
Intra GIMAP5 Q96F15 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra GIMAP5 Q96F15 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra GIMAP5 Q96F15 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra GIMAP5 Q96F15 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 LAYN Homo sapiens Q6UX15-2
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 LAYN Homo sapiens Q6UX15-2
Y2H Array
32296183
Intra GIMAP5 Q96F15 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
Intra GIMAP5 Q96F15 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 AQP3 Homo sapiens Q92482
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 AQP3 Homo sapiens Q92482
Y2H Array
32296183
Intra GIMAP5 Q96F15 GRAMD2B Homo sapiens Q96HH9
Validated Y2H
25416956
Intra GIMAP5 Q96F15 GRAMD2B Homo sapiens Q96HH9
Y2H Prey Pooling
25416956
Intra GIMAP5 Q96F15 M6PR Homo sapiens P20645
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 M6PR Homo sapiens P20645
Y2H Array
32296183
Intra GIMAP5 Q96F15 ZFYVE27 Homo sapiens Q5T4F4
Y2H Array
32296183
Intra GIMAP5 Q96F15 ZFYVE27 Homo sapiens Q5T4F4
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 IFNGR2 Homo sapiens P38484
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 IFNGR2 Homo sapiens P38484
Y2H Array
32296183
Intra GIMAP5 Q96F15 CD33 Homo sapiens P20138
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 CD33 Homo sapiens P20138
Y2H Array
32296183
Intra GIMAP5 Q96F15 GJB3 Homo sapiens O75712
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 GJB3 Homo sapiens O75712
Y2H Array
32296183
Intra GIMAP5 Q96F15 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra GIMAP5 Q96F15 GORAB Homo sapiens Q5T7V8
Y2H Array
32296183
Intra GIMAP5 Q96F15 GORAB Homo sapiens Q5T7V8
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 SLC10A1 Homo sapiens Q14973
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 SLC10A1 Homo sapiens Q14973
Y2H Array
32296183
Intra GIMAP5 Q96F15 EMP1 Homo sapiens P54849
Y2H Array
32296183
Intra GIMAP5 Q96F15 EMP1 Homo sapiens P54849
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 SYT1 Homo sapiens P21579
Y2H Array
32296183
Intra GIMAP5 Q96F15 SYT1 Homo sapiens P21579
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 EDA2R Homo sapiens Q9HAV5
Validated Y2H
32296183
Intra GIMAP5 Q96F15 EDA2R Homo sapiens Q9HAV5
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 EDA2R Homo sapiens Q9HAV5
Y2H Array
32296183
Intra GIMAP5 Q96F15 EDA Homo sapiens Q92838
Y2H Prey Pooling
25416956
Intra GIMAP5 Q96F15 EDA Homo sapiens Q92838
Validated Y2H
25416956
Intra GIMAP5 Q96F15 EDA Homo sapiens Q92838
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 EDA Homo sapiens Q92838
Y2H Array
32296183
Intra GIMAP5 Q96F15 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra GIMAP5 Q96F15 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra GIMAP5 Q96F15 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 TM4SF19 Homo sapiens Q96DZ7
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 TM4SF19 Homo sapiens Q96DZ7
Y2H Array
32296183
Intra GIMAP5 Q96F15 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra GIMAP5 Q96F15 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra GIMAP5 Q96F15 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 STX1A Homo sapiens Q16623
Y2H Array
32296183
Intra GIMAP5 Q96F15 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra GIMAP5 Q96F15 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 MGST3 Homo sapiens O14880
Y2H Array
32296183
Intra GIMAP5 Q96F15 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra GIMAP5 Q96F15 SMIM3 Homo sapiens Q9BZL3
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 SMIM3 Homo sapiens Q9BZL3
Validated Y2H
32296183
Intra GIMAP5 Q96F15 SMIM3 Homo sapiens Q9BZL3
Y2H Array
32296183
Intra GIMAP5 Q96F15 FATE1 Homo sapiens Q969F0
Y2H Array
32296183
Intra GIMAP5 Q96F15 FATE1 Homo sapiens Q969F0
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra GIMAP5 Q96F15 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra GIMAP5 Q96F15 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra GIMAP5 Q96F15 CYBRD1 Homo sapiens Q53TN4
Y2H Array
32296183
Intra GIMAP5 Q96F15 CYBRD1 Homo sapiens Q53TN4
Y2H Prey Pooling
32296183
Intra GIMAP5 Q96F15 CYB561 Homo sapiens P49447
Y2H Array
32296183
Intra GIMAP5 Q96F15 CYB561 Homo sapiens P49447
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Portal Hypertension, Noncirrhotic, 2

NCPH2

Portal Hypertension, Non-Cirrhotic, 2
Portal Hypertension

Hypertension, Portal

Hypertension Portal

Pht - [Portal Hypertension]

Portal Htn
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]
Lymphopenia

Lymphocytopenia
Type 1 Diabetes Mellitus 8

Diabetes Mellitus, Insulin-Dependent, 8

Iddm8

Insulin-Dependent Diabetes Mellitus 8

T1D8

Insulin-Dependent Diabetes Mellitus-8
Wolfram Syndrome 2

WFS2
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Pancytopenia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05425 GIMAP5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GIMAP5 RGD RGD:628871
Mus musculus GIMAP5 MGD MGI:2442232