2. Gene
  3. GRK5 - G protein-coupled receptor kinase 5 Gene

GRK5 - G protein-coupled receptor kinase 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GPRK5; FP2025

Gene ID: 2869 | Gene type: protein coding

About GRK5

Cytogenetic location: 10q26.11 Genomic coordinates (GRCh38): 10:119,207,571-119,459,745 (from NCBI)

This gene has 2 transcripts (splice variants), 141 orthologues and 7 paralogues. Ubiquitous expression in lung (RPKM 30.9), spleen (RPKM 17.1) and 23 other tissues.

Summary

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating their deactivation. It has also been shown to play a role in regulating the motility of polymorphonuclear leukocytes (PMNs). [provided by RefSeq, Jul 2008]

GRK5 Products(1)

mRNA Protein Name
NM_005308.3 NP_005299.1 G protein-coupled receptor kinase 5
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables beta-adrenergic receptor kinase activity IMP
IMP: Inferred from mutant phenotype
20038610 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
17986524 GOA
enables protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
20124405 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
20124405 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
22099983 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
14976207 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
22099983 GOA
involved in tachykinin receptor signaling pathway IDA
IDA: Inferred from direct assay
17986524 GOA
Cellular Component GO Annotation Evidence Reference Source
located in plasma membrane IDA
IDA: Inferred from direct assay
14976207 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GRK5 Protein Structure

RGS

RGS: Regulator of G protein signaling domain (54 - 170)

Pkinase

Pkinase: Protein kinase domain (187 - 448)

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  • 500
  • 590 a.a.
Protein Preferred Names Protein Names

G protein-coupled receptor kinase 5

g protein-coupled receptor kinase GRK5

Related Agents

Pre-clinical Phase
Bioactive Molecules (19)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-103045 CMPD101 Inhibitor 98.95% Unkown
HY-136561 GRK5-IN-2 99.92% Unkown
HY-109562A CCG258208 hydrochloride 98.05% Unkown
HY-18991 CCG215022 Inhibitor 98.69% Unkown
HY-47573 CCG273441 Inhibitor 98.67% Unkown
HY-143248 KR-39038 Inhibitor 99.48% Unkown
HY-139690 CCG258747 Inhibitor 98.96% Unkown
HY-149720 GRL018-21 Inhibitor 96.91% Unkown
HY-108601A (S)-Ro 32-0432 Inhibitor / Unkown
HY-109562 CCG258208 / Unkown
HY-108601 (S)-Ro 32-0432 free base Inhibitor / Unkown
HY-118046 GSK2163632A Inhibitor / Unkown
HY-119232 GSK466317A Inhibitor / Unkown
HY-150021 GRK5-IN-3 Inhibitor / Unkown
HY-150022 GRK5-IN-4 Inhibitor / Unkown
HY-150039 CCG-271423 Inhibitor / Unkown
HY-150040 CCG-273463 Inhibitor / Unkown
HY-RS05816 GRK5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-159996 GRL093-22 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GRK5 MGD MGI:109161
Felis catus GRK5 VGNC VGNC:97451
Rattus norvegicus GRK5 RGD RGD:61985
Canis familiaris GRK5 VGNC VGNC:41505
Bos taurus GRK5 VGNC VGNC:29656
Macaca mulatta GRK5 VGNC VGNC:73267
Others GRK5 NCBI