HHATL - hedgehog acyltransferase like Gene

Homo sapiens

Also known as GUP1; OACT3; C3orf3; MBOAT3; MSTP002

Gene ID: 57467 | Gene type: protein coding

About HHATL

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:42,692,663-42,702,798 (from NCBI)

This gene has 12 transcripts (splice variants), 248 orthologues and 1 paralogue. Restricted expression toward heart (RPKM 165.4).

Summary

Predicted to enable Acyltransferase activity. Predicted to be involved in negative regulation of N-terminal protein palmitoylation. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

HHATL Products(1)

mRNA	Protein	Name
NM_020707.4	NP_065758.3	protein-cysteine N-palmitoyltransferase HHAT-like protein

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11374908	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HHATL Protein Structure

MBOAT

0
100
200
300
400
504 a.a.

Protein Preferred Names

Protein Names

protein-cysteine N-palmitoyltransferase HHAT-like protein

GUP1 glycerol uptake/transporter homolog

HHATL Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HHATL	Q9HCP6	CISD2	Homo sapiens	Q8N5K1	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	CISD2	Homo sapiens	Q8N5K1	Y2H Array	32296183
Intra	HHATL	Q9HCP6	GPX8	Homo sapiens	Q8TED1	Y2H Array	32296183
Intra	HHATL	Q9HCP6	GPX8	Homo sapiens	Q8TED1	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	FNDC9	Homo sapiens	Q8TBE3	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	FNDC9	Homo sapiens	Q8TBE3	Y2H Array	32296183
Intra	HHATL	Q9HCP6	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	HHATL	Q9HCP6	MUC1	Homo sapiens	P15941-11	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	MUC1	Homo sapiens	P15941-11	Y2H Array	32296183
Intra	HHATL	Q9HCP6	CPLX4	Homo sapiens	Q7Z7G2	Y2H Array	32296183
Intra	HHATL	Q9HCP6	CPLX4	Homo sapiens	Q7Z7G2	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	SUSD3	Homo sapiens	Q96L08	Y2H Array	32296183
Intra	HHATL	Q9HCP6	SUSD3	Homo sapiens	Q96L08	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	HHATL	Q9HCP6	MILR1	Homo sapiens	Q7Z6M3	Y2H Array	32296183
Intra	HHATL	Q9HCP6	MILR1	Homo sapiens	Q7Z6M3	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	AMIGO1	Homo sapiens	Q86WK6	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	AMIGO1	Homo sapiens	Q86WK6	Y2H Array	32296183
Intra	HHATL	Q9HCP6	FKBP7	Homo sapiens	Q9Y680	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	FKBP7	Homo sapiens	Q9Y680	Validated Y2H	32296183
Intra	HHATL	Q9HCP6	FKBP7	Homo sapiens	Q9Y680	Y2H Array	32296183
Intra	HHATL	Q9HCP6	PVR	Homo sapiens	P15151	Y2H Array	32296183
Intra	HHATL	Q9HCP6	PVR	Homo sapiens	P15151	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	TMX2	Homo sapiens	Q9Y320	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	TMX2	Homo sapiens	Q9Y320	Validated Y2H	32296183
Intra	HHATL	Q9HCP6	TMX2	Homo sapiens	Q9Y320	Y2H Array	32296183
Intra	HHATL	Q9HCP6	ERGIC3	Homo sapiens	Q9Y282	Y2H Prey Pooling	32296183
Intra	HHATL	Q9HCP6	ERGIC3	Homo sapiens	Q9Y282	Validated Y2H	32296183
Intra	HHATL	Q9HCP6	ERGIC3	Homo sapiens	Q9Y282	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Nemaline Myopathy 8

NEM8	Nemaline Myopathy 8, Autosomal Recessive
Myopathy, Nemaline, Type 8

Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9	Left Ventricular Noncompaction 5
Dilated Cardiomyopathy 1e	Dilated Cardiomyopathy 1s
CMD1E	Cdcd2
Cardiomyopathy, Dilated, 1y	CMD1Y
Cardiomyopathy, Dilated, 1s	CMD1S
Dilated Cardiomyopathy 1y	Dilated Cardiomyopathy With Conduction Defect 2
Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia	Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia
Cardiomyopathy, Dilated, With Conduction Defect 2	Cardiomyopathy Dilated With Conduction Defect Type 2
Cardiomyopathy, Dilated 1e	Cardiomyopathy, Dilated 1s
Cardiomyopathy, Dilated 1y	Left Ventricular Non-Compaction 5
LVNC5	Left Ventricular Non-Compaction 9
LVNC9	Cardiomyopathy, Dilated, Type 1e
Cardiomyopathy, Dilated, Type 1s	Cardiomyopathy, Dilated, Type 1y

Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 2	PKD2
Polycystic Kidney Disease, Adult, Type Ii	Apkd2
Polycystic Kidney Disease, Type 2	Adpkd2
Adult Polycystic Kidney Disease Type 2	Autosomal Dominant Polycystic Kidney Disease 2
Pkd-2	Polycystic Kidney Disease Adult Type Ii
Polycystic Kidney Type 2 Autosomal Dominant Disease	Kidney Disease, Polycystic, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06158	HHATL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	HHATL	VGNC	VGNC:29838
Macaca mulatta	HHATL	VGNC	VGNC:73161
Canis familiaris	HHATL	VGNC	VGNC:49672
Felis catus	HHATL	VGNC	VGNC:62808
Rattus norvegicus	HHATL	RGD	RGD:1311911
Mus musculus	HHATL	MGD	MGI:1922020

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