MACROD1 - mono-ADP ribosylhydrolase 1 Gene

Homo sapiens

Also known as LRP16

Gene ID: 28992 | Gene type: protein coding

About MACROD1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:63,998,558-64,166,113 (from NCBI)

This gene has 8 transcripts (splice variants), 170 orthologues and 2 paralogues. Broad expression in kidney (RPKM 9.5), prostate (RPKM 2.7) and 22 other tissues.

Summary

Enables ADP-ribosylglutamate hydrolase activity and deacetylase activity. Involved in cellular response to DNA damage stimulus; peptidyl-glutamate ADP-deribosylation; and purine nucleoside metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MACROD1 Products(2)

mRNA	Protein	Name
NM_001411019.1	NP_001397948.1	ADP-ribose glycohydrolase MACROD1 isoform 2
NM_014067.4	NP_054786.2	ADP-ribose glycohydrolase MACROD1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP-ribosylglutamate hydrolase activity	IDA IDA: Inferred from direct assay	23474714	GOA
enables deacetylase activity	IDA IDA: Inferred from direct assay	21257746	GOA
enables hydrolase activity, acting on glycosyl bonds	IDA IDA: Inferred from direct assay	23474712	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17914104	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA damage response	IMP IMP: Inferred from mutant phenotype	23474712	GOA
involved in peptidyl-glutamate ADP-deribosylation	IDA IDA: Inferred from direct assay	23474714	GOA
involved in protein de-ADP-ribosylation	IDA IDA: Inferred from direct assay	23474712	GOA
involved in purine nucleoside metabolic process	IDA IDA: Inferred from direct assay	21257746	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	23474712	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MACROD1 Protein Structure

Macro

0
100
200
300
325 a.a.

Protein Preferred Names

Protein Names

ADP-ribose glycohydrolase MACROD1

MACRO domain containing 1

MACROD1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MACROD1	Q9BQ69	KRT18	Homo sapiens	P05783	Anti Bait CoIP	20035625
Intra	MACROD1	Q9BQ69	KRT18	Homo sapiens	P05783	Y2H	20035625
Intra	MACROD1	Q9BQ69	KRT18	Homo sapiens	P05783	Pull Down	20035625
Intra	MACROD1	Q9BQ69	PARP1	Homo sapiens	P09874	Anti Tag CoIP	33961781
Intra	MACROD1	Q9BQ69	PARP1	Homo sapiens	P09874	Anti Tag CoIP	28514442
Intra	MACROD1	Q9BQ69	KPNA1	Homo sapiens	P52294	Y2H Prey Pooling	32296183
Intra	MACROD1	Q9BQ69	KPNA1	Homo sapiens	P52294	Y2H Array	32296183
Intra	MACROD1	Q9BQ69	RELA	Homo sapiens	Q04206	Pull Down	21483817
Intra	MACROD1	Q9BQ69	ESR1	Homo sapiens	P03372	Anti Bait CoIP	17914104
Intra	MACROD1	Q9BQ69	ESR1	Homo sapiens	P03372	Pull Down	17914104
Intra	MACROD1	Q9BQ69	ESR1	Homo sapiens	P03372	Anti Bait CoIP	20035625

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Cardiomyopathy, Dilated, 1e

Left Ventricular Noncompaction 9	Left Ventricular Noncompaction 5
Dilated Cardiomyopathy 1e	Dilated Cardiomyopathy 1s
CMD1E	Cdcd2
Cardiomyopathy, Dilated, 1y	CMD1Y
Cardiomyopathy, Dilated, 1s	CMD1S
Dilated Cardiomyopathy 1y	Dilated Cardiomyopathy With Conduction Defect 2
Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia	Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia
Cardiomyopathy, Dilated, With Conduction Defect 2	Cardiomyopathy Dilated With Conduction Defect Type 2
Cardiomyopathy, Dilated 1e	Cardiomyopathy, Dilated 1s
Cardiomyopathy, Dilated 1y	Left Ventricular Non-Compaction 5
LVNC5	Left Ventricular Non-Compaction 9
LVNC9	Cardiomyopathy, Dilated, Type 1e
Cardiomyopathy, Dilated, Type 1s	Cardiomyopathy, Dilated, Type 1y

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07945	MACROD1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MACROD1	VGNC	VGNC:107456
Bos taurus	MACROD1	VGNC	VGNC:56272
Mus musculus	MACROD1	MGD	MGI:2147583
Felis catus	MACROD1	VGNC	VGNC:103132
Canis familiaris	MACROD1	VGNC	VGNC:51880
Rattus norvegicus	MACROD1	RGD	RGD:628701

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